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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"

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  • DNA Gyrase-IN-16
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    DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Formula:C17H15N3O3
    Colore e forma:Solid
    Peso molecolare:309.319

    Ref: TM-T205315

  • BRD4 Inhibitor-40
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    BRD4 Inhibitor-40

    CAS:
    BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.
    Formula:C27H32N8O
    Colore e forma:Solid
    Peso molecolare:484.596

    Ref: TM-T205510

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.
    Formula:C25H30FN7O
    Colore e forma:Solid
    Peso molecolare:463.55

    Ref: TM-T205073

  • HNC-1664
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    HNC-1664

    CAS:
    HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.
    Formula:C12H13FIN3O3
    Colore e forma:Solid
    Peso molecolare:393.153

    Ref: TM-T205157

  • Logo CymitQuimica
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    IRE1α kinase-IN-5

    IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.
    Formula:C28H30N6O3S
    Colore e forma:Solid
    Peso molecolare:530.64

    Ref: TM-T63734

  • 2′-O-MOE-CMP
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    2′-O-MOE-CMP

    CAS:
    2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.
    Formula:C12H20N3O9P
    Colore e forma:Solid
    Peso molecolare:381.28

    Ref: TM-TSW-00960

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.
    Formula:C23H22F5N5O3
    Colore e forma:Solid
    Peso molecolare:511.44

    Ref: TM-T207287

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Formula:C13H8FN3O3
    Colore e forma:Solid
    Peso molecolare:273.219

    Ref: TM-T204415

  • LZ9
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    LZ9

    CAS:
    LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.
    Formula:C17H11F3N4O2
    Colore e forma:Solid
    Peso molecolare:360.29

    Ref: TM-T204957

  • PNR-3-80
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    PNR-3-80

    CAS:
    PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
    Formula:C24H14ClN3O3S
    Colore e forma:Solid
    Peso molecolare:459.90

    Ref: TM-T212403

  • CDK2 degrader 4
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    CDK2 degrader 4

    CAS:
    CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.
    Formula:C23H26ClN3O5
    Colore e forma:Solid
    Peso molecolare:459.923

    Ref: TM-T204856

  • Dyrk1A-IN-12
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    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Formula:C22H16FN3O2S
    Colore e forma:Solid
    Peso molecolare:405.445

    Ref: TM-T205530

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.
    Formula:C28H24FN5O5
    Colore e forma:Solid
    Peso molecolare:529.519

    Ref: TM-T205482

  • EX05
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    EX05

    CAS:
    EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.
    Formula:C26H30F2N4O5S
    Colore e forma:Solid
    Peso molecolare:548.60

    Ref: TM-T88621

  • Logo CymitQuimica
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    Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition
    Formula:C23H22N4O2
    Colore e forma:Solid
    Peso molecolare:386.45

    Ref: TM-T61720

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].
    Formula:C9H10FN3O3
    Colore e forma:Solid
    Peso molecolare:227.19

    Ref: TM-T60285

  • Valopicitabine dihydrochloride
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    Valopicitabine dihydrochloride

    CAS:
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C15H25ClN4O6
    Colore e forma:Solid
    Peso molecolare:392.84

    Ref: TM-T29094

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)
    Formula:C25H28ClF2N5O2
    Colore e forma:Solid
    Peso molecolare:503.97

    Ref: TM-T63436

  • CB 30900
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    CB 30900

    CAS:
    CB30900 is a novel and effective thymidylate synthase inhibitor.
    Formula:C31H32FN5O9
    Colore e forma:Solid
    Peso molecolare:637.61

    Ref: TM-T30760

  • Logo CymitQuimica
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    Antitumor agent-75

    Antitumor agent-75 is a novel and potent antitumor agent.
    Formula:C26H23FN6
    Colore e forma:Solid
    Peso molecolare:438.5

    Ref: TM-T62510