Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(109 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(223 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(83 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(74 prodotti)
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Trovati 3730 prodotti di "Ciclo cellulare/Checkpoint"
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Ribavirin
CAS:Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.Formula:C8H12N4O5Purezza:99.09% - 99.83%Colore e forma:Less Solid Colourless SolidPeso molecolare:244.20Pefloxacin Mesylate Dihydrate
CAS:<p>Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).</p>Formula:C17H20FN3O3·CH4O3S·2H2OPurezza:99.79%Colore e forma:SolidPeso molecolare:465.49SU056
CAS:<p>SU056 is a YB-1 inhibitor that induces cell-cycle arrest, apoptosis, and inhibits ovarian cancer cell migration.</p>Formula:C20H16FNO5Purezza:99.89%Colore e forma:SoildPeso molecolare:369.34Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:426.41Ribonuclease T1
CAS:<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Colore e forma:Solid5'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Formula:C46H56N7O9PColore e forma:SolidPeso molecolare:881.95Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Colore e forma:Odour SolidFRα-targeting peptide C7 TFA
<p>FRα-targeting peptide C7 TFA is a selective peptide ligand for the folate receptor alpha (FRα) that specifically binds to FRα-expressing cells and has tumor-targeting capabilities in vivo. It is applicable in research related to tumor diagnosis and therapy.</p>Colore e forma:Odour Solidm7GpppUmpG
CAS:m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formula:C31H42N12O26P4Colore e forma:SolidPeso molecolare:1122.63IBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Formula:C43H54N5O8PColore e forma:SolidPeso molecolare:799.9065-Methylcytidine 5′-triphosphate
CAS:5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormula:C10H18N3O14P3Colore e forma:SolidPeso molecolare:497.18DSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Colore e forma:Odour SolidAnti-c-myc Antibody (9E10)
<p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>Colore e forma:Odour LiquidClofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Formula:C10H10ClFN5Na3O9P2Colore e forma:SolidPeso molecolare:529.58Ceftriaxone
CAS:<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>Formula:C18H18N8O7S3Purezza:96.08%Colore e forma:SolidPeso molecolare:554.58Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formula:C35H39N9O3Colore e forma:SolidPeso molecolare:633.74α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formula:C5H9NO4Purezza:99.91%Colore e forma:SolidPeso molecolare:147.13IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formula:C16H20O6Colore e forma:SolidPeso molecolare:308.12599Py-MAA-Val-Cit-PAB-DX8951
CAS:Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formula:C57H66FN11O13SColore e forma:SolidPeso molecolare:1164.26XY028-133
CAS:<p>XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.</p>Formula:C53H67N11O7SPurezza:97.11%Colore e forma:SolidPeso molecolare:1002.23WRN inhibitor 17
CAS:<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Formula:C33H34F4N4O6SColore e forma:SolidPeso molecolare:690.71Endo-1,4-β-xylanase
CAS:Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Colore e forma:SolidPROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formula:C44H38N6O8Colore e forma:SolidPeso molecolare:778.27511Clofarabine-5'-triphosphate
CAS:Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.Formula:C10H14ClFN5O12P3Colore e forma:SolidPeso molecolare:543.62Guanosine 5'-triphosphate trisodium salt hydrate
CAS:5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formula:C10H18N5NaO15P3Purezza:98%Colore e forma:SolidPeso molecolare:564.185Xanthosine-5'-Triphosphate
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Formula:C10H15N4O15P3Colore e forma:SolidPeso molecolare:524.164CDK7-IN-7
CAS:<p>CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).</p>Formula:C20H20BrF3N6O2Colore e forma:SolidPeso molecolare:513.319MYC-IN-2
CAS:MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formula:C25H17N3O2SColore e forma:SolidPeso molecolare:423.49Phen-DC3 Trifluoromethanesulfonate
CAS:<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>Formula:C36H26F6N6O8S2Purezza:98%Colore e forma:SolidPeso molecolare:848.75Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Colore e forma:SolidPeso molecolare:463.64Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1Erythromycin lactobionate
CAS:<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>Formula:C49H89NO25Colore e forma:SolidPeso molecolare:1092.2335-Aza-xylo-cytidine
<p>5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formula:C8H12N4O5Colore e forma:SolidPeso molecolare:244.2TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36CTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Formula:C20H22F3N7O3S2Purezza:99.97%Colore e forma:SolidPeso molecolare:529.56DNA Gyrase-IN-12
<p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>Colore e forma:Odour SolidSMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38Carboxy-pyridostatin
CAS:<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>Formula:C35H34N10O7Colore e forma:SolidPeso molecolare:706.71N6-Methyl-2'-O-(2-methoxyethyl) adenosine
N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formula:C14H21N5O5Colore e forma:SolidPeso molecolare:339.35RNA polymerase II-IN-2
RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.Formula:C41H58N10O12SColore e forma:SolidPeso molecolare:915.02Nogalamycin
CAS:Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.Formula:C39H49NO16Purezza:98%Colore e forma:SolidPeso molecolare:787.812JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.445'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.Formula:C38H47N3O8SiColore e forma:SolidPeso molecolare:701.892wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Colore e forma:Odour SolidDihydro-5-azacytidine
CAS:Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Formula:C8H14N4O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:246.22Biotin-PEG8-Vidarabine
Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.Formula:C36H60N8O13SColore e forma:SolidPeso molecolare:844.97Rachelmycin
CAS:Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.Formula:C37H33N7O8Colore e forma:SolidPeso molecolare:703.712DSPE-PEG1000-cRGD
DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.Colore e forma:Odour SolidEtrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Colore e forma:LiquidCDK9-IN-25
<p>CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.</p>Formula:C15H16FN5Purezza:98%Colore e forma:SolidPeso molecolare:285.32HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formula:C24H27FN4O5Colore e forma:SolidPeso molecolare:470.49DSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Colore e forma:Odour SolidUridine triphosphate 13C9,15N2 sodium
CAS:Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.Formula:C9H1415N2NaO15P3Colore e forma:SolidPeso molecolare:517.04Erythromycin A dihydrate
CAS:Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.Formula:C37H69NO14Colore e forma:SolidPeso molecolare:751.94Fibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Formula:C38H64N8O15Purezza:98%Colore e forma:SolidPeso molecolare:872.96Carbazole
CAS:<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>Formula:C12H9NPurezza:99.82%Colore e forma:SolidPeso molecolare:167.211Cytidine 5'-diphosphate trisodium salt
CAS:<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formula:C9H15N3Na3O11P2Purezza:99.55%Colore e forma:White Crystalline PowderPeso molecolare:472.15ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Formula:C32H30N5Na3O10Colore e forma:SolidPeso molecolare:713.5813-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Formula:C12H19F2N6O12P3Colore e forma:SolidPeso molecolare:570.23DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Colore e forma:Odour Solid5-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Formula:C27H30N2O9Colore e forma:SolidPeso molecolare:526.54PD-1/PD-L1-IN-51
<p>PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.</p>Colore e forma:Odour Solid5'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Formula:C44H49F2N4O7PColore e forma:SolidPeso molecolare:814.85N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formula:C21H35N12O17P3Colore e forma:SolidPeso molecolare:820.49Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:SolidPeso molecolare:587.54TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formula:C14H19N5O8Colore e forma:SolidPeso molecolare:385.33Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formula:C25H41N11O8SColore e forma:SolidPeso molecolare:655.727N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formula:C14H22N2O7Colore e forma:SolidPeso molecolare:330.33Isocytosine
CAS:Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C4H5N3OColore e forma:White To Off-White SolidPeso molecolare:111.1Remdesivir nucleoside monophosphate
CAS:Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.Formula:C12H14N5O7PColore e forma:SolidPeso molecolare:371.24EFdA-TP
CAS:<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>Formula:C12H15FN5O12P3Colore e forma:SolidPeso molecolare:533.195STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purezza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:Odour Liquid5'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C16H27N5O3SiColore e forma:SolidPeso molecolare:365.509Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.308CDK7-IN-5
CAS:CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).Formula:C34H45N9O2Colore e forma:SolidPeso molecolare:611.795Gly-Arg-Gly-Asp-Ser
CAS:<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formula:C17H30N8O9Purezza:98%Colore e forma:SolidPeso molecolare:490.47c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Formula:C35H30N6O5Colore e forma:SoildPeso molecolare:614.65PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Colore e forma:Odour SolidJB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColore e forma:SolidPeso molecolare:3161.32Antibacterial agent 144
Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.Formula:C26H23N7O3Colore e forma:SolidPeso molecolare:481.51(S)-DI-87
CAS:<p>(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.</p>Formula:C23H30N6O3S2Purezza:99.42%Colore e forma:SoildPeso molecolare:502.65PROTAC CDK9 degrader-2
CAS:PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.Formula:C39H36N6O10Purezza:98%Colore e forma:SolidPeso molecolare:748.74Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Formula:C42H50N7O7PColore e forma:SolidPeso molecolare:795.878Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Formula:C59H80N4O22S4Colore e forma:SolidPeso molecolare:1325.54Mumefural
CAS:<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formula:C12H12O9Colore e forma:SolidPeso molecolare:300.22Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formula:C184H284N52O57S8Purezza:98%Colore e forma:SolidPeso molecolare:4393.07Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formula:C21H25FN4O2Colore e forma:SolidPeso molecolare:384.45Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Formula:C27H23ClF2N4O2Colore e forma:SolidPeso molecolare:508.9475'-O-DMT-ibu-dC
CAS:5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formula:C34H37N3O7Colore e forma:SolidPeso molecolare:599.67WAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Formula:C11H14N4O3Purezza:99.53%Colore e forma:SolidPeso molecolare:250.25Cytarabine triphosphate
CAS:Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formula:C9H16N3O14P3Colore e forma:SolidPeso molecolare:483.16Gantofiban
CAS:Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formula:C21H29N5O6Purezza:99.57%Colore e forma:SolidPeso molecolare:447.48Nusinersen
CAS:<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Purezza:98.62%Colore e forma:SolidChrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Formula:C28H28O9Colore e forma:SolidPeso molecolare:508.52(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formula:C25H34O10Colore e forma:SolidPeso molecolare:494.5372'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.Formula:C10H14N5Na2O8PColore e forma:SolidPeso molecolare:409.2025'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Formula:C10H13FN2O6Colore e forma:SolidPeso molecolare:276.22SNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formula:C15H14N2OPurezza:99.96%Colore e forma:SolidPeso molecolare:238.28PLK1-IN-2
CAS:PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.Formula:C24H27FN8OSColore e forma:SolidPeso molecolare:494.59
