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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"

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  • 7-Methylguanosine 5′-monophosphate
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    7-Methylguanosine 5′-monophosphate

    CAS:
    7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.
    Formula:C11H16N5O8P
    Colore e forma:Solid
    Peso molecolare:377.25

    Ref: TM-TSW-00951

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    ddCTP trisodium

    ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.
    Formula:C9H13N3Na3O12P3
    Colore e forma:Solid
    Peso molecolare:517.1

    Ref: TM-T63602

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    DNA gyrase B-IN-1

    DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.
    Formula:C23H18ClF3N6O4S
    Colore e forma:Solid
    Peso molecolare:566.94

    Ref: TM-T64012

  • Antifolate agent 1
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    Antifolate agent 1

    CAS:
    Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.
    Formula:C19H19N5O6
    Colore e forma:Solid
    Peso molecolare:413.38

    Ref: TM-T212452

  • AM-9022
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    AM-9022

    CAS:
    AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].
    Formula:C27H36F2N6O4S
    Colore e forma:Solid
    Peso molecolare:578.67

    Ref: TM-T85640

  • p38α inhibitor 9
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    p38α inhibitor 9

    CAS:
    p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.
    Formula:C27H24FN3O3
    Colore e forma:Solid
    Peso molecolare:457.496

    Ref: TM-T206722

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Colore e forma:Solid
    Peso molecolare:485.49

    Ref: TM-T87635

  • USP7-797
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    USP7-797

    CAS:
    USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.
    Formula:C27H28ClN3O3S
    Purezza:95.90%
    Colore e forma:Solid
    Peso molecolare:510.05

    Ref: TM-T73234

  • DENV-IN-6
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    DENV-IN-6

    CAS:
    DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.
    Formula:C23H26ClFN4OS
    Colore e forma:Solid
    Peso molecolare:461

    Ref: TM-T62908

  • PD-L1-IN-7
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    PD-L1-IN-7

    CAS:
    PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.
    Formula:C46H50N6O7
    Colore e forma:Solid
    Peso molecolare:798.93

    Ref: TM-T89952

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    CDK2-IN-8

    CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.
    Formula:C22H25N5O3
    Colore e forma:Solid
    Peso molecolare:407.47

    Ref: TM-T62038

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    CDK8-IN-11 hydrochloride

    CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.
    Formula:C19H16ClF3N4O2
    Colore e forma:Solid
    Peso molecolare:424.8

    Ref: TM-T62293

  • SR121566A
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    SR121566A

    CAS:
    SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).
    Formula:C20H25N5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:431.51

    Ref: TM-T12999

  • FR-145715
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    FR-145715

    CAS:
    FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.
    Formula:C16H21N5O2S
    Colore e forma:Solid
    Peso molecolare:347.44

    Ref: TM-T201582

  • GTSE1-IN-1
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    GTSE1-IN-1

    CAS:
    GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.
    Formula:C21H24FN7
    Colore e forma:Solid
    Peso molecolare:393.46

    Ref: TM-T200127

  • Logo CymitQuimica
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    DNA Gyrase-IN-1

    DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.
    Formula:C24H24FN7O6
    Colore e forma:Solid
    Peso molecolare:525.49

    Ref: TM-T63681

  • DB18
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    DB18

    CAS:
    DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].
    Formula:C24H18ClN7O3
    Colore e forma:Solid
    Peso molecolare:487.9

    Ref: TM-T86165

  • CIB-L43
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    CIB-L43

    CAS:
    <p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>
    Formula:C15H16N2O3S
    Purezza:99.64%
    Colore e forma:Solid
    Peso molecolare:304.36

    Ref: TM-T205607

  • TY-011
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    TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Formula:C18H16ClN5
    Colore e forma:Solid
    Peso molecolare:337.81

    Ref: TM-T89833

  • 3-IN-PP1
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    3-IN-PP1

    CAS:
    3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.
    Formula:C17H18N6
    Colore e forma:Solid
    Peso molecolare:306.36

    Ref: TM-T60718