Proteases/Proteassoma

Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Proteases/Proteassoma"

Exibir 3 mais subcategorias

Foram encontrados 1092 produtos de "Proteases/Proteassoma"

Pureza (%)

100

produtos por página.

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AL-611
CAS:
- 1613591-70-0
AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).
Fórmula:C₂₅H₃₃F₂N₆O₈P
Cor e Forma:Solid
Peso molecular:614.544
Ref: TM-T39082
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TP0597850
CAS:
- 2642181-22-2
TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].
Fórmula:C₄₁H₅₇N₉O₁₃S
Cor e Forma:Solid
Peso molecular:916.01
Ref: TM-T74714
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Ac-PAL-AMC
CAS:
- 1431362-79-6
Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
Fórmula:C₂₆H₃₄N₄O₆
Cor e Forma:Solid
Peso molecular:498.57
Ref: TM-T37421
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Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.
Fórmula:C₁₄₄H₂₃₄N₃₆O₄₆S
Pureza:97.84% - 98.16%
Cor e Forma:Solid
Peso molecular:3237.68
Ref: TM-TP2056L
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MMP-3 Inhibitor acetate
MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.
Fórmula:C₂₉H₅₀N₁₀O₁₁S
Pureza:98%
Cor e Forma:Solid
Peso molecular:746.83
Ref: TM-T37048L
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Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).
Fórmula:C₂₅H₃₃N₅O₆
Cor e Forma:Solid
Peso molecular:499.56
Ref: TM-T75647
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Tyrosinase-IN-34
Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.
Fórmula:C₁₉H₁₄BrClN₄O
Cor e Forma:Solid
Peso molecular:429.7
Ref: TM-T89968
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RJS308
RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)
Fórmula:C₆₃H₇₅N₁₃O₁₁S
Cor e Forma:Solid
Peso molecular:1222.42
Ref: TM-T205591
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GCPII-IN-1
CAS:
- 1025796-32-0
GCPII-IN-1, a potent PSMA inhibitor, binds with 44.3 nM affinity.
Fórmula:C₁₂H₂₁N₃O₇
Cor e Forma:Solid
Peso molecular:319.314
Ref: TM-T38420
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Ecallantide TFA
Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of
Cor e Forma:Odour Solid
Ref: TM-T82510
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(Iso)-Fosdevirine
CAS:
- 2869918-45-4
(Iso)-Fosdevirine ( (Iso)-GSK2248761), a reverse transcriptase (NNRTI) inhibitor with anti-HIV activity, is used in the study of neurological diseases.
Fórmula:C₂₀H₁₇ClN₃O₃P
Pureza:99.93%
Cor e Forma:Soild
Peso molecular:413.79
Ref: TM-T31860L
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6,6′-Dihydroxythiobinupharidine
CAS:
- 30343-70-5
6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
Fórmula:C₃₀H₄₂N₂O₄S
Cor e Forma:Solid
Peso molecular:526.73
Ref: TM-T79978
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ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrial
Cor e Forma:Odour Solid
Ref: TM-T80737
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HCVP-IN-1
CAS:
- 877225-09-7
HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
Fórmula:C₃₀H₃₄FN₅O₃
Cor e Forma:Solid
Peso molecular:531.632
Ref: TM-T41002
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:
- 82188-67-8
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
Fórmula:C₄₇H₆₄N₁₄O₁₀
Cor e Forma:Solid
Peso molecular:985.1
Ref: TM-T76347
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Carboxypeptidase C
CAS:
- 9046-67-7
Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.
Cor e Forma:Solid
Ref: TM-T76168
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Alisporivir
CAS:
- 254435-95-5
Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.
Fórmula:C₆₃H₁₁₃N₁₁O₁₂
Pureza:99.95%
Cor e Forma:Solid
Peso molecular:1216.64
Ref: TM-T14180
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Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.
Fórmula:C₁₄₄H₂₃₁F₃N₃₆O₄₆S
Cor e Forma:Solid
Peso molecular:3291.65
Ref: TM-T75794
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RXP470
CAS:
- 891198-31-5
RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).
Fórmula:C₃₅H₃₅BrClN₄O₁₀P
Cor e Forma:Solid
Peso molecular:818
Ref: TM-T28633
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Befovacimab
CAS:
- 2156634-62-5
Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.
Cor e Forma:Liquid
Ref: TM-T76921