Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(49 produtos)
- Cisteína Protease(119 produtos)
- DPP-4(26 produtos)
- Glutaminase(46 produtos)
- HIV Protease(486 produtos)
- PAI-1(29 produtos)
- Inibidores de Protease(49 produtos)
- Receptor activado por protease(57 produtos)
- Proteassoma(91 produtos)
- Protease serina(66 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 922 produtos para "Proteases/Proteassoma".
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Telaprevir
CAS:Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).Fórmula:C36H53N7O6Pureza:96.9% - 98.89%Cor e Forma:White SolidPeso molecular:679.85Ximelagatran
CAS:Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.Fórmula:C24H35N5O5Pureza:95.48% - 99.60%Cor e Forma:SolidPeso molecular:473.57MMP-9-IN-1
CAS:MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).Fórmula:C16H17F2N3O3SPureza:99.21% - 99.91%Cor e Forma:White SolidPeso molecular:369.39Ref: TM-T8310
2mg71,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg167,00€25mg326,00€50mg497,00€100mg708,00€200mg964,00€4-Isopropylcatechol
CAS:4-Isopropylcatechol is a potent depigmenting agent and is of use in the topical therapy of selected patients with hypermelanosis.Fórmula:C9H12O2Pureza:97.93%Cor e Forma:SolidPeso molecular:152.19Ref: TM-T9065
1mg47,00€1mL*10mM (DMSO)84,00€5mg96,00€10mg145,00€25mg235,00€50mg329,00€100mg447,00€200mg600,00€Dabigatran
CAS:Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.Fórmula:C25H25N7O3Pureza:97.44% - 98.7%Cor e Forma:SolidPeso molecular:471.51CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)
CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9.Fórmula:C54H75N13O16S2Pureza:99.97%Cor e Forma:SolidPeso molecular:1226.39Tris(4-aminophenyl)methane
CAS:Tris(4-aminophenyl)methane (Leucopararosaniline), a triphenylmethane dye, is a weak HCV helicase inhibitor.Fórmula:C19H19N3Pureza:96.52%Cor e Forma:SolidPeso molecular:289.37Hepln-13
CAS:Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.Fórmula:C17H13BrN2Pureza:97.67%Cor e Forma:SolidPeso molecular:325.2Ref: TM-T25492
1mg35,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)92,00€10mg119,00€25mg231,00€50mg344,00€100mg480,00€200mg663,00€Grazoprevir
CAS:Grazoprevir (MK-5172) is a protease inhibitor targeting hepatitis C virus NS3/4A used for treating chronic HCV genotypes 1 or 4 infections. Cost-effective and quality-assured.Fórmula:C38H50N6O9SPureza:99.36% - 99.99%Cor e Forma:SolidPeso molecular:766.92-Chloromethyl-1,1-dioxo-1,2-dihydro-1λ*6*-benzo[d]isothiazol-3-one
CAS:2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).Fórmula:C8H6ClNO3SPureza:97.28%Cor e Forma:SolidPeso molecular:231.66Ref: TM-T8602
2mg34,00€5mg48,00€1mL*10mM (DMSO)52,00€10mg63,00€25mg103,00€50mg154,00€100mg224,00€200mg331,00€LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Fórmula:C25H29FN4O5Pureza:97.83% - 99.54%Cor e Forma:White SolidPeso molecular:484.52Ref: TM-TQ0116
1mg90,00€2mg130,00€5mg198,00€1mL*10mM (DMSO)207,00€10mg263,00€25mg462,00€50mg672,00€100mg945,00€KKI-5 acetate(97145-43-2 free base)
KKI-5 acetate: Serine protease inhibitor, targets kallikrein/plasmin, potential anticancer and angioedema therapy.Fórmula:C37H59N11O11Pureza:99.74%Cor e Forma:White SolidPeso molecular:833.95Elbasvir
CAS:Elbasvir (MK-8742) is an NS5A inhibitor developed for chronic HCV treatment.Fórmula:C49H55N9O7Pureza:98.95% - 99.85%Cor e Forma:SolidPeso molecular:882.02Ref: TM-T4544
1mg42,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)111,00€10mg113,00€25mg200,00€50mg334,00€100mg537,00€GW280264X
CAS:GW280264X (Carbamic acid) is an inhibitor of ADAM17 .Fórmula:C28H41N5O6SPureza:99.51%Cor e Forma:SolidPeso molecular:575.72Ref: TM-T8961
1mg156,00€5mg319,00€1mL*10mM (DMSO)404,00€10mg477,00€25mg773,00€50mg1.063,00€100mg1.431,00€Alvelestat
CAS:Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.Fórmula:C25H22F3N5O4SPureza:98% - >99.99%Cor e Forma:White SolidPeso molecular:545.53Ref: TM-T3107
1mg34,00€2mg43,00€5mg56,00€1mL*10mM (DMSO)74,00€10mg84,00€25mg148,00€50mg219,00€100mg349,00€500mg830,00€Batimastat
CAS:Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor.Fórmula:C23H31N3O4S2Pureza:98.15% - 99.5%Cor e Forma:SolidPeso molecular:477.64Glecaprevir
CAS:Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).Fórmula:C38H46F4N6O9SPureza:99.14% - 99.33%Cor e Forma:White SolidPeso molecular:838.87Coblopasvir
CAS:Coblopasvir is a pan-genotypic non-structural protein 5A (NS5A) inhibitor. It can be used to study chronic hepatitis C virus infection.Fórmula:C41H50N8O8Pureza:99.33%Cor e Forma:SolidPeso molecular:782.88Rusalatide acetate (497221-38-2 free base)
CAS:Rusalatide acetate (TP508 amide acetate), a regenerated peptide, alleviates radiation-induced gastrointestinal injury by activating stem cells.Fórmula:C99H151N29O37SPureza:>99.99%Cor e Forma:White SolidPeso molecular:2371.5Ref: TM-TP1024
2mg40,00€5mg66,00€10mg95,00€25mg156,00€1mL*10mM (DMSO)164,00€50mg225,00€100mg320,00€200mg434,00€2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
CAS:2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.Fórmula:C14H7BrClNO2Pureza:97.36%Cor e Forma:SolidPeso molecular:336.57Ombitasvir
CAS:Ombitasvir (ABT-267) inhibits HCV protein NS5A, effective orally, EC50: 0.82-19.3 pM (genotypes 1-5), 366 pM (genotype 6a).Fórmula:C50H67N7O8Pureza:97.27% - 99.56%Cor e Forma:SolidPeso molecular:894.11Ref: TM-T7158
2mg40,00€5mg75,00€10mg105,00€1mL*10mM (DMSO)105,00€25mg215,00€50mg313,00€100mg462,00€500mg973,00€Odanacatib
CAS:Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Fórmula:C25H27F4N3O3SPureza:98.53% - 99.53%Cor e Forma:SolidPeso molecular:525.56CH 5450
CAS:CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heartFórmula:C34H44N4O9Pureza:95.93%Cor e Forma:SolidPeso molecular:652.73Proteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Fórmula:C20H21B2NO5Pureza:99.77%Cor e Forma:SolidPeso molecular:377.01Grazoprevir hydrate
CAS:Grazoprevir: Hepatitis C protease inhibitor effective against various genotypes, including drug-resistant strains.Fórmula:C38H52N6O10SPureza:98%Cor e Forma:SolidPeso molecular:784.927-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a inhibitor of Hepatitis C Virus(HCV).Fórmula:C15H16N4Pureza:99.22%Cor e Forma:White SolidPeso molecular:252.31MUN57694
CAS:MUN57694 is an inhibitor of 26S proteasome.Fórmula:C23H25N3O4Pureza:99%Cor e Forma:White SolidPeso molecular:407.46Ref: TM-T9090
2mg35,00€5mg52,00€1mL*10mM (DMSO)64,00€10mg86,00€25mg145,00€50mg210,00€100mg296,00€200mg414,00€4-Phenoxybenzylamine
CAS:4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .Fórmula:C13H13NOPureza:97.26%Cor e Forma:SolidPeso molecular:199.25Ledipasvir
CAS:Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor.Fórmula:C49H54F2N8O6Pureza:99.96%Cor e Forma:SolidPeso molecular:889Ref: TM-T6200
1mg35,00€2mg50,00€5mg74,00€10mg94,00€1mL*10mM (DMSO)94,00€25mg150,00€50mg244,00€100mg421,00€500mg964,00€Teneligliptin
CAS:Teneligliptin (MP-513), potent DPP-4 inhibitor, IC50 ~1 nM, blocks DPP-4 in human/rat plasma and recombinant forms.Fórmula:C22H30N6OSPureza:99.73%Cor e Forma:SolidPeso molecular:426.58(1S,2R)-Alicapistat
CAS:(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Fórmula:C25H27N3O4Pureza:99.60%Cor e Forma:White SolidPeso molecular:433.5Ref: TM-T60150
1mg64,00€5mg142,00€1mL*10mM (DMSO)167,00€10mg197,00€25mg299,00€50mg400,00€100mg537,00€(R)-Trolox
CAS:(R)-Trolox is a selective tyrosinase inhibitor used in food, cosmetics, and pharmaceutical products.Fórmula:C14H18O4Pureza:99.88%Cor e Forma:SolidPeso molecular:250.29KP-457
CAS:KP-457 is a ADAM17 and a TNFα converting enzyme TACE inhibitor that blocks the production of soluble TNF (sTNF).Fórmula:C21H24N2O7S2Pureza:98.33%Cor e Forma:SolidPeso molecular:480.56Ref: TM-T77778
1mg96,00€5mg205,00€1mL*10mM (DMSO)219,00€10mg334,00€25mg620,00€50mg982,00€100mg1.333,00€PSI
CAS:PSI is a proteasome inhibitor.Fórmula:C32H50N4O8Pureza:97% - 98.33%Cor e Forma:SolidPeso molecular:618.76Danoprevir
CAS:Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).Fórmula:C35H46FN5O9SPureza:98% - 99.80%Cor e Forma:Yellow SolidPeso molecular:731.83KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Fórmula:C21H23N3O6Cor e Forma:SolidPeso molecular:413.42Triton X-45(n=4)
CAS:Triton X-45: nonionic, low HLB surfactant, dispersible in water, high Krafft point, relevant for HCV research.Fórmula:C22H38O5Cor e Forma:SolidPeso molecular:382.53(-)-Gallocatechin Gallate
CAS:Fórmula:C22H18O11Pureza:>95.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:458.38Nelfinavir Mesylate
CAS:Fórmula:C32H45N3O4S·CH4O3SPureza:>97.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:663.89ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Cor e Forma:SolidPeso molecular:401.56S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Fórmula:C33H40N8O6Cor e Forma:SolidPeso molecular:644.72HCV-IN-30
CAS:HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).Fórmula:C36H44N6O4Pureza:99.6%Cor e Forma:White SolidPeso molecular:624.77Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.Fórmula:C20H24ClN5O2Pureza:99.78%Cor e Forma:SolidPeso molecular:401.89Ref: TM-T6015
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg236,00€50mg371,00€100mg522,00€200mg743,00€Carboxypeptidase G2 (CPG2) Inhibitor
CAS:Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) is a new CPG2 Inhibitor with antitumor activity.Fórmula:C13H15NO6SPureza:99.96%Cor e Forma:SolidPeso molecular:313.33THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Fórmula:C12H16N2SPureza:98%Cor e Forma:SolidPeso molecular:220.33ER 27319 maleate
CAS:Selective inhibitor of Syk kinaseFórmula:C22H24N2O5Pureza:98.45%Cor e Forma:Yellow SolidPeso molecular:396.44Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Fórmula:C16H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:327.42Tyrosinase-IN-4
CAS:Tyrosinase-IN-4, a potent inhibitor, has uses in skin-whitening, food preservation, cosmetics, agriculture, and medicine.Fórmula:C15H9ClO3Cor e Forma:SolidPeso molecular:272.68MyoMed 205
CAS:MyoMed-205 is an inhibitor of MuRF1 (muscle ring finger protein 1) activity. It effectively prevents early diaphragm contractile dysfunction and atrophy following 12 hours of unilateral phrenic nerve denervation. By inhibiting MuRF1, MyoMed-205 reduces muscle protein ubiquitination and subsequent proteasome degradation. It also increases the protein levels of phosphorylated Akt (ser473), an essential signaling molecule for muscle growth and maintenance. MyoMed-205 is applicable in the research and treatment of diaphragm dysfunction and atrophy (DIDD) due to early disuse, particularly in clinical situations such as diaphragm paralysis or mechanical ventilation.Fórmula:C26H25N3O5SCor e Forma:SolidPeso molecular:491.56Tanomastat
CAS:Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor.Fórmula:C23H19ClO3SPureza:98%Cor e Forma:SolidPeso molecular:410.91
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