Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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IIP0943
CAS:IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.Formula:C26H28N6O3SColore e forma:SolidPeso molecolare:504.604RECTAS-2.0
CAS:<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formula:C18H17ClN4O4Colore e forma:SolidPeso molecolare:388.805RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formula:C35H40N8O2Colore e forma:SolidPeso molecolare:604.74WEE1/PKMYT1-IN-1
CAS:<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Formula:C16H16N4O3Colore e forma:SolidPeso molecolare:312.3235-Iminodaunorubicin hydrochloride
CAS:<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Formula:C27H31ClN2O9Colore e forma:SolidPeso molecolare:563.00PCNA-IN-1
CAS:PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formula:C19H18I3NO3Colore e forma:SolidPeso molecolare:689.065RAD51-IN-7
CAS:RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Formula:C25H31N5O4S2Colore e forma:SolidPeso molecolare:529.67T-2513 hydrochloride
CAS:T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Formula:C25H28ClN3O5Colore e forma:SolidPeso molecolare:485.962-CEES
CAS:2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Formula:C4H9ClSColore e forma:SolidPeso molecolare:124.632Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Formula:C27H32N6O4Colore e forma:SolidPeso molecolare:504.58DDO-6079
CAS:DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76Cdc7-IN-10
CAS:Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48Z4P
CAS:Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Formula:C19H24N2O2Purezza:98.99%Colore e forma:SolidPeso molecolare:312.41WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formula:C28H30Cl2N8OPurezza:98.18%Colore e forma:SolidPeso molecolare:565.5Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Colore e forma:SolidPeso molecolare:437.612-Amino-2'-fluoro-2'-deoxyadenosine
CAS:<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Formula:C10H13FN6O3Colore e forma:SolidPeso molecolare:284.25Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formula:C18H26Cl2N4O3SColore e forma:SolidPeso molecolare:449.39Haspin-IN-2
CAS:<p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>Formula:C12H8N4O3Colore e forma:SolidPeso molecolare:256.22KL-50
CAS:KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.Formula:C7H7FN6O2Colore e forma:SolidPeso molecolare:226.17Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formula:C16H20N6OColore e forma:SolidPeso molecolare:312.37Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.403′-Amino-2′,3′-dideoxy-CTP
CAS:3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.Formula:C9H17N4O12P3Colore e forma:SolidPeso molecolare:466.17APE1-IN-3
CAS:<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formula:C17H16O4Colore e forma:SolidPeso molecolare:284.31PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formula:C22H19N5O2Colore e forma:SolidPeso molecolare:385.42L-I-OddU
CAS:<p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>Formula:C8H9IN2O5Colore e forma:SolidPeso molecolare:340.07CDK7-IN-17
CAS:CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.Formula:C24H26F3N6OPPurezza:99.60%Colore e forma:SolidPeso molecolare:502.473-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS:Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Formula:C17H19FO7Peso molecolare:354.33TASIN-30
CAS:<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Formula:C18H30N2O3SColore e forma:SolidPeso molecolare:354.51CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formula:C25H34N8OColore e forma:SolidPeso molecolare:462.59Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formula:C25H38O4Colore e forma:SolidPeso molecolare:402.57DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formula:C18H26N4O3SColore e forma:SoildPeso molecolare:378.49Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formula:C37H37N5O7Colore e forma:SolidPeso molecolare:663.72CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formula:C17H21BrN4OPurezza:98%Colore e forma:SolidPeso molecolare:377.28PD-1-IN-17
CAS:PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Formula:C13H22N6O7Purezza:99.6%Colore e forma:SolidPeso molecolare:374.35Aurora A inhibitor 4
CAS:Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Formula:C22H23N5O3Peso molecolare:405.45D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formula:C19H22N4O3Colore e forma:SolidPeso molecolare:354.403Antibacterial agent 110
Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).Formula:C22H21N5O4SColore e forma:SolidPeso molecolare:451.5LIMK1 inhibitor 2
CAS:LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Formula:C10H11N3OSColore e forma:SolidPeso molecolare:221.279Norharmine
CAS:Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.Formula:C12H10N2OColore e forma:SolidPeso molecolare:198.2215-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Formula:C9H12FN2O9PColore e forma:SolidPeso molecolare:342.172Protein kinase inhibitor 14
CAS:Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects on various serine/threonine kinases and receptor/non-receptor tyrosine kinases.Formula:C22H22F2N6OPeso molecolare:424.447Cdc7-IN-11
CAS:Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48Y-99
CAS:Y-99 is a PORCN inhibitor with an IC50 value of 155.4 nM for suppressing the Wnt/β-catenin signaling pathway. Additionally, Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc.Formula:C18H17F2N5O3Colore e forma:SolidPeso molecolare:389.36Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Formula:C9H20N2O8Colore e forma:SolidPeso molecolare:284.26BAY-364
CAS:BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Formula:C23H19N3O4Colore e forma:SolidPeso molecolare:401.41Anti-neuroinflammation agent 3
CAS:Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Formula:C22H23FN6O2Peso molecolare:422.455MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Formula:C23H24ClN3O3Colore e forma:SolidPeso molecolare:425.91CDK7-IN-33
CAS:CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Formula:C29H36N6O4SColore e forma:SolidPeso molecolare:564.699Polθ-IN-8
CAS:Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.Formula:C22H22ClN7O3SColore e forma:SolidPeso molecolare:499.97MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Formula:C22H24N4O3Colore e forma:SolidPeso molecolare:392.45
