Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formula:C14H19Cl2N3O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:364.29Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Purezza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Colore e forma:LiquidPeso molecolare:N/A2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Formula:C6H6N4OPurezza:99.21% - 99.42%Colore e forma:SolidPeso molecolare:150.14JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formula:C15H12F2N6O3SPurezza:99.1% - 99.85%Colore e forma:SolidPeso molecolare:394.36Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formula:C26H30N6O3Purezza:97.88% - 98.79%Colore e forma:White PowderPeso molecolare:474.55TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formula:C21H20N2O3SPurezza:99.54%Colore e forma:SolidPeso molecolare:380.465'-Deoxy-5-fluorocytidine
CAS:5'-Deoxy-5-fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine.Formula:C9H12FN3O4Purezza:99.67%Colore e forma:White SolidPeso molecolare:245.21IMT1B
CAS:<p>IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.</p>Formula:C24H21ClFNO6Purezza:98.26% - 99.83%Colore e forma:SolidPeso molecolare:473.88Ibezapolstat
CAS:Ibezapolstat (ACX-362E) is an antibiotic with antibacterial activity that inhibits Clostridium difficile.Formula:C18H20Cl2N6O2Purezza:98% - 99.429%Colore e forma:SolidPeso molecolare:423.3Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purezza:97.9% - 99.47%Colore e forma:SolidPeso molecolare:387.86CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formula:C22H23Cl2N7Purezza:96.2% - 99.81%Colore e forma:SolidPeso molecolare:456.37S-trityl-L-Cysteine
CAS:S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5Formula:C22H21NO2SPurezza:97.02%Colore e forma:Almost White To Light Yellow Granular PowderPeso molecolare:363.47TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purezza:98.98%Colore e forma:SolidPeso molecolare:474.33Myoseverin
CAS:<p>Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.</p>Formula:C24H28N6O2Purezza:99.25%Colore e forma:SolidPeso molecolare:432.52BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formula:C17H12Cl2F2N4OSPurezza:99.31% - 99.81%Colore e forma:SolidPeso molecolare:429.27N6,N6-Dimethyladenosine
CAS:<p>N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.</p>Formula:C12H17N5O4Purezza:98.79%Colore e forma:White PowderPeso molecolare:295.29Antitumor agent-152
CAS:<p>Organic compound, potential dCK inhibitor, with 2-ethyl-3-methoxyphenyl-1,3-thiazole and pyrimidine units.</p>Formula:C17H19N5O2S2Purezza:95.00%Colore e forma:SolidPeso molecolare:389.5Dasabuvir sodium
CAS:Dasabuvir sodium (ABT-333) inhibits HCV NS5B polymerase, targeting genotypes 1a (EC50: 7.7 nM) and 1b (EC50: 1.8 nM).Formula:C26H26N3NaO5SColore e forma:SolidPeso molecolare:515.56Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purezza:98.31% - >99.99%Colore e forma:SolidPeso molecolare:518.92Ara-G
CAS:<p>Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.</p>Formula:C10H13N5O5Purezza:98.74%Colore e forma:Slightly Off White To White PowderPeso molecolare:283.24BRD32048
CAS:<p>BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.</p>Formula:C16H22N6OPurezza:99.87%Colore e forma:SolidPeso molecolare:314.39Proguanil
CAS:Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .Formula:C11H16ClN5Purezza:99.6%Colore e forma:SolidPeso molecolare:253.73Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Formula:C27H26N6OPurezza:99.67%Colore e forma:SolidPeso molecolare:450.53IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Formula:C24H28N4O4Purezza:99.8% - 99.85%Colore e forma:SolidPeso molecolare:436.5LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Formula:C18H22Cl2N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:401.35Clevudine
CAS:<p>Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.</p>Formula:C10H13FN2O5Purezza:99.88% - 99.97%Colore e forma:SolidPeso molecolare:260.22A-286982
CAS:<p>A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.</p>Formula:C24H27N3O4SPurezza:97.81%Colore e forma:SolidPeso molecolare:453.55STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Formula:C15H11NO3S2Purezza:98.09% - 99.45%Colore e forma:SolidPeso molecolare:317.38PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purezza:97.58% - 99.94%Colore e forma:SolidPeso molecolare:419.48CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purezza:97.52% - 99.52%Colore e forma:SolidPeso molecolare:500.33Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Formula:C28H43N9O7Purezza:>99.99%Colore e forma:SolidPeso molecolare:617.7E7820
CAS:<p>E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).</p>Formula:C17H12N4O2SPurezza:98.31% - 99.11%Colore e forma:SolidPeso molecolare:336.37ML216
CAS:ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).Formula:C15H9F4N5OSPurezza:98.12%Colore e forma:SolidPeso molecolare:383.326-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Formula:C8H7BrO3Purezza:99.82%Colore e forma:SolidPeso molecolare:231.04Tirapazamine
CAS:Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.Formula:C7H6N4O2Purezza:96.65% - 99.87%Colore e forma:Orange-Red Crystalline PowderPeso molecolare:178.15EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Formula:C25H24N2O4Purezza:98.51%Colore e forma:SolidPeso molecolare:416.47TH588 hydrochloride
CAS:TH588 hydrochloride is first-in-class inhibitor of nudix hydrolase family that selectively and effectively bind and inhibit the MTH1 with IC50 value of 5 nM.Formula:C13H13Cl3N4Colore e forma:SolidPeso molecolare:331.63TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Formula:C16H14Cl2N2O4SPurezza:97.01%Colore e forma:SolidPeso molecolare:401.26GAK inhibitor 49 hydrochloride
Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.Formula:C20H23ClN2O5Colore e forma:SolidPeso molecolare:406.86HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurezza:99.44%Colore e forma:Pale Yellow Crystalline SolidPeso molecolare:277.34LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formula:C29H48N12O12S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:820.89Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formula:C29H26FN5O4SPurezza:97.45% - 99.4%Colore e forma:SolidPeso molecolare:559.61AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurezza:>99.99%Colore e forma:SolidPeso molecolare:405.24NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Formula:C16H19ClN6OPurezza:98% - 99.34%Colore e forma:SolidPeso molecolare:346.81Zoliflodacin
CAS:Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor.Formula:C22H22FN5O7Purezza:99.82% - 99.93%Colore e forma:SolidPeso molecolare:487.44BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Formula:C16H14N2Purezza:97.81%Colore e forma:SolidPeso molecolare:234.3PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Formula:C14H11F3N2O2Purezza:99.87%Colore e forma:SolidPeso molecolare:296.24MK-8745
CAS:<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Formula:C20H19ClFN5OSPurezza:99.09% - 99.79%Colore e forma:SolidPeso molecolare:431.91GS-441524 HCl
CAS:GS-441524: Inhibits FIP virus, EC50 at 0.78 μM, precursor to active triphosphate, non-toxic up to 100 μM, works at ≥1 μM, metabolite of Remdesivir.Formula:C12H14ClN5O4Colore e forma:SolidPeso molecolare:327.72ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purezza:99.39%Colore e forma:SolidPeso molecolare:334.32
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