Oligosaccaridi

Glycyl-monosialyllacto-N-neohexose I is a monosaccharide that is used as a building block in the synthesis of complex carbohydrates. It is custom synthesized and purified to high purity. This product can be fluorinated and methylated, which allows for the attachment of glycosyl groups. Glycyl-monosialyllacto-N-neohexose I is also a sugar with a CAS number. It has an average molecular weight of 137.14 g/mol and is made up of three atoms: carbon, hydrogen, and oxygen.

NGA2F Glycan is a complex carbohydrate that is synthesized by the enzymatic transfer of an N-acetylgalactosamine (GalNAc) residue to a serine or threonine residue on protein. It is modified with methylation, Click modification, and fluorination. NGA2F Glycan has two binding sites for 2-AB labelled monosaccharides. The glycosylation site is located at the non-reducing end of the molecule, while the oligosaccharide site is located at the reducing end of the molecule.

Lactose is the principal sugar in human and most other mammalian milks, ( 4-O-(β-d-galactopyranosyl)-d-glucopyranose) (Collins, 2006). Lactose undergoes mutarotation; it is a reducing sugar and is significantly less soluble in water than sucrose. Lactose is much less sweet than sucrose (at ~1% about 0.15 (sucrose=1). The enzyme lactase (β-galactosidase), which is present in the small intestine, catalyzes hydrolysis of lactose to form glucose and galactose. Anhydrous lactose is an excipient, filler, diluent, and bulking agent in a wide variety of pharmaceutical tablets, capsules, powders and other preparations. Lactose also has applications as a nutrient and multi-functional ingredient in infant formulae, geriatric, dietetic and health foods (Linko, 1982).

2'-O-Fucosyllactulose is a modified carbohydrate that has been synthesized from a natural source. It is an oligosaccharide that contains the monosaccharide, fucose. This product can be used in the synthesis of polysaccharides and glycosylation reactions. 2'-O-Fucosyllactulose has been methylated, fluorinated, and glycosylated, which makes it suitable for use as a sugar in biotechnology applications.

Hybrid Glycan, 2-AB labelled is a custom synthesis of a high purity glycosylation product. This synthetic oligosaccharide includes saccharides that are labelled with 2-AB. The modification is Click chemistry and provides a method for attaching the label to the sugar molecule. This product is not found in nature or existing in cells or organisms. It is used as a research tool in immunology, cell biology, and structural biology applications.

Dextran 2000 is a high molecular weight biocompatible polymer with transport properties. It is used in a variety of medical applications, such as red blood cell transfusions and the prevention of post-surgical adhesions. Dextran 2000 has been shown to be a safe and effective means of preventing hemolysis during red blood cell transfusion. This agent binds to amine groups on the surface of erythrocytes, which prevents complement activation and subsequent lysis. Additionally, dextran 2000 has been shown to exhibit low cytotoxicity against neuronal cells in vitro.

Cellobiose is a reducing disaccharide consisting of two β(1-4)-linked glucopyranose units. It is produced by the hydrolysis of cellulose, a homopolysaccharide of glucose with β(1-4)-linkages. Cellobiose constitutes the polar part of cellobiose lipids (CLs) that are secreted by yeasts and mycelia fungi. Their various biological activities have led to a range of applications in the food industry, pharmaceutical industry and in medicine. Cellobiose itself has been used as an indicator carbohydrate for Crohn’s disease and malabsorption syndrome. In biotechnology, cellobiose is one of the sugars explored for the synthesis of biotensides.

Minor trisaccharide component of honey

Dextran is a polysaccharide that is used as an antimicrobial agent and as a volume expander in the treatment of bowel disease, myocardial infarct, and other diseases. Dextran sulfate is a linear polymer with a molecular weight of 500,000 to 1,000,000. It has minimal toxicity and does not interfere with iron homeostasis or cause fluid overload. Dextran sulfate can be used for the treatment of bowel disease because it has been shown to have anti-inflammatory effects in experimental models. The mechanism by which dextran sulfate inhibits inflammation is unknown, but may involve its ability to bind to macrophages and neutrophils in the gut wall. Dextran sulfate also binds to bacteria and prevents their growth. This binding may prevent bacterial penetration into epithelial cells or block bacterial attachment to cell surfaces. The efficacy of dextran sulfate against pathogenic mechanisms such as inflammation has been demonstrated in experimental models.

Tridecyl beta-D-maltopyranoside is a synthetic saccharide that has been modified with fluorination and methylation. The carbohydrate can be used in the synthesis of glycosylated proteins. The product is available for custom synthesis, and it is offered in high purity form.

Useful for study of immune response in cancer vaccine development