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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • ELA-21 (human)
    Targetmol
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    ELA-21 (human)

    CAS:
    <p>Apelin receptor agonist with high affinity for normal/PAH hearts (pKi 9.31/9.46). Blocks cAMP, promotes β-arrestin in vitro. Part of ELA-32.</p>
    Fórmula:C112H184N40O25S3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2587.12

    Ref: TM-TP2096

  • Atrial Natriuretic Peptide (ANP) (1-28), rat
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    Atrial Natriuretic Peptide (ANP) (1-28), rat

    CAS:
    <p>Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.</p>
    Fórmula:C128H205N45O39S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:3062.41

    Ref: TM-TP1221

  • Logotipo do CymitQuimica
    Targetmol
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    5-HT1AR/5-HT6R ligand-1

    <p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>
    Fórmula:C25H29ClN4O2S
    Cor e Forma:Solid
    Peso molecular:485.04

    Ref: TM-T205634

  • Logotipo do CymitQuimica
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    D[LEU4,LYS8]-VP TFA

    <p>D[LEU4,LYS8]-VP TFA: V1b receptor agonist; K_i: 0.16 nM (rat), 0.52 nM (human), 1.38 nM (mouse); weak antidiuretic/vasopressor/oxytocic.</p>
    Fórmula:C49H68F3N11O13S2
    Cor e Forma:Solid
    Peso molecular:1140.25

    Ref: TM-T75826

  • 5-trans Latanoprost (free acid)
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    5-trans Latanoprost (free acid)

    CAS:
    <p>Latanoprost, a prodrug eye drop, turns into active acid inside the body and treats high eye pressure. Its trans isomer also likely reduces eye pressure.</p>
    Fórmula:C23H34O5
    Cor e Forma:Solid
    Peso molecular:390.52

    Ref: TM-T37214

  • 5-methoxy-α-Ethyltryptamine
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    5-methoxy-α-Ethyltryptamine

    CAS:
    <p>5-Methoxy-alpha-ethyltryptamine is a psychoactive substance that can cause various effects. It belongs to the tryptamine chemical class and can be used for various psychoactive and stimulant effects. </p>
    Fórmula:C13H18N2O
    Pureza:98.25%
    Cor e Forma:Solid
    Peso molecular:218.29

    Ref: TM-T9746

  • Spantide acetate
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    Spantide acetate

    <p>Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.</p>
    Fórmula:C77H112N20O15
    Pureza:98.9200%
    Cor e Forma:Solid
    Peso molecular:1557.84

    Ref: TM-T20413L

  • ONO-0300302
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    ONO-0300302

    CAS:
    <p>ONO-0300302: LPA1 antagonist, treats Benign Prostatic Hyperplasia, IC50 = 0.16 nM, reduces IUP in rats and dogs for 12h.</p>
    Fórmula:C29H35NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:477.59

    Ref: TM-T28245

  • Agaridoxin
    Targetmol
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    Agaridoxin

    CAS:
    <p>Agaridoxin is a mushroom metabolite.</p>
    Fórmula:C11H14N2O5
    Cor e Forma:Solid
    Peso molecular:254.242

    Ref: TM-T29709

  • PD 144418 oxalate
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    PD 144418 oxalate

    CAS:
    <p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>
    Fórmula:C20H24N2O5
    Pureza:98.76%
    Cor e Forma:Solid
    Peso molecular:372.42

    Ref: TM-T39211

  • SphK1&2-IN-1
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    SphK1&2-IN-1

    CAS:
    <p>SphK1&amp;2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.</p>
    Fórmula:C14H14N2O3S
    Pureza:99.59%
    Cor e Forma:Solid
    Peso molecular:290.34

    Ref: TM-T9992

  • ELA-11(human)
    Targetmol
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    ELA-11(human)

    CAS:
    <p>Apelin receptor agonist with high affinity (Ki = 14 nM). Blocks cAMP production and promotes β-arrestin activation; derived from ELA-32.</p>
    Fórmula:C58H90N16O13S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1283.57

    Ref: TM-TP1922

  • YFLLRNP
    Targetmol
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    YFLLRNP

    CAS:
    <p>YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.</p>
    Fórmula:C45H67N11O10
    Cor e Forma:Solid
    Peso molecular:922.08

    Ref: TM-T80235

  • CB1R agonist 1
    Targetmol
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    CB1R agonist 1

    <p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>
    Fórmula:C20H18F3N3O3S
    Cor e Forma:Solid
    Peso molecular:437.435

    Ref: TM-T206337

  • Halometasone
    Targetmol
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    Halometasone

    CAS:
    <p>Halometasone: synthetic corticosteroid for psoriasis and eczema treatment.</p>
    Fórmula:C22H27ClF2O5
    Cor e Forma:Solid
    Peso molecular:444.9

    Ref: TM-T36379

  • ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
    Targetmol
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    ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate

    CAS:
    <p>ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.</p>
    Fórmula:C22H18N4O3
    Pureza:99.86%
    Cor e Forma:Solid
    Peso molecular:386.4

    Ref: TM-T9887

  • Logotipo do CymitQuimica
    Targetmol
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    Urocortin II, mouse

    CAS:
    <p>Mouse Urocortin II: Selective CRF2 agonist, Ki 0.66 nM for CRFR2, &gt;100 nM for CRFR1, affects central neural circuits.</p>
    Fórmula:C187H320N56O50
    Cor e Forma:Solid
    Peso molecular:4152.96

    Ref: TM-T76127

  • Icatibant
    Targetmol
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    Icatibant

    CAS:
    <p>Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).</p>
    Fórmula:C59H89N19O13S
    Pureza:98%
    Cor e Forma:White Solid
    Peso molecular:1304.52

    Ref: TM-T15547

  • Logotipo do CymitQuimica
    Targetmol
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    P2Y6R antagonist 1

    <p>P2Y6R antagonist 1 (compound 5ab) is a selective, orally active antagonist of P2Y6R, featuring an IC50 value of 19.6 nM. This compound also exhibits anti-inflammatory properties.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T200515

  • Logotipo do CymitQuimica
    Targetmol
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    Ecnoglutide

    CAS:
    <p>Ecnoglutide (XW003) is a glucagon-like peptide 1 (GLP-1) receptor agonist [1] .</p>
    Fórmula:C194H304N48O61
    Cor e Forma:Solid
    Peso molecular:4284.76

    Ref: TM-T76234