Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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HA-1004
CAS:HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.Formula:C12H15N5O2SPurezza:99.56% - 99.63%Colore e forma:SolidPeso molecolare:293.34GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formula:C22H23ClN6O2Purezza:99.37%Colore e forma:SolidPeso molecolare:438.91ITX3
CAS:ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Formula:C22H17N3OSPurezza:97.28%Colore e forma:SolidPeso molecolare:371.45GS-6620 PM
CAS:GS-6620 PM, oral Hep C polymerase inhibitor prodrug, is a potent GS-6620 derivative with limited activity against other viruses.Formula:C13H15N5O4Purezza:98.52% - 98.7%Colore e forma:SolidPeso molecolare:305.29COH34
CAS:COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM.Formula:C18H15NOSPurezza:99.57%Colore e forma:SolidPeso molecolare:293.38(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formula:C20H27F2N5O4SPurezza:98.59%Colore e forma:SolidPeso molecolare:471.52CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formula:C18H19ClFN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:363.81Ryuvidine
CAS:Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.Formula:C15H12N2O2SPurezza:98.6%Colore e forma:SolidPeso molecolare:284.33GKI-1
CAS:<p>GKI-1, a GWL kinase inhibitor: IC50 - 4.9 µM for hGWLFL, 2.5 µM for hGWL-KinDom, 11 µM for ROCK1; weak on PKA.</p>Formula:C15H12ClN3Purezza:99.96%Colore e forma:SolidPeso molecolare:269.73CF-1743
CAS:<p>CF-1743 is an anti-varicella zoster virus nucleoside and inhibits VZV replication.</p>Formula:C22H26N2O5Purezza:99.6% - 99.79%Colore e forma:SolidPeso molecolare:398.45UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Formula:C17H17N3SPurezza:99.86%Colore e forma:SolidPeso molecolare:295.4Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Formula:C12H11N5OPurezza:99.27% - 99.9%Colore e forma:SolidPeso molecolare:241.25D-I03
CAS:D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.Formula:C23H36N6SPurezza:99.65%Colore e forma:SolidPeso molecolare:428.64Talotrexin ammonium
CAS:<p>Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.</p>Formula:C27H30N10O6Purezza:97.49%Colore e forma:SolidPeso molecolare:590.59AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Formula:C21H22F3N5O4Purezza:99.97%Colore e forma:SolidPeso molecolare:465.439-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formula:C17H22N6OPurezza:99.82%Colore e forma:SolidPeso molecolare:326.4ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Formula:C20H19N3O3Purezza:99.85%Colore e forma:SolidPeso molecolare:349.38Anticancer agent 73
CAS:Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Formula:C14H15NO4Purezza:99.56%Colore e forma:SolidPeso molecolare:261.27AzddMeC
CAS:AzddMeC (Az-Dcme) is an HIV-1 reverse transcriptase and HIV-1 replication inhibitor with antiretroviral activity.AzddMeC is used in the study of HIV-1 infectionFormula:C10H14N6O3Purezza:97.14% - 99.62%Colore e forma:SolidPeso molecolare:266.26Galocitabine
CAS:Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.Formula:C19H22FN3O8Purezza:99.89%Colore e forma:SolidPeso molecolare:439.39L82
CAS:L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.Formula:C11H8ClN5O4Purezza:98.06% - 98.91%Colore e forma:SolidPeso molecolare:309.67Netivudine
CAS:<p>Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.</p>Formula:C12H14N2O6Purezza:99.78%Colore e forma:SolidPeso molecolare:282.25DENV-IN-5
CAS:Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.Formula:C23H25ClF2N4OSPurezza:99.42%Colore e forma:SolidPeso molecolare:478.99TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purezza:99.516%Colore e forma:SolidPeso molecolare:359.38DDRI-18
CAS:DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Formula:C26H20N6Purezza:98%Colore e forma:SolidPeso molecolare:416.48NSC16168
CAS:NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.Formula:C17H15NO9S3Purezza:99.88%Colore e forma:SolidPeso molecolare:473.5AGX51
CAS:AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.Formula:C27H29NO4Purezza:97.65%Colore e forma:OilPeso molecolare:431.52SB-747651A Dihydrochloride
CAS:SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formula:C16H24Cl2N8OPurezza:98.05%Colore e forma:SolidPeso molecolare:415.32Talviraline
CAS:Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in aFormula:C15H20N2O3S2Purezza:99.88%Colore e forma:SolidPeso molecolare:340.46Eprociclovir
CAS:Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention ofFormula:C11H15N5O3Purezza:98.50% - 99.86%Colore e forma:SolidPeso molecolare:265.27Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formula:C27H21N3O3Purezza:99.22%Colore e forma:SolidPeso molecolare:435.47Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Formula:C14H11BrN4O3SPurezza:97.27%Colore e forma:SolidPeso molecolare:395.236-Hydroxy-DOPA
CAS:<p>6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.</p>Formula:C9H11NO5Purezza:97.78% - 97.95%Colore e forma:SolidPeso molecolare:213.19PCSK9-IN-10
CAS:<p>PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.</p>Formula:C18H23N5O4Purezza:99.06%Colore e forma:SoildPeso molecolare:373.41PS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formula:C25H23F3O9Purezza:98.81% - 99.26%Colore e forma:SolidPeso molecolare:524.44116-9e
CAS:116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.Formula:C31H32N2O5Purezza:99.55%Colore e forma:SolidPeso molecolare:512.6RP-6306
CAS:<p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>Formula:C18H20N4O2Purezza:98.41% - 99.28%Colore e forma:SolidPeso molecolare:324.38dCeMM2
CAS:dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.Formula:C16H11ClN6OSPurezza:99.68%Colore e forma:SolidPeso molecolare:370.82SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formula:C15H18Br2N4Purezza:99.764% - 99.84%Colore e forma:SolidPeso molecolare:414.14RP-6685
CAS:RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Formula:C22H14F7N5OPurezza:99.65%Colore e forma:SoildPeso molecolare:497.37CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurezza:98.78%Colore e forma:SolidPeso molecolare:405.46Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Formula:C6H11N3O4Purezza:99.8%Colore e forma:SolidPeso molecolare:189.17CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formula:C28H30F2N6Purezza:97.25% - 99.72%Colore e forma:SolidPeso molecolare:488.57Haspin-IN-3
CAS:<p>Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.</p>Formula:C16H10N2O3Purezza:98.78%Colore e forma:SolidPeso molecolare:278.26Cytembena
CAS:Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Formula:C11H8BrNaO4Purezza:99.7%Colore e forma:White PowderPeso molecolare:307.07EHT 1610
CAS:EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Formula:C18H14FN5O2SPurezza:98.43%Colore e forma:SolidPeso molecolare:383.46RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formula:C13H17N5O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:307.37Cdc7-IN-7c
CAS:<p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>Formula:C15H17N5OSPurezza:98.19% - 99.22%Colore e forma:SolidPeso molecolare:315.39CMX-521
CAS:CMX521: an antiviral for norovirus, effective against rotavirus; inhibits viral RNA polymerase.Formula:C13H17N5O5Purezza:99.57%Colore e forma:SolidPeso molecolare:323.3hDHODH-IN-7
CAS:hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Formula:C21H23FN4OPurezza:99.87%Colore e forma:SolidPeso molecolare:366.43
