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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

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  • Polθ-IN-7
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    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Fórmula:C28H35F3N6O2
    Cor e Forma:Solid
    Peso molecular:544.612

    Ref: TM-T204135

  • Cdc7-IN-10
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    Cdc7-IN-10

    CAS:
    <p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>
    Fórmula:C20H22F2N4O2S
    Cor e Forma:Solid
    Peso molecular:420.48

    Ref: TM-T62230

  • CDK7-IN-33
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    CDK7-IN-33

    CAS:
    <p>CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.</p>
    Fórmula:C29H36N6O4S
    Cor e Forma:Solid
    Peso molecular:564.699

    Ref: TM-T206088

  • DHX9-IN-19
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    DHX9-IN-19

    CAS:
    <p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>
    Fórmula:C20H21ClN4O4S2
    Cor e Forma:Solid
    Peso molecular:480.988

    Ref: TM-T204732

  • Logotipo do CymitQuimica
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    IRE1α kinase-IN-5

    <p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>
    Fórmula:C28H30N6O3S
    Cor e Forma:Solid
    Peso molecular:530.64

    Ref: TM-T63734

  • 3'-Deoxy-GTP
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    3'-Deoxy-GTP

    CAS:
    <p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>
    Fórmula:C10H16N5O13P3
    Cor e Forma:Solid
    Peso molecular:507.181

    Ref: TM-T206927

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    <p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>
    Fórmula:C9H12FN2O9P
    Cor e Forma:Solid
    Peso molecular:342.172

    Ref: TM-T205644

  • Norharmine
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    Norharmine

    CAS:
    <p>Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.</p>
    Fórmula:C12H10N2O
    Cor e Forma:Solid
    Peso molecular:198.221

    Ref: TM-T204194

  • IXA62
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    IXA62

    CAS:
    <p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>
    Fórmula:C24H23N3O3
    Cor e Forma:Solid
    Peso molecular:401.458

    Ref: TM-T206732

  • HNC-1664
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    HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Fórmula:C12H13FIN3O3
    Cor e Forma:Solid
    Peso molecular:393.153

    Ref: TM-T205157

  • Logotipo do CymitQuimica
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    CDK1-IN-4

    <p>CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.</p>
    Fórmula:C26H24ClN5S
    Cor e Forma:Solid
    Peso molecular:474.02

    Ref: TM-T63080

  • Logotipo do CymitQuimica
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    Dyrk1A/α-synuclein-IN-2

    <p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>
    Fórmula:C21H16N4O4S
    Cor e Forma:Solid
    Peso molecular:420.44

    Ref: TM-T62226

  • LNA-GMP
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    LNA-GMP

    CAS:
    <p>LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C11H14N5O8P
    Cor e Forma:Solid
    Peso molecular:375.23

    Ref: TM-TSW-00965

  • CDK2-IN-31
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    CDK2-IN-31

    CAS:
    <p>CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.</p>
    Fórmula:C37H52N6O5
    Cor e Forma:Solid
    Peso molecular:660.85

    Ref: TM-T201156

  • Logotipo do CymitQuimica
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    Anticancer agent 29

    <p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>
    Fórmula:C22H15ClFNO
    Cor e Forma:Solid
    Peso molecular:363.81

    Ref: TM-T61378

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Fórmula:C25H30FN7O
    Cor e Forma:Solid
    Peso molecular:463.55

    Ref: TM-T205073

  • RAD51-IN-6
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    RAD51-IN-6

    CAS:
    <p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>
    Fórmula:C27H40N3O5PS
    Cor e Forma:Solid
    Peso molecular:549.66

    Ref: TM-T63883

  • Glycyl H-1152 hydrochloride
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    Glycyl H-1152 hydrochloride

    CAS:
    <p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>
    Fórmula:C18H26Cl2N4O3S
    Cor e Forma:Solid
    Peso molecular:449.39

    Ref: TM-T35459

  • KI-CDK9d-32
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Fórmula:C39H45N9O4
    Cor e Forma:Solid
    Peso molecular:703.83

    Ref: TM-T207184

  • BBI-355
    Targetmol
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    BBI-355

    CAS:
    <p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>
    Fórmula:C19H19N7O2
    Cor e Forma:Solid
    Peso molecular:377.40

    Ref: TM-T207786