Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2409 prodotti di "Cromatina/Epigenetica"
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Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formula:C25H26F2N6O2Purezza:99.58%Colore e forma:SoildPeso molecolare:480.51LIN28 inhibitor LI71
CAS:<p>LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.</p>Formula:C21H21NO3Purezza:95.88%Colore e forma:SolidPeso molecolare:335.4Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C21H20FN7Purezza:98.4% - 99.01%Colore e forma:SolidPeso molecolare:389.43Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formula:C22H24ClNO4Purezza:99.53%Colore e forma:SolidPeso molecolare:401.88NU6140
CAS:<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Formula:C23H30N6O2Purezza:98.33%Colore e forma:SolidPeso molecolare:422.52Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFormula:C8H14N2O2Purezza:99.67% - 99.86%Colore e forma:White Crystalline PowderPeso molecolare:170.21Bendazol
CAS:<p>Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.</p>Formula:C14H12N2Purezza:98.7% - 99.87%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:208.26Cyproheptadine hydrochloride sesquihydrate
CAS:Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2.Formula:C21H24ClNOPurezza:99.77% - >99.99%Colore e forma:White To Slightly Yellowish Crystalline SolidPeso molecolare:341.88Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Formula:C9H16N4O7Purezza:>99.99%Colore e forma:SolidPeso molecolare:292.25Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Formula:C26H34ClN3O4Purezza:98.38% - 99.83%Colore e forma:SolidPeso molecolare:488.02Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Formula:C120H199N45O34S2Purezza:99.96%Colore e forma:SolidPeso molecolare:2880.28Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Formula:C26H29F3N5O7PPurezza:99.75% - 99.79%Colore e forma:SolidPeso molecolare:611.51JAK2 Inhibitor V
CAS:<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Formula:C23H24N2OPurezza:98.36% - 99.15%Colore e forma:SolidPeso molecolare:344.45ZEN-3694
CAS:ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and canFormula:C19H19N5OPurezza:98.94% - 99.76%Colore e forma:SolidPeso molecolare:333.39Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formula:C11H15N2O5Purezza:98.82% - 99.58%Colore e forma:SolidPeso molecolare:255.25Nefiracetam
CAS:Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.Formula:C14H18N2O2Purezza:97.37%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:246.3MS31 trihydrochloride (2366264-12-0 free base)
<p>MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor</p>Formula:C20H30Cl3N3O2Purezza:99.69%Colore e forma:SolidPeso molecolare:450.83Histone Acetyltransferase Inhibitor II
CAS:Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activityFormula:C20H16Br2O3Purezza:97.13%Colore e forma:SolidPeso molecolare:464.15HIF-2α-IN-2
CAS:<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Formula:C17H13F2NO4SPurezza:99.24%Colore e forma:SolidPeso molecolare:365.35AW68
CAS:AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.Formula:C22H21ClN6Purezza:98.52% - 98.52%Colore e forma:SoildPeso molecolare:404.89Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurezza:99.77%Colore e forma:White Solid CrystallinePeso molecolare:215.63Glucosamine
CAS:<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Formula:C6H13NO5Purezza:99.8% - 99.8%Colore e forma:CoaPeso molecolare:179.17Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C21H21ClFN7Purezza:99.55%Colore e forma:SolidPeso molecolare:425.89mTOR/HDAC-IN-1 HCl
mTOR/HDAC-IN-1 HCl，a dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagic and apoptosis-inducing effects for cancerFormula:C23H24ClN11O3Purezza:99.56%Colore e forma:SoildPeso molecolare:537.96Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purezza:99.28% - >99.99%Colore e forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecolare:493.94Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFormula:C28H36ClN3O5SPurezza:98.04% - 99.872%Colore e forma:SolidPeso molecolare:562.12PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Purezza:95.42%Colore e forma:SoildPulrodemstat benzenesulfonate
CAS:Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally inhibitor of lysine specific demethylase-1 (LSD1) with anticancer effect.Formula:C30H29F2N5O5SPurezza:97.67%Colore e forma:SolidPeso molecolare:609.64SMARCA-BD ligand 1 for Protac
CAS:<p>SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2</p>Formula:C14H17N5OPurezza:99.93%Colore e forma:SolidPeso molecolare:271.32Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formula:C5H15N2O3PSPurezza:99.59%Colore e forma:White SolidPeso molecolare:214.22Miltefosine
CAS:<p>Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.</p>Formula:C21H46NO4PPurezza:98% - 99.87%Colore e forma:White To Off-White PowderPeso molecolare:407.57DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formula:C25H25N3OPurezza:98.95%Colore e forma:SolidPeso molecolare:383.49TAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formula:C28H32N4O3SPurezza:99.02% - 99.59%Colore e forma:SolidPeso molecolare:504.64Indoprofen
CAS:Indoprofen ((±)-Indoprofe) is a non-steroidal anti-inflammatory drug.Formula:C17H15NO3Purezza:99.34%Colore e forma:SolidPeso molecolare:281.31Ilginatinib maleate
CAS:<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formula:C25H24FN7O4Purezza:99.74% - 99.82%Colore e forma:SolidPeso molecolare:505.5Phenelzine sulfate
CAS:Phenelzine sulfate is a non-selective and irreversible inhibitor of monoamine oxidase (MAOI), and with antidepressant and anxiolytic.Formula:C8H14N2O4SPurezza:98.38% - 99.83%Colore e forma:SolidPeso molecolare:234.27MK8722
CAS:MK8722 is an effective and systemic activator of pan-AMPK.Formula:C24H20ClN3O4Purezza:98.08% - 99.8800%Colore e forma:SolidPeso molecolare:449.89Hydroxycitric acid tripotassium hydrate
CAS:Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Formula:C6H7K3O8Purezza:99.85%Colore e forma:White Solid CrystallinePeso molecolare:324.41EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Formula:C34H48N4O4Purezza:99.74%Colore e forma:SolidPeso molecolare:576.77MOZ-IN-2
CAS:<p>MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).</p>Formula:C17H13FN4O3SPurezza:99.17%Colore e forma:SolidPeso molecolare:372.37FIDAS-3
CAS:FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activitiesFormula:C16H15F2NPurezza:97.75%Colore e forma:SolidPeso molecolare:259.29Molidustat
CAS:Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。Formula:C13H14N8O2Purezza:98.79%Colore e forma:SolidPeso molecolare:314.3N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Formula:C25H28ClNOPurezza:99.15%Colore e forma:SolidPeso molecolare:393.95A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Formula:C26H35FN4O2SPurezza:98.43%Colore e forma:SolidPeso molecolare:486.65Inobrodib
CAS:Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.Formula:C30H32F2N4O3Purezza:98.91% - 99.18%Colore e forma:SolidPeso molecolare:534.6SNDX-5613
CAS:Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurezza:99.12% - 99.74%Colore e forma:SolidPeso molecolare:630.82SYP-5
CAS:SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Formula:C18H16O3SPurezza:98.31%Colore e forma:SolidPeso molecolare:312.38Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formula:C26H52N6O11SPurezza:94.68% - 99.8%Colore e forma:SolidPeso molecolare:656.79BRM/BRG1 ATP Inhibitor-1
CAS:<p>BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member</p>Formula:C11H9F3N4O2SPurezza:98.17% - 99.84%Colore e forma:SolidPeso molecolare:318.27EML 425
CAS:EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).Formula:C27H24N2O4Purezza:97.6%Colore e forma:SolidPeso molecolare:440.49Curcumin
CAS:Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formula:C21H20O6Purezza:95% - 98.98%Colore e forma:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Peso molecolare:368.38Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formula:C12H15N3O2SPurezza:98.21% - 98.76%Colore e forma:Colorless Crystals SolidPeso molecolare:265.33MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Formula:C20H17FN6OPurezza:98.25% - 99.92%Colore e forma:SolidPeso molecolare:376.39Hydralazine hydrochloride
CAS:Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Formula:C8H9ClN4Purezza:99.85% - 99.86%Colore e forma:Yellow Crystals White Crystalline SolidPeso molecolare:196.64WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Formula:C13H8Cl2N2O2SPurezza:99.69%Colore e forma:SoildPeso molecolare:327.19TRIM24/BRPF1-IN-2
CAS:<p>TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.</p>Formula:C20H22N2O4SPurezza:98.69% - 99.13%Colore e forma:SoildPeso molecolare:386.47Diflunisal
CAS:Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.Formula:C13H8F2O3Purezza:98.92% - 99.42%Colore e forma:SolidPeso molecolare:250.20Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Formula:C12H17NO3Purezza:99.73%Colore e forma:Acicular CrystalPeso molecolare:223.27iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Formula:C22H24ClN3O2SPurezza:99.53% - 99.89%Colore e forma:SoildPeso molecolare:429.96PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formula:C17H10F5NO4SPurezza:98.8% - 99.45%Colore e forma:SolidPeso molecolare:419.32MAT2A inhibitor 2
CAS:<p>MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).</p>Formula:C18H24ClN3O3Purezza:99.52%Colore e forma:SolidPeso molecolare:365.85ODM-207
CAS:ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.Formula:C22H21N3O3Purezza:99.75%Colore e forma:SolidPeso molecolare:375.42(R)-CR8
CAS:<p>(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.</p>Formula:C24H29N7OPurezza:98.41%Colore e forma:SolidPeso molecolare:431.53A-485
CAS:<p>A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.</p>Formula:C25H24F4N4O5Purezza:98.01% - 99.44%Colore e forma:SolidPeso molecolare:536.48Chitosan oligosaccharide
CAS:Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine.Formula:C12H24N2O9Purezza:98%Colore e forma:SolidPeso molecolare:340.327L-2-Hydroxyglutaric acid disodium
CAS:L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).Formula:C5H6Na2O5Purezza:99.92%Colore e forma:SolidPeso molecolare:192.08ZL0580
CAS:ZL0580 suppresses HIV by blocking Tat activation, halting transcription, and promoting repressive chromatin at the HIV promoter.Formula:C25H23F3N4O4SPurezza:99.70%Colore e forma:SolidPeso molecolare:532.53EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formula:C28H35NO3Purezza:98.36%Colore e forma:SolidPeso molecolare:433.58Brepocitinib P-Tosylate
CAS:<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formula:C25H29F2N7O4SPurezza:99.82% - 99.97%Colore e forma:SolidPeso molecolare:561.6Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Formula:C22H28ClN3O4Purezza:99.91%Colore e forma:SolidPeso molecolare:433.93N-(3-Aminopropyl)cyclohexylamine
CAS:N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Formula:C9H20N2Purezza:98.05% - 98.82%Colore e forma:Pale Yellow Clear LiquidPeso molecolare:156.2685NI-42
CAS:NI-42, a BRPFs inhibitor: IC50(BRPF1/2/3)=7.9/48/260 nM, Kd(BRPF1/2/3)=40/210/940 nM; selective for class IV BRDs.Formula:C18H15N3O3SPurezza:99.18%Colore e forma:SolidPeso molecolare:353.39CBP/p300-IN-3
CAS:CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.Formula:C24H29N7OPurezza:97.38% - 98.08%Colore e forma:SolidPeso molecolare:431.53Gusacitinib
CAS:<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Formula:C24H28N8O2Purezza:98.06% - 99.94%Colore e forma:SolidPeso molecolare:460.53BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Formula:C14H11NO3Purezza:98.87%Colore e forma:SolidPeso molecolare:241.24Tinengotinib
CAS:Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formula:C20H19ClN6OPurezza:99.05%Colore e forma:SolidPeso molecolare:394.86T-3775440 hydrochloride
CAS:<p>T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).</p>Formula:C18H23ClN4OPurezza:99.88%Colore e forma:SolidPeso molecolare:346.85Niraparib (R-enantiomer)
CAS:<p>Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).</p>Formula:C19H20N4OPurezza:99.83%Colore e forma:SolidPeso molecolare:320.39Citric acid trilithium salt tetrahydrate
CAS:Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFormula:C6H13Li3O11Purezza:99.88%Colore e forma:White Crystalline PowderPeso molecolare:281.98Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formula:C11H12Cl2N2O5Purezza:99.6% - 99.84%Colore e forma:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecolare:323.13Decitabine
CAS:<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formula:C8H12N4O4Purezza:98.06% - 99.87%Colore e forma:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecolare:228.21Enarodustat
CAS:<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Formula:C17H16N4O4Purezza:99.73% - 99.75%Colore e forma:SolidPeso molecolare:340.33RBN-2397
CAS:RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.Formula:C20H23F6N7O3Purezza:98.48% - 99.8%Colore e forma:SolidPeso molecolare:523.43Ziftomenib
CAS:<p>Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.</p>Formula:C33H42F3N9O2S2Purezza:99.65%Colore e forma:SolidPeso molecolare:717.871BRD4 Inhibitor-10
CAS:<p>BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).</p>Formula:C25H27N5O2Purezza:99.53%Colore e forma:SolidPeso molecolare:429.51Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purezza:99% - 99.88%Colore e forma:SolidPeso molecolare:352.34Tranylcypromine (2-PCPA) hydrochloride
CAS:<p>Tranylcypromine (2-PCPA) HCl, a MAO inhibitor, treats major, dysthymic, and atypical depression.</p>Formula:C9H11N·HClPurezza:99.48% - 99.86%Colore e forma:SolidPeso molecolare:169.66GNE-781
CAS:GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).Formula:C27H33F2N7O2Purezza:99.25% - 99.64%Colore e forma:SolidPeso molecolare:525.59Lin28-let-7a antagonist 1
CAS:Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.Formula:C31H29N5O7Purezza:99.44%Colore e forma:SolidPeso molecolare:583.59Golidocitinib
CAS:Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formula:C25H31N9O2Purezza:98.87% - 99.88%Colore e forma:SolidPeso molecolare:489.57dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purezza:99.44%Colore e forma:SolidPeso molecolare:1071.93Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formula:C14H17N3O3Purezza:99.81%Colore e forma:SoildPeso molecolare:275.3Amodiaquine dihydrochloride dihydrate
CAS:<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Formula:C20H28Cl3N3O3Purezza:99.97%Colore e forma:SolidPeso molecolare:464.82MS417
CAS:MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weakFormula:C20H19ClN4O2SPurezza:99.87%Colore e forma:SolidPeso molecolare:414.91M-89
CAS:<p>M-89, a potent menin inhibitor (Kd 1.4 nM), disrupts Menin-MLL interaction, offering possible MLL leukemia treatment.</p>Formula:C37H47N5O4SPurezza:98.38%Colore e forma:SolidPeso molecolare:657.87Tilorone dihydrochloride
CAS:<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Formula:C25H36Cl2N2O3Purezza:98% - 99.86%Colore e forma:Orange Yellow Crystal PowderPeso molecolare:483.47PBIT
CAS:<p>PBIT is a JARID1 inhibitor with IC50: 3 μM for JARID1B, 6 μM for JARID1A, and 4.9 μM for JARID1C.</p>Formula:C14H11NOSPurezza:99.61% - 99.83%Colore e forma:SolidPeso molecolare:241.31VTP50469
CAS:VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurezza:98.31% - 99.55%Colore e forma:SolidPeso molecolare:630.82Acetaminophen
CAS:Acetaminophen: pain reliever, fever reducer; mild anti-inflammatory. Risks: liver, kidney damage, blood cell effects.Formula:C8H9NO2Purezza:99.85% - 99.99%Colore e forma:Colourless Solid CrystallinePeso molecolare:151.16L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formula:C15H15NO5SPurezza:98.59%Colore e forma:SolidPeso molecolare:321.35Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formula:C8H6N2S3Purezza:98.79% - 99.77%Colore e forma:SolidPeso molecolare:226.34Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formula:C26H25F2N7O6S2Purezza:98.76%Colore e forma:SolidPeso molecolare:633.65FIDAS-5
CAS:FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Formula:C15H13ClFNPurezza:98.3% - 99.17%Colore e forma:SolidPeso molecolare:261.725-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Formula:C8H12N4O5Purezza:98% - 99.79%Colore e forma:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecolare:244.2Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Formula:C16H18N6OPurezza:99.95%Colore e forma:SolidPeso molecolare:310.35MS402
CAS:MS402 is a novel BD1-selective BET BrD inhibitor.Formula:C20H19ClN2O3Purezza:99.72%Colore e forma:SolidPeso molecolare:370.83BMS-986158
CAS:<p>BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.</p>Formula:C30H33N5O2Purezza:98.78%Colore e forma:SolidPeso molecolare:495.62Miglitol
CAS:Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.Formula:C8H17NO5Purezza:99.75% - 99.88%Colore e forma:White To Pale-Yellow Powder SolidPeso molecolare:207.22N6-Cyclohexyladenosine
CAS:N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm.Formula:C16H23N5O4Purezza:99.92% - 99.98%Colore e forma:SolidPeso molecolare:349.38Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Formula:C15H13N3O2SPurezza:99.74%Colore e forma:White To Yellowish PowderPeso molecolare:299.35SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formula:C39H42FN9O7Colore e forma:SolidPeso molecolare:767.81CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Colore e forma:SolidPeso molecolare:527.06AUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formula:C41H50BrN9O5Purezza:98.84%Colore e forma:SolidPeso molecolare:828.8Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Colore e forma:Odour SolidMenin-KMT2A-IN-1
Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formula:C28H35FN6O3Colore e forma:SolidPeso molecolare:522.61PROTAC BRD4 Degrader-10
CAS:Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5NP213
CAS:NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formula:C42H84N28O7Purezza:98%Colore e forma:SolidPeso molecolare:1093.3ZL0590
CAS:<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Formula:C23H27F3N4O4SPurezza:99.77%Colore e forma:SoildPeso molecolare:512.55SMD-3236
CAS:SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.Formula:C61H75ClN10O5SColore e forma:SolidPeso molecolare:1095.83TCIP3
CAS:<p>TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.</p>Formula:C58H71ClF2N16O7Colore e forma:SolidPeso molecolare:1177.74CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SolidKDM1A-IN-29
CAS:<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formula:C16H16ClN3O4SColore e forma:SoildPeso molecolare:381.83PROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formula:C50H62ClN9O8S2Colore e forma:SolidPeso molecolare:1016.67TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Colore e forma:Odour SolidFluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Colore e forma:SolidSAMS
CAS:SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formula:C74H131N29O18S2Purezza:98%Colore e forma:SolidPeso molecolare:1779.15UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formula:C33H52N6O3Colore e forma:SolidPeso molecolare:580.83β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Formula:C30H52O4Colore e forma:SolidPeso molecolare:476.742PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Colore e forma:SolidPeso molecolare:1118.75Hyp-dBET1
<p>Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.</p>Colore e forma:Odour SolidPumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formula:C17H20N8O2SPurezza:99.94%Colore e forma:SoildPeso molecolare:400.46Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Colore e forma:Odour SolidHDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Colore e forma:Odour SolidHDAC1-IN-9
HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.Formula:C17H17N3O3Colore e forma:SolidPeso molecolare:311.34Uzansertib
CAS:Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formula:C26H26F3N5O3Colore e forma:SolidPeso molecolare:513.51PROTAC BRD4 Degrader-19
CAS:PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormula:C44H38N8O5S2Colore e forma:SolidPeso molecolare:822.95GSK8573
CAS:GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formula:C20H21NO3Purezza:99.97%Colore e forma:SolidPeso molecolare:323.39GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formula:C29H34N4O4Colore e forma:SolidPeso molecolare:502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Purezza:98%Colore e forma:Odour SolidBRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:394.47Vanicoside A
CAS:Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formula:C51H50O21Colore e forma:SolidPeso molecolare:998.93MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formula:C55H66ClN7O9SPurezza:98%Colore e forma:SolidPeso molecolare:1036.67HIF-1 α (556-574)
CAS:HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formula:C101H150D2N20O34S2Purezza:98%Colore e forma:SolidPeso molecolare:2254.6KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Colore e forma:Odour SolidMNN-02-155
CAS:MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).Formula:C56H68ClF2N15O7Colore e forma:SolidPeso molecolare:1136.69PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Colore e forma:Odour SolidMNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Colore e forma:SolidPeso molecolare:486.551CDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Formula:C32H31ClN6O3Purezza:98.30%Colore e forma:SoildPeso molecolare:583.08MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Colore e forma:Odour SolidAxl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormula:C14H19ClO8Purezza:98%Colore e forma:SolidPeso molecolare:350.75PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Purezza:98%Colore e forma:Odour SolidKB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formula:C38H43Cl2N7O6SPurezza:98%Colore e forma:SoildPeso molecolare:796.76SNIPER(BRD)-1
CAS:SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formula:C53H66ClN9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1056.73CBP/p300-IN-8
CAS:<p>CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.</p>Formula:C27H31N3O4Colore e forma:SolidPeso molecolare:461.562JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375PF-04577806
CAS:PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formula:C26H37N7O3Colore e forma:SolidPeso molecolare:495.628XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Colore e forma:Odour SolidMRS2698
CAS:MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.Formula:C9H16N3O13P3SPurezza:98%Colore e forma:SolidPeso molecolare:499.22PROTAC BRD4-DCAF1 degrader-1
CAS:<p>PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.</p>Formula:C60H64Cl2F2N8O9SColore e forma:SolidPeso molecolare:1182.17Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formula:C10H3ClF3NO4Colore e forma:SolidPeso molecolare:293.58HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formula:C43H63F3N6O6S2Colore e forma:SolidPeso molecolare:881.12VinSpinIn
CAS:VinSpinIn is a probe for the Spin family proteins.Formula:C42H58N8O4Colore e forma:SolidPeso molecolare:738.98R 8605
CAS:R 8605 is a third-generation retinoid.Formula:C22H27NO4Colore e forma:SolidPeso molecolare:369.45PROTAC BRD4 Degrader-13
CAS:<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Formula:C68H85F2N11O17P2S2Colore e forma:SolidPeso molecolare:1492.55MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurezza:99.9%Colore e forma:SolidPeso molecolare:321.28HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formula:C20H21N3O3Colore e forma:SolidPeso molecolare:351.399Sirtuin modulator 5
CAS:<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Formula:C24H23N3O4Colore e forma:SolidPeso molecolare:417.46TAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purezza:98%Colore e forma:SolidPeso molecolare:2559.1ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormula:C22H23Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:476.36DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formula:C28H33N5O3Colore e forma:SolidPeso molecolare:487.59PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formula:C27H30F3N7O6S2Purezza:98%Colore e forma:SolidPeso molecolare:669.7BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Colore e forma:SolidPeso molecolare:1152.67PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Colore e forma:SolidPeso molecolare:544.696PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formula:C177H294N62O38S3Purezza:98%Colore e forma:SolidPeso molecolare:3994.84UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formula:C67H104N10O17SColore e forma:SolidPeso molecolare:1353.68Dihydrochlamydocin
CAS:Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.Formula:C28H40N4O6Colore e forma:SolidPeso molecolare:528.65JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidKinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidPROTAC BRD4 Degrader-9
CAS:<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5ZXH-3-26
CAS:<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formula:C38H37ClN8O7SPurezza:98.90% - 98.90%Colore e forma:SolidPeso molecolare:785.27SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formula:C44H64N6O9Purezza:98%Colore e forma:SoildPeso molecolare:821.01HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Formula:C23H40O5Purezza:98%Colore e forma:SolidPeso molecolare:396.56GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formula:C24H32ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:474MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formula:C20H18ClFN6OPurezza:97.02% - >99.99%Colore e forma:SolidPeso molecolare:412.85SR-0813
CAS:<p>SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.</p>Formula:C25H32N6O3SPurezza:98.81%Colore e forma:SolidPeso molecolare:496.62WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formula:C29H31F3N4O4Colore e forma:SolidPeso molecolare:556.576Anemonin (6CI)
CAS:Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Formula:C10H8O4Colore e forma:SolidPeso molecolare:192.17GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColore e forma:SolidPeso molecolare:477.62AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formula:C74H91ClFN11O17S2Colore e forma:SolidPeso molecolare:1525.16GNE-987
CAS:<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Formula:C56H67F2N9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1096.31Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Formula:C15H14O4Colore e forma:SolidPeso molecolare:258.27Antidiabetic agent 7
<p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>Formula:C27H21Cl2N5O3Colore e forma:SolidPeso molecolare:534.39CW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Formula:C45H48N6O8Colore e forma:SolidPeso molecolare:800.9PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formula:C53H64N12O9SPurezza:98%Colore e forma:SolidPeso molecolare:1045.22Lyngbyatoxin A
CAS:<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Formula:C27H39N3O2Colore e forma:SolidPeso molecolare:437.62MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColore e forma:SolidPeso molecolare:1208.5HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purezza:99.59%Colore e forma:SolidPeso molecolare:412.48Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurezza:>99.99% - >99.99%Colore e forma:SoildPeso molecolare:499.75
