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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3749 produtos de "Ciclo celular/Ponto de verificação"

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  • Logotipo do CymitQuimica
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    3'-O-(4,4'-Dimethoxy trityl)-2'-O-(2-methoxyethyl)-5-methyluridine

    3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine, a purine nucleoside analog, exhibits extensive antitumor properties against indolent
    Fórmula:C34H38N2O9
    Cor e Forma:Solid
    Peso molecular:618.67

    Ref: TM-T75204

  • Logotipo do CymitQuimica
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    3'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine

    3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid
    Fórmula:C38H43N5O9
    Cor e Forma:Solid
    Peso molecular:713.78

    Ref: TM-T75205

  • Logotipo do CymitQuimica
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    PD-1/PD-L1-IN-50

    Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.
    Cor e Forma:Odour Solid

    Ref: TM-T200687

  • Logotipo do CymitQuimica
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    α2β1 Integrin Ligand Peptide TFA

    α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is a
    Fórmula:C16H23F3N4O11
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:504.37

    Ref: TM-TP1374

  • JB300
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    JB300

    CAS:
    JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.
    Fórmula:C43H45ClFN7O10S
    Cor e Forma:Solid
    Peso molecular:906.375

    Ref: TM-T204223

  • Logotipo do CymitQuimica
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    Echistatin TFA

    Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.
    Cor e Forma:Odour Solid

    Ref: TM-T36295

  • 5'-O-TBDMS-dG
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    5'-O-TBDMS-dG

    CAS:
    5’-O-TBDMS-dG is a modified nucleoside. 5’-O-DMT-2’-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    Fórmula:C16H27N5O4Si
    Cor e Forma:Solid
    Peso molecular:381.50

    Ref: TM-T37144

  • 5-Iminodaunorubicin
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    5-Iminodaunorubicin

    CAS:
    5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.
    Fórmula:C27H30N2O9
    Cor e Forma:Solid
    Peso molecular:526.54

    Ref: TM-T72467

  • pNP-ADPr
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    pNP-ADPr

    CAS:
    pNP-ADPr: Used in PARG & ARH3 activity assays; aids in PARP enzyme research.
    Fórmula:C21H26N6O16P2
    Cor e Forma:Solid
    Peso molecular:680.41

    Ref: TM-T41083

  • [pThr3]-CDK5 Substrate
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    [pThr3]-CDK5 Substrate

    CAS:
    [pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].
    Fórmula:C53H100N15O15P
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1218.43

    Ref: TM-TP1602

  • Cdk2/Cyclin Inhibitory Peptide I
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    Cdk2/Cyclin Inhibitory Peptide I

    CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.
    Fórmula:C111H196N48O23
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2571.05

    Ref: TM-TP2192

  • Logotipo do CymitQuimica
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    5'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite

    5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.
    Fórmula:C44H49F2N4O7P
    Cor e Forma:Solid
    Peso molecular:814.85

    Ref: TM-T75190

  • Logotipo do CymitQuimica
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    Brr2-IN-2

    <p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>
    Fórmula:C21H25FN4O2
    Cor e Forma:Solid
    Peso molecular:384.45

    Ref: TM-T205260

  • 5'-O-TBDMS-dA
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    5'-O-TBDMS-dA

    CAS:
    <p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>
    Fórmula:C16H27N5O3Si
    Cor e Forma:Solid
    Peso molecular:365.509

    Ref: TM-T37143

  • Anticancer agent 263
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    Anticancer agent 263

    Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.
    Fórmula:C13H20N2O6
    Cor e Forma:Solid
    Peso molecular:300.308

    Ref: TM-T204102

  • Roccellic Acid
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    Roccellic Acid

    CAS:
    Roccellic acid from R. montagnei lichen has antibacterial, anticancer properties; MIC 46.9 μg/ml; inhibits cancer cells by up to 87.9%.
    Fórmula:C17H32O4
    Cor e Forma:Solid
    Peso molecular:300.43

    Ref: TM-T36409

  • Logotipo do CymitQuimica
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    13-TP

    <p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>
    Fórmula:C12H19F2N6O12P3
    Cor e Forma:Solid
    Peso molecular:570.23

    Ref: TM-T205409

  • WAY-647802
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    WAY-647802

    CAS:
    <p>WAY-647802 is a CDK inhibitor.</p>
    Fórmula:C11H14N4O3
    Pureza:99.53%
    Cor e Forma:Solid
    Peso molecular:250.25

    Ref: TM-T9971

  • Logotipo do CymitQuimica
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    Obtustatin

    <p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>
    Fórmula:C184H284N52O57S8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:4393.07

    Ref: TM-TP1974

  • TMX-2138
    Targetmol
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    TMX-2138

    CAS:
    TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.
    Fórmula:C40H43BrFN9O11S
    Cor e Forma:Solid
    Peso molecular:956.791

    Ref: TM-T204343