Angiogénese
Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.
Subcategorias de "Angiogénese"
- BTK(146 produtos)
- Bcr-Abl(102 produtos)
- EGFR(572 produtos)
- FAK(72 produtos)
- FLT(92 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- JAK(245 produtos)
- PDGFR(126 produtos)
- RAAS(87 produtos)
- Src(79 produtos)
- Syk(37 produtos)
- Trombina(47 produtos)
- VDA(2 produtos)
- VEGFR(268 produtos)
Exibir 6 mais subcategorias
Foram encontrados 1431 produtos de "Angiogénese"
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(Z)-Semaxinib
CAS:<p>(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for</p>Fórmula:C15H14N2OPureza:98.82% - ≥95%Cor e Forma:SolidPeso molecular:238.28N-piperidine Ibrutinib
CAS:<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Fórmula:C22H22N6OPureza:96.65%Cor e Forma:SolidPeso molecular:386.45Vorolanib
CAS:<p>Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.</p>Fórmula:C23H26FN5O3Pureza:97.35%Cor e Forma:SolidPeso molecular:439.48Brigatinib
CAS:<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Cor e Forma:SolidPeso molecular:584.09Tivozanib
CAS:<p>Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.</p>Fórmula:C22H19ClN4O5Pureza:98.08% - 99.67%Cor e Forma:SolidPeso molecular:454.86PKI-166 hydrochloride
CAS:<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Fórmula:C20H19ClN4OCor e Forma:SolidPeso molecular:366.85Crizotinib acetate
CAS:<p>Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.</p>Fórmula:C23H26Cl2FN5O3Cor e Forma:SolidPeso molecular:510.39A 83-01
CAS:<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Fórmula:C25H19N5SPureza:97% - 98.2%Cor e Forma:SolidPeso molecular:421.52ZM323881
CAS:<p>ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.</p>Fórmula:C22H18FN3O2Cor e Forma:SolidPeso molecular:375.4ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Fórmula:C20H21N5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:363.41Tropisetron
CAS:<p>Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.</p>Fórmula:C17H20N2O2Pureza:99.68%Cor e Forma:White SolidPeso molecular:284.35ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Fórmula:C23H25NO·HClPureza:98.05%Cor e Forma:SolidPeso molecular:367.91Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Fórmula:C29H32N6O8Cor e Forma:SolidPeso molecular:592.62,4-DPD
CAS:<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Fórmula:C11H13NO4Pureza:99.74%Cor e Forma:Yellow Solid CrystallinePeso molecular:223.23NS309
CAS:<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Fórmula:C8H4Cl2N2O2Pureza:97.55%Cor e Forma:SolidPeso molecular:231.04WHI-P180
CAS:<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Fórmula:C16H15N3O3Pureza:99.21%Cor e Forma:SolidPeso molecular:297.31Bevacizumab
CAS:<p>Ipilimumab targets CTLA-4, an immune checkpoint inhibitor. Bevacizumab binds to VEGF-A isoforms.</p>Pureza:95.40% - CE-SDS:97.5% SEC-HPLC:98.0%Cor e Forma:LiquidPeso molecular:146.53 kDaTolimidone
CAS:<p>Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.</p>Fórmula:C11H10N2O2Pureza:99.85% - 99.85%Cor e Forma:SolidPeso molecular:202.21Arnebin 1
CAS:<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Fórmula:C21H22O6Pureza:98.76% - 99.81%Cor e Forma:SolidPeso molecular:370.396Vadimezan
CAS:<p>Vadimezan (NSC 640488) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity.</p>Fórmula:C17H14O4Pureza:97.38% - 99.8%Cor e Forma:SolidPeso molecular:282.29(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Fórmula:C29H35ClFN7O3Pureza:99.64%Cor e Forma:SolidPeso molecular:584.08Coumarin-3-carboxylic acid
CAS:<p>The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/</p>Fórmula:C10H6O4Pureza:99.88%Cor e Forma:Light Brown Crystalline PowderPeso molecular:190.15Vactosertib Hydrochloride
CAS:<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Fórmula:C22H19ClFN7Pureza:98.03%Cor e Forma:SolidPeso molecular:435.89Saracatinib difumarate
CAS:<p>Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.</p>Fórmula:C35H40ClN5O13Cor e Forma:SolidPeso molecular:774.18AC1NS4RE
CAS:<p>It is a tyrosine kinase inhibitor.</p>Fórmula:C15H13ClN2OPureza:99.53%Cor e Forma:SolidPeso molecular:272.73Verteporfin
CAS:<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Fórmula:C41H42N4O8Pureza:95.37% - 99.82%Cor e Forma:Dark Green To Black SolidPeso molecular:718.79Ibuprofen Lysine
CAS:<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C19H32N2O4Pureza:99.26%Cor e Forma:CoaPeso molecular:352.47Desmethylanethol trithione
CAS:<p>Desmethylanethol trithione (ADT-OH), a synthetic H2S donor, modulates tPA effects, reduces stroke damage, and improves recovery in mice.</p>Fórmula:C9H6OS3Pureza:98.05% - 98.41%Cor e Forma:SolidPeso molecular:226.34FGFR2-IN-3 hydrochloride
CAS:<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Fórmula:C28H25ClFN7O2Cor e Forma:SolidPeso molecular:546.04SC-203
CAS:<p>4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.</p>Fórmula:C33H38N8O4SPureza:96.4% - 99.67%Cor e Forma:SolidPeso molecular:642.77Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Fórmula:C16H14IN3O2Pureza:98.61% - 99.23%Cor e Forma:SolidPeso molecular:407.21PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Fórmula:C11H9N5Pureza:98.61%Cor e Forma:Whit To Off-White SolidPeso molecular:211.22PD-161570
CAS:<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Fórmula:C26H35Cl2N7OPureza:99.92%Cor e Forma:SolidPeso molecular:532.51MELK-8a
CAS:<p>MELK-8a inhibits MELK kinase crucial for cancer cell mitosis (IC50: 2 nM).</p>Fórmula:C25H32N6OCor e Forma:SolidPeso molecular:432.562-(1,8-naphthyridin-2-yl)phenol
CAS:<p>2-NP is a STAT1 enhancer.</p>Fórmula:C14H10N2OPureza:99.33% - 99.82%Cor e Forma:SolidPeso molecular:222.24Silymarin
CAS:<p>Silymarin, a liver-aiding polyphenolic flavonoid, is extracted from milk thistle seeds.</p>Fórmula:C25H22O10Pureza:98%Cor e Forma:Yellow And Brown PowderPeso molecular:482.44Oglufanide
CAS:<p>Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).</p>Fórmula:C16H19N3O5Pureza:99.80%Cor e Forma:SolidPeso molecular:333.34N-Desethylsunitinib hydrochloride
CAS:<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Fórmula:C20H24ClFN4O2Pureza:99.42%Cor e Forma:SolidPeso molecular:406.88SU 4313
CAS:SU 4313 is a bioactive chemical.Fórmula:C18H17NOPureza:99.51% - 99.89%Cor e Forma:SolidPeso molecular:263.33CA-4948
CAS:<p>CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.</p>Fórmula:C24H25N7O5Pureza:99.35% - 99.88%Cor e Forma:SolidPeso molecular:491.5Endoxifen (Z-isomer)
CAS:<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Fórmula:C25H27NO2Pureza:99.19% - 99.81%Cor e Forma:SolidPeso molecular:373.49Nastorazepide
CAS:<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Fórmula:C29H36N4O5Pureza:99.83%Cor e Forma:SolidPeso molecular:520.62Vandetanib hydrochloride
CAS:<p>Vandetanib hydrochloride is an oral VEGFR2 inhibitor with an IC50 of 40 nM, also targeting VEGFR3 (110 nM) and EGFR (500 nM).</p>Fórmula:C22H25BrClFN4O2Cor e Forma:SolidPeso molecular:511.81CGP77675 hydrate
<p>CGP77675 hydrate: Oral Src family kinase inhibitor with IC50s of 5-20/40 nM (Src auto/phosphorylation) and has anticancer properties.</p>Cor e Forma:SolidCZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Fórmula:C17H16FN5Pureza:99.29%Cor e Forma:SolidPeso molecular:309.34VEGFR2-IN-2
CAS:<p>VEGFR2-IN-2 has anti-inflammatory and analgesic activities.</p>Fórmula:C15H11BrN2OPureza:99.504%Cor e Forma:SolidPeso molecular:315.16Afatinib oxalate
CAS:<p>Afatinib oxalate (BIBW 2992) is an irreversible ErbB inhibitor, treating ESCC, NSCLC, and gastric cancer. Targets EGFRwt, EGFRL858R/T790M, HER2.</p>Fórmula:C28H29ClFN5O11Cor e Forma:SolidPeso molecular:666.01Vatalanib succinate
CAS:<p>Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.</p>Fórmula:C24H21ClN4O4Cor e Forma:SolidPeso molecular:464.91(Z)-SU4312
CAS:<p>(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).</p>Fórmula:C17H16N2OPureza:99.17%Cor e Forma:SolidPeso molecular:264.32GMB-475
CAS:<p>GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.</p>Fórmula:C43H46F3N7O7SPureza:98.78% - >99.99%Cor e Forma:SolidPeso molecular:861.93PRT062607 hydrochloride
CAS:<p>PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.</p>Fórmula:C19H23N9O·HClPureza:97.7% - 99.81%Cor e Forma:SolidPeso molecular:429.91Vandetanib trifluoroacetate
CAS:<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Fórmula:C24H25BrF4N4O4Cor e Forma:SolidPeso molecular:589.386KHS 101
CAS:<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Fórmula:C18H21N5SPureza:99.63%Cor e Forma:SolidPeso molecular:339.46Gefitinib-based PROTAC 3
CAS:<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Fórmula:C47H57ClFN7O8SPureza:97.29% - 98.25%Cor e Forma:SolidPeso molecular:934.51Avitinib
CAS:<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Fórmula:C26H26FN7O2Pureza:99.81% - >99.99%Cor e Forma:SolidPeso molecular:487.53Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Fórmula:C29H31Cl2FN4OCor e Forma:SolidPeso molecular:541.49(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Fórmula:C29H32N4O8Cor e Forma:SolidPeso molecular:564.59Cevidoplenib dimesylate hydrochloride
CAS:<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Fórmula:C90H132Cl5N27O12Pureza:97.52%Cor e Forma:SolidPeso molecular:1957.9Ensartinib
CAS:<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Fórmula:C26H27Cl2FN6O3Pureza:99.92%Cor e Forma:SolidPeso molecular:561.44Bafetinib
CAS:<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Cor e Forma:SolidPeso molecular:576.62Pantoprazole sodium
CAS:<p>Pantoprazole sodium is a proton pump inhibitor that irreversibly blocks gastric acid secretion by bonding with H+/K+-ATPase.</p>Fórmula:C16H14F2N3NaO4SPureza:96.92% - 99.81%Cor e Forma:White To Off-White SolidPeso molecular:405.35Tesevatinib
CAS:<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Fórmula:C24H25Cl2FN4O2Pureza:97.89% - 98.66%Cor e Forma:SolidPeso molecular:491.39E-4031 dihydrochloride
CAS:<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Cor e Forma:SolidPeso molecular:474.44ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Fórmula:C28H32FN5O3SPureza:99.84%Cor e Forma:SolidPeso molecular:537.65N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Fórmula:C22H18BrN7Pureza:99.935%Cor e Forma:SolidPeso molecular:460.33Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Fórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:482.82Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Fórmula:C20H19D3N8O3Pureza:98.52% - >99.99%Cor e Forma:SolidPeso molecular:425.46Compound Lup-20(29)-en-3-yl acetate
<p>Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.</p>Fórmula:C32H52O2Pureza:98%Cor e Forma:SolidPeso molecular:468.75Trastuzumab
CAS:<p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>Pureza:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Cor e Forma:LiquidPeso molecular:Approximately 145.53 kDaAG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Fórmula:C16H18N2OPureza:98.12%Cor e Forma:SolidPeso molecular:254.33NVP-BAW2881
CAS:<p>NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.</p>Fórmula:C22H15F3N4O2Pureza:98.19% - 99.97%Cor e Forma:SolidPeso molecular:424.38ASP3026
CAS:<p>ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies,and Positive for Anaplastic Lymphoma Kinase.</p>Fórmula:C29H40N8O3SPureza:98.78% - 99.81%Cor e Forma:SolidPeso molecular:580.747BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.17Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Fórmula:C27H36N6O3SPureza:97.31% - 99.96%Cor e Forma:SolidPeso molecular:524.68UF010
CAS:<p>UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.</p>Fórmula:C11H15BrN2OPureza:98.03% - 99.68%Cor e Forma:SolidPeso molecular:271.15Dasatinib N-oxide
CAS:<p>Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.</p>Fórmula:C22H26ClN7O3SPureza:98.54% - 99.94%Cor e Forma:SolidPeso molecular:504HA 155
CAS:<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Fórmula:C24H19BFNO5SPureza:99.88%Cor e Forma:SolidPeso molecular:463.29WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 99.94%Cor e Forma:SolidPeso molecular:569.58Larotinib mesylate hydrate
CAS:<p>Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM</p>Fórmula:C26H36ClFN4O11S2Cor e Forma:SolidPeso molecular:699.17VH-298
CAS:<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Fórmula:C27H33N5O4SPureza:99.17% - >99.99%Cor e Forma:SolidPeso molecular:523.65Seralutinib
CAS:<p>Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.</p>Fórmula:C27H27N5O3Pureza:99.09%Cor e Forma:SolidPeso molecular:469.54A-176120
CAS:<p>A-176120: potent FPP analog, inhibits farnesyltransferase, anti-angiogenic, may curb H-ras NIH3T3 tumor growth.</p>Fórmula:C33H29NO9Cor e Forma:SolidPeso molecular:583.58Xanthinol Nicotinate
CAS:<p>Xanthinol Nicotinate (Complamin) is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased</p>Fórmula:C13H21N5O4·C6H5NO2Pureza:99.91%Cor e Forma:White Crystalline PowderPeso molecular:434.45EBE-A22
CAS:<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Fórmula:C17H16BrN3O2Pureza:99.087% - 99.88%Cor e Forma:SolidPeso molecular:374.23PF-06651600 malonate
CAS:<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Fórmula:C18H23N5O5Cor e Forma:SolidPeso molecular:389.41ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.53% - 99.7%Cor e Forma:SolidPeso molecular:429.52Canertinib
CAS:<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Fórmula:C24H25ClFN5O3Pureza:98% - >99.99%Cor e Forma:White Or Similar To White Crystalline PowderPeso molecular:485.94Quizartinib HCl
CAS:<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Fórmula:C29H34Cl2N6O4SCor e Forma:SolidPeso molecular:633.59Tandutinib hydrochloride
CAS:<p>Tandutinib hydrochloride: FLT3 inhibitor (IC50 0.22 μM), targets c-Kit, PDGFR, treats AML, crosses blood-brain barrier.</p>Fórmula:C31H43ClN6O4Cor e Forma:SolidPeso molecular:599.16TG 100801
CAS:<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Cor e Forma:SolidPeso molecular:580.08Behenamide
CAS:Produto Controlado<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Fórmula:C22H45NOCor e Forma:White To Off-WhitePeso molecular:339.6Seribantumab
CAS:<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:143.2 (kDa)AZ 5104
CAS:Produto Controlado<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Fórmula:C27H31N7O2Cor e Forma:Off-WhitePeso molecular:485.58Tirabrutinib
CAS:<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Fórmula:C25H22N6O3Pureza:99.64%Cor e Forma:SolidPeso molecular:454.48rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Fórmula:C24H25Cl2N5O2Cor e Forma:NeatPeso molecular:486.39Dapolsertib
CAS:<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Fórmula:C15H18Br2N4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:446.14Cpd27
CAS:<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Fórmula:C20H13F4N5O2Pureza:98.89%Cor e Forma:SolidPeso molecular:431.34Amivantamab
CAS:<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Pureza:97.24% (SEC-HPLC) - 99.74%Cor e Forma:LiquidPeso molecular:145.88 kDaN-Acryloyl Osimertinib (>85%)
CAS:<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Fórmula:C31H35N7O3Pureza:>85%Cor e Forma:Off White SolidPeso molecular:553.65AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Fórmula:C18H18N4O3SPureza:98.23%Cor e Forma:SolidPeso molecular:370.43Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Fórmula:C22H26FN3O3Pureza:99.82% - 99.85%Cor e Forma:SolidPeso molecular:399.458SB 203580 hydrochloride
CAS:<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Fórmula:C21H17ClFN3OSPureza:97.79%Cor e Forma:SolidPeso molecular:413.9SB-505124 hydrochloride
CAS:<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Fórmula:C20H22ClN3O2Pureza:98.71%Cor e Forma:SolidPeso molecular:371.86CCT241161
CAS:<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Fórmula:C28H27N7O3SPureza:99.76% - 99.77%Cor e Forma:SolidPeso molecular:541.62α-Eudesmol
CAS:<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Fórmula:C15H26OCor e Forma:White To Off-WhitePeso molecular:222.37Donafenib
CAS:<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Fórmula:C21H13ClD3F3N4O3Pureza:99.88%Cor e Forma:SolidPeso molecular:467.84rac-Clopidogrel Hydrochloride
CAS:<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Fórmula:C16H16ClNO2S·ClHCor e Forma:NeatPeso molecular:358.28Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Fórmula:C26H28N8OPureza:99.38%Cor e Forma:SolidPeso molecular:468.55Glycerol 1-Monobutyrate (Technical Grade)
CAS:<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Fórmula:C7H14O4Cor e Forma:NeatPeso molecular:162.18Syk Inhibitor II
CAS:<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>Fórmula:C14H15F3N6OPureza:97.63%Cor e Forma:SolidPeso molecular:340.3BIBF 1202
CAS:<p>BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).</p>Fórmula:C30H31N5O4Pureza:98.04%Cor e Forma:SolidPeso molecular:525.6Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Fórmula:C24H27Cl3FN5O3Pureza:99.13% - >99.99%Cor e Forma:SolidPeso molecular:558.86BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Fórmula:C19H24N6O2Pureza:99.08%Cor e Forma:SolidPeso molecular:368.43(5E)-5-(4-Hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS:Produto Controlado<p>Applications 5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue of thiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.<br>References Bhanushali, U., et al.: Bioorg. Chem., 67, 139-147 (2016); Chen, Z., et al.: J. Biol. Chem. 287, 23537 (2012); Fukunaga, T., et al.: J. Bone Miner. Res., 30, 508 (2015)<br></p>Fórmula:C10H7NO3SCor e Forma:NeatPeso molecular:221.23Methyl 6-[[[(2-Chloroethyl)amino]carbonyl]amino]-6-deoxy-α-D-glucopyranoside
CAS:Produto ControladoFórmula:C10H19ClN2O6Cor e Forma:NeatPeso molecular:298.72Solrikitug
CAS:<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Pureza:95%Cor e Forma:LiquidSerclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Pureza:98%Cor e Forma:LiquidVanucizumab
CAS:<p>Vanucizumab is a bispecific humanised monoclonal antibody that simultaneously inhibits the receptor interactions of VEGF-A and Angiopoietin-2 (Ang-2)</p>Pureza:95%Cor e Forma:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Pureza:95%Cor e Forma:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Pureza:95% - 95%Cor e Forma:LiquidDilpacimab
CAS:<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Pureza:95% - 95%Cor e Forma:LiquidAnti-Mouse VEGFR-2 Antibody (DC101)
<p>Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab.</p>Pureza:99%Cor e Forma:Odour LiquidImgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Cor e Forma:LiquidPeso molecular:145.0 (kDa)Tovetumab
CAS:<p>Tovetumab (MEDI-575) is an anti-PDGFRα mAb inhibiting its signaling, in trials for glioblastoma and NSCLC.</p>Pureza:95%Cor e Forma:LiquidIvonescimab
CAS:<p>Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody with cancer immunotherapy and anti-angiogenic effects, NSCLC).</p>Pureza:95% - 95%Cor e Forma:LiquidBafisontamab
CAS:<p>Bafisontamab (EMB-01) is a bispecific antibody that targets EGFR and cMET, displaying antitumor activity [1].</p>Cor e Forma:LiquidIzalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Pureza:95%+ - 95%+Cor e Forma:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Cor e Forma:LiquidFaricimab
CAS:<p>Faricimab,Bispecific antibody targeting Ang-2/VEGF-A. Prevents retinal I/R injury. Improves vision in w-AMD, DME, RVO.</p>Pureza:95% - 95%Cor e Forma:LiquidFidasimtamab
CAS:<p>Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.</p>Pureza:95% - 95%Cor e Forma:LiquidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Pureza:95% - 95%Cor e Forma:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Cor e Forma:LiquidTarcocimab
CAS:<p>Tarcocimab (OG1953) is a humanized IgG1 monoclonal antibody targeting VEGFA, researched for RVO and wet AMD.</p>Cor e Forma:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Pureza:95%Cor e Forma:LiquidDepatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Pureza:95%Cor e Forma:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Cor e Forma:LiquidIbrutinib-d5
CAS:<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Fórmula:C25H24N6O2Pureza:98%Cor e Forma:SolidPeso molecular:445.53Dasatinib-d8
CAS:<p>Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.</p>Fórmula:C22H26ClN7O2SPureza:98%Cor e Forma:SolidPeso molecular:496.06IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Fórmula:C22H17N3O4Cor e Forma:SolidPeso molecular:387.39AD1058
CAS:<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Fórmula:C19H20N6O3SPureza:98.24%Cor e Forma:SolidPeso molecular:412.47EGFR-IN-109
CAS:<p>EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].</p>Fórmula:C12H16N4OSCor e Forma:SolidPeso molecular:264.35HVH-2930
CAS:<p>HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.</p>Fórmula:C29H36N4O3Cor e Forma:SolidPeso molecular:488.62(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37MAPK-IN-2
<p>MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell</p>Fórmula:C20H11Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:380.23Erlotinib mesylate
CAS:<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Fórmula:C23H27N3O7SPureza:98%Cor e Forma:SolidPeso molecular:489.54GZD856 formic
CAS:<p>GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.</p>Fórmula:C30H29F3N6O3Cor e Forma:SolidPeso molecular:578.58ZM39923
CAS:<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Fórmula:C23H25NOPureza:98%Cor e Forma:SolidPeso molecular:331.45ALK5-IN-79
CAS:<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Fórmula:C23H27N7OCor e Forma:SolidPeso molecular:417.51EGFR-IN-117
CAS:<p>EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.</p>Fórmula:C25H30BrN7O2SCor e Forma:SolidPeso molecular:572.52Tyrphostin AG 1478
CAS:Produto Controlado<p>Applications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.<br></p>Fórmula:C16H14ClN3O2Cor e Forma:NeatPeso molecular:315.754-Fmoc-3(R)-morpholinecarboxylic Acid
CAS:Produto Controlado<p>Applications 4-Fmoc-3(R)-morpholinecarboxylic Acid is used to prepare 125I-labeled morpholine-containing RGD ligand of αvβ3 integrin as angiogenesis imaging probe.<br>References Bianchini, F., et al.: J. Med. Chem., 55, 5024 (2012)<br></p>Fórmula:C20H19NO5Cor e Forma:NeatPeso molecular:353.37N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS:Produto ControladoFórmula:C20H16FN5O3Cor e Forma:Light Yellow To YellowPeso molecular:393.372-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
CAS:Produto Controlado<p>Applications 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is an intermediate Apatinib 25-N-Oxide (A726160), a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br></p>Fórmula:C18H16ClN3OCor e Forma:NeatPeso molecular:325.79Tyrphostin AG 112
CAS:Produto Controlado<p>Applications Tyrphostin AG 112 is an EGFR inhibitor.<br></p>Fórmula:C13H8N4OCor e Forma:NeatPeso molecular:236.23Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Produto Controlado<p>Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.<br>References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)<br></p>Fórmula:C24H20ClN5O2Cor e Forma:NeatPeso molecular:445.9LB 42708
CAS:Produto Controlado<p>Applications LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.<br>References Kim, C., et. al.: Mol. Pharmacol., 78, 142 (2010)<br></p>Fórmula:C30H27BrN4O2Cor e Forma:NeatPeso molecular:555.46Pulsatilla Saponin D (90%)
CAS:Produto Controlado<p>Applications Pulsatilla Saponin D shows antiangiogenic and antitumor activity.<br>References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);<br></p>Fórmula:C47H76O17Pureza:90%Cor e Forma:NeatPeso molecular:913.1Dehydrodivanillin (~90%, contains up to 10% unknown inorganics)
CAS:Fórmula:C16H14O6Cor e Forma:NeatPeso molecular:302.279Atrasentan
CAS:Produto Controlado<p>Applications Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.<br>References Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);<br></p>Fórmula:C29H38N2O6Cor e Forma:Off-WhitePeso molecular:510.622,3-Naphthalic Anhydride
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.<br>References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)<br></p>Fórmula:C12H6O3Cor e Forma:NeatPeso molecular:198.17Bucillamine
CAS:<p>Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF.</p>Fórmula:C7H13NO3S2Pureza:99.47%Cor e Forma:SolidPeso molecular:223.31E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46TUL01101
CAS:<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Fórmula:C22H25F2N5O2Cor e Forma:SolidPeso molecular:429.46BGB659
CAS:<p>BGB659 is effective inhibitor of RAF.</p>Fórmula:C29H29F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:538.56KRCA-0713
CAS:<p>KRCA-0713 is a ALK inhibitor.</p>Fórmula:C26H32ClN5O3SPureza:98%Cor e Forma:SolidPeso molecular:530.08EGFR-IN-53
CAS:<p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>Fórmula:C14H13N3O2SCor e Forma:SolidPeso molecular:287.34Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Fórmula:C18H23BrN4O2Cor e Forma:SolidPeso molecular:407.312CAY10717
CAS:<p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>Fórmula:C29H25F3N6O3Cor e Forma:SolidPeso molecular:562.54HP1328
CAS:<p>HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.</p>Fórmula:C23H23N3O3Cor e Forma:SolidPeso molecular:389.45Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07TG53
CAS:<p>TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.</p>Fórmula:C21H22ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:411.88FLT3-IN-17
CAS:<p>FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.</p>Fórmula:C23H24N6O2S2Cor e Forma:SolidPeso molecular:480.61JG26
CAS:<p>JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively,</p>Fórmula:C19H22Br2N4O6SPureza:98.79% - 99.08%Cor e Forma:SolidPeso molecular:594.27GW837016X
CAS:<p>GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation.</p>Fórmula:C25H20ClFN4OSCor e Forma:SolidPeso molecular:478.97YLT192
CAS:<p>YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.</p>Fórmula:C21H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:377.39c-Met-IN-11
CAS:<p>c-Met-IN-11 is a potent inhibitor of c-MET (IC50: 41.4 nM) and VEGFR-2 (IC50: 71.1 nM).</p>Fórmula:C30H20F2N4O3Cor e Forma:SolidPeso molecular:522.5LS-104
CAS:<p>LS-104 is a JAK2 inhibitor.</p>Fórmula:C19H16N2O3Cor e Forma:SolidPeso molecular:320.34FGFR-IN-9
<p>FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).</p>Fórmula:C25H28N6O3SCor e Forma:SolidPeso molecular:492.59AP 24149
CAS:<p>AP 24149, a potent dual inhibitor targeting Src and Abl, exhibits IC50 values of 9.1 nM for Src and 3.6 nM for Abl, respectively.</p>Fórmula:C23H24N5OPCor e Forma:SolidPeso molecular:417.44EGFR-IN-28
CAS:<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Fórmula:C31H39BrN10O3SCor e Forma:SolidPeso molecular:711.68BLK degrader 1
CAS:<p>BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.</p>Fórmula:C32H25F3N6O2Pureza:99.22% - 99.24%Cor e Forma:SolidPeso molecular:582.58LRRK2/NUAK1/TYK2-IN-1
CAS:<p>LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.</p>Fórmula:C20H11F3N6Cor e Forma:SolidPeso molecular:392.34Tyrphostin AG 568
CAS:<p>Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.</p>Fórmula:C13H9N5O2Pureza:98%Cor e Forma:SolidPeso molecular:267.24TL02-59 dihydrochloride
CAS:<p>TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).</p>Fórmula:C32H36Cl2F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:682.56WB-308
CAS:<p>WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.</p>Fórmula:C19H17FN2OPureza:98%Cor e Forma:SolidPeso molecular:308.35VEGFR-2-IN-28
CAS:<p>VEGFR-2-IN-28 is a potent inhibitor of VEGFR-2 (IC50: 0.83 μM). VEGFR-2-IN-28 induces apoptosis and exhibits antitumor effects.</p>Fórmula:C26H17N7O7Cor e Forma:SolidPeso molecular:539.46Momelotinib Mesylate
CAS:<p>Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>Fórmula:C24H26N6O5SPureza:98%Cor e Forma:SolidPeso molecular:510.57ER 27319 maleate
CAS:<p>Selective inhibitor of Syk kinase</p>Fórmula:C22H24N2O5Pureza:98%Cor e Forma:SolidPeso molecular:396.44FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Cor e Forma:SolidPeso molecular:481.93FGFR3-IN-5
CAS:<p>FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.</p>Fórmula:C24H24FN7O3Cor e Forma:SolidPeso molecular:477.49S116836
CAS:<p>S116836 is a tyrosine kinase inhibitor.</p>Fórmula:C27H21F3N6OPureza:98%Cor e Forma:SolidPeso molecular:502.49DS21360717
CAS:<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Fórmula:C21H23N7OPureza:98%Cor e Forma:SolidPeso molecular:389.45Multi-kinase-IN-2
CAS:<p>Orally active Multi-kinase-IN-2 blocks angiokinases including VEGFR, PDGFR, FGFR, and more, reducing AKT/ERK phosphorylation and promoting apoptosis.</p>Fórmula:C34H35N5O3Cor e Forma:SolidPeso molecular:561.67FAK inhibitor 5
CAS:<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Fórmula:C20H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:367.46SB-220025 trihydrochloride
CAS:<p>SB-220025 trihydrochloride is an effective and specific human p38 mitogen-activated protein kinase inhibitor.</p>Fórmula:C18H22Cl3FN6Pureza:98%Cor e Forma:SolidPeso molecular:447.77PDGFRα/FLT3-ITD-IN-2
CAS:<p>PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM).</p>Fórmula:C28H41N9OCor e Forma:SolidPeso molecular:519.68PD173952
CAS:<p>PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.</p>Fórmula:C24H21Cl2N5O2Pureza:99.5%Cor e Forma:SolidPeso molecular:482.36YH-306
CAS:<p>YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.</p>Fórmula:C19H18N2O2Pureza:98.06%Cor e Forma:SolidPeso molecular:306.36
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