NF-κB

DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active …

Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and …

Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high …

Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of …

Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits …

PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 …

Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has …

Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through …

Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that …

GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen …

PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung …

BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 …

CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting …

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase …

SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects …

HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. …

Picein (Piceoside) is derived from Picrorhiza kurroa and shows antioxidant properties.

8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 …

BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM …

Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes …

CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in …

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory …

Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α2 and …

EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 …

Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in …

MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates …

Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects …

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages …

Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of …

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing …

NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of …

Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.

Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of …

Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant …

Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and …

Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and …

Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.

Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT …

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity …

Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 …

GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 …

Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, …

SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 …

Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition …

Schisandrone (Arisantetralone C) is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.

5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a …

Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced …

Selnoflast (example 6) is a NLRP3 inhibitor[1].

Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on …

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity …

CHPG hydrochloride is a selective agonist of mGluR5.

NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced …