Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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Aplidine
CAS:Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).Formula:C57H87N7O15Purezza:99.86%Colore e forma:SolidPeso molecolare:1110.34POL1-IN-1
CAS:<p>POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂，IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。</p>Formula:C21H20N6Purezza:98% - 98.01%Colore e forma:SolidPeso molecolare:356.42RCM-1
CAS:RCM-1 is an inhibitor of FOXM1.Formula:C20H12N2OS4Purezza:98.08%Colore e forma:SolidPeso molecolare:424.58Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C31H43F6N9O12Purezza:95.28% - ≥95%Colore e forma:SolidPeso molecolare:847.72MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:486.56Poloxin
CAS:<p>Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).</p>Formula:C18H19NO3Purezza:99.19%Colore e forma:SolidPeso molecolare:297.35C/EBPα inducer 1
CAS:<p>C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) is a potential inducer of myeloid differentiation via</p>Formula:C20H12FN3O4Purezza:98.99%Colore e forma:SolidPeso molecolare:377.336-Mercaptopurine hydrate
CAS:6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Formula:C5H6N4OSPurezza:97.54% - 99.14%Colore e forma:Light Yellow Crystalline PowderPeso molecolare:170.19Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurezza:98.91%Colore e forma:SolidPeso molecolare:413.4Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Formula:C19H22N8OPurezza:98.1%Colore e forma:SolidPeso molecolare:378.43VPC-80051 racemate
CAS:VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.Formula:C16H13F2N3OPurezza:97.36%Colore e forma:SolidPeso molecolare:301.29DMT-2′Fluoro-dU Phosphoramidite
CAS:DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) can be used to modify nucleosides.Formula:C39H46FN4O8PPurezza:99.5%Colore e forma:SolidPeso molecolare:748.78Cdk5 Substrate acetate
<p>Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.</p>Formula:C55H103N15O14Purezza:96.21%Colore e forma:SolidPeso molecolare:1198.5Acelarin
CAS:<p>Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.</p>Formula:C25H27F2N4O8PPurezza:99.26%Colore e forma:SolidPeso molecolare:580.47Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purezza:98% - 99.8%Colore e forma:SolidPeso molecolare:588.66CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurezza:97.36% - 97.59%Colore e forma:SolidPeso molecolare:368.46Dalpiciclib
CAS:<p>Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.</p>Formula:C25H30N6O2Purezza:99.69%Colore e forma:SolidPeso molecolare:446.54EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Formula:C25H29Cl2F3N2O4SPurezza:98.39% - 99.42%Colore e forma:SolidPeso molecolare:581.474μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formula:C11H8O4Purezza:97.48% - 98.45%Colore e forma:SolidPeso molecolare:204.18PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formula:C20H27F2N5O4SPurezza:98.77% - 99.55%Colore e forma:SolidPeso molecolare:471.52Isoindigotin
CAS:<p>Isoindigotin is used in the therapy of Y.</p>Formula:C16H10N2O2Purezza:98.14% - ≥95%Colore e forma:SolidPeso molecolare:262.26Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFormula:C24H26N4O5SPurezza:99.00% - 99.86%Colore e forma:SolidPeso molecolare:482.55JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formula:C24H33ClN6O2SPurezza:99.96% - 99.96%Colore e forma:SolidPeso molecolare:505.08Orbofiban
CAS:Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.Formula:C17H23N5O4Colore e forma:SolidPeso molecolare:361.4Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Formula:C7H7NO4Purezza:99.83%Colore e forma:SolidPeso molecolare:169.13SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormula:C15H19Br2ClN4Purezza:98.13% - 98.47%Colore e forma:SolidPeso molecolare:450.6Verosudil hydrochloride
CAS:Verosudil (AR-12286) is a selective Rho kinase inhibitor, reducing IOP in XFS & OHT/XFG, offering a new treatment option.Formula:C17H18ClN3O2SColore e forma:SolidPeso molecolare:363.86Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurezza:99.09% - 99.53%Colore e forma:SolidPeso molecolare:340.42Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formula:C31H35Cl3N8O5Purezza:99.69%Colore e forma:SolidPeso molecolare:706.02DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:<p>DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.</p>Formula:C41H49N4O9PPurezza:98.28%Colore e forma:SolidPeso molecolare:772.82kb-NB77-78
CAS:<p>kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).</p>Formula:C18H25NO3SiPurezza:99.54%Colore e forma:SolidPeso molecolare:331.48ML-7 hydrochloride
CAS:ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM);Formula:C15H18ClIN2O2SPurezza:99% - 99.26%Colore e forma:White PowderPeso molecolare:452.74T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purezza:98.39% - 99.57%Colore e forma:SolidPeso molecolare:389.333-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Formula:C10H13NO6Purezza:99.86%Colore e forma:SolidPeso molecolare:243.21THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formula:C31H28ClN7O2Purezza:97.42% - 99.27%Colore e forma:SolidPeso molecolare:566.05MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formula:C25H15ClF2N4O2Purezza:98.07% - 98.26%Colore e forma:SolidPeso molecolare:476.86CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurezza:98.28% - 99.93%Colore e forma:SolidPeso molecolare:379.34Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purezza:97.1% - 99.33%Colore e forma:SolidPeso molecolare:558.70GW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formula:C20H11Cl2NO4Purezza:98.23%Colore e forma:SolidPeso molecolare:400.21BMS-8
CAS:<p>BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.</p>Formula:C27H28BrNO3Purezza:98.88%Colore e forma:SolidPeso molecolare:494.42SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurezza:97.98% - >99.99%Colore e forma:SolidPeso molecolare:335.35CKI-7 free base
CAS:CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formula:C11H12ClN3O2SColore e forma:SolidPeso molecolare:285.75Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurezza:98.8%Colore e forma:SolidPeso molecolare:387.436-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formula:C10H12N4O4SPurezza:97.74%Colore e forma:SolidPeso molecolare:284.29THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Formula:C31H29Cl2N7O2Colore e forma:SolidPeso molecolare:602.51Chroman 1 dihydrochloride
Chroman 1 dihydrochloride: potent ROCK2 inhibitor (IC50: 1 pM), also affects ROCK1 (52 pM) and MRCK (150 nM).Formula:C24H30Cl2N4O4Colore e forma:SolidPeso molecolare:509.43CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:408.88MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Formula:C25H14ClF2N4NaO2Colore e forma:SolidPeso molecolare:498.84CC-671
CAS:<p>CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.</p>Formula:C28H28N6O4Purezza:98.66% - 98.8%Colore e forma:SolidPeso molecolare:512.56A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formula:C15H12N2OS2Purezza:98.07% - 98.52%Colore e forma:SolidPeso molecolare:300.4
