GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Exendin-4 (3-39)
CAS:<p>Exendin-4 (3-39) is a truncated peptide missing first 2 amino acids of Exendin-4, a potent GLP-1r agonist used in diabetes and HPA axis research.</p>Fórmula:C176H272N46O58SCor e Forma:SolidPeso molecular:3992.44K1-70
<p>K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.</p>Cor e Forma:LiquidPeso molecular:145.5kDaCAP-100
<p>CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).</p>Cor e Forma:Odour LiquidTeprotumumab
CAS:<p>Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.</p>Pureza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Cor e Forma:LiquidPeso molecular:145.62 kDaGuanylate cyclase-IN-1
CAS:<p>Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.</p>Fórmula:C20H17FN8OCor e Forma:SolidPeso molecular:404.409ZL-1101
<p>ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.</p>Cor e Forma:Odour LiquidPAMP-12 (unmodified)
CAS:<p>PAMP-12 (unmodified), an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM), induces hypotension by inhibiting catecholamine release from</p>Fórmula:C77H118N24O15Cor e Forma:SolidPeso molecular:1619.91JMV 449
CAS:<p>Potent neurotensin agonist; IC50=0.15 nM, EC50=1.9 nM. Causes hypothermia, neuroprotection, analgesia in mice.</p>Fórmula:C38H66N8O7Pureza:98%Cor e Forma:SolidPeso molecular:746.96SRA880 malonate
CAS:<p>SRA880: non-peptide sst(1) antagonist, low affinity for other sst receptors, binds dopamine D4, boosts SRIF, antidepressant-like effects.</p>Fórmula:C29H36N4O8Pureza:98%Cor e Forma:SolidPeso molecular:568.62Zebrafish Kisspeptin-1
CAS:<p>Zebrafish Kisspeptin-1 is the core sequence of the neuropeptide kisspeptin-1, which plays a crucial role in regulating the release of gonadotropin-releasing hormone (GnRH) and modulating the reproductive system.</p>Fórmula:C58H84N16O15Cor e Forma:SolidPeso molecular:1245.39SR-140603
CAS:<p>SR-140603, the less potent enantiomer of SR 140333, is used as the negative control.</p>Fórmula:C37H45Cl3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:656.12[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
CAS:<p>Potent, selective NPY Y5 receptor agonist; IC50: 0.24 nM (Y5), >500 nM (Y2), 530 nM (Y1), 51 nM (Y4); Ki: 0.1-0.15 nM (Y5); increases food intake in vivo.</p>Fórmula:C183H281N57O54S2Pureza:98%Cor e Forma:SolidPeso molecular:4207.67BA 1 TFA
<p>BA1 TFA agonizes BB receptors; binds BRS3, GRPR, NMBR with IC50s of 6, 0.4, 2.5 nM.</p>Fórmula:C59H77F3N14O13Cor e Forma:SolidPeso molecular:1247.32Dapiglutide
CAS:<p>Dapiglutide (ZP7570) is a long-acting GLP-1R & GLP-2R dual agonist for SBS research.</p>Cor e Forma:SolidAG 045572
CAS:<p>AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is</p>Fórmula:C30H37NO5Pureza:99.96%Cor e Forma:SolidPeso molecular:491.62(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
CAS:<p>V1A receptor antagonist; blocks vasopressin & oxytocin, lowers Ca²⁺ levels (IC50: 5/30 nM); long-acting antivasopressor; anxiolytic in dorsal hippocampus.</p>Fórmula:C52H74N14O12S2Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:1151.38MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.Fórmula:C21H21FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:416.47sGnRH-A
CAS:<p>sGnRH-A, a salmon GnRH analog, boosts growth hormone and induces ovulation for artificial insemination.</p>Fórmula:C64H83N17O12Cor e Forma:SolidPeso molecular:1282.45PG-931
CAS:Selective MC4 agonist with IC50: 0.58 nM (MC4), 55 nM (MC3); revives heart/lung function in shocked rats.Fórmula:C59H85N15O11Pureza:98%Cor e Forma:SolidPeso molecular:1180.41JNJ-5207787
CAS:<p>JNJ-5207787, a blood-brain barrier-crossing Y2 receptor antagonist, is >100x selective against Y1/Y4/Y5 and inhibits human/rat Y2 with pIC50s of 7.0/7.1.</p>Fórmula:C32H38N4O2Pureza:98%Cor e Forma:SolidPeso molecular:510.67Adrenotensin (human)
CAS:<p>Adrenotensin: human 153-185 fragment of Adrenomedullin precursor, a 52-amino acid peptide in CGRP hormone family.</p>Fórmula:C143H224N42O43Cor e Forma:SolidPeso molecular:3219.56Urocortin II, human TFA
<p>hUcn II, a CRF family member, targets CRF2 receptor, has time-linked stress regulation effects, showing mild motor suppression and delayed anxiolytic action.</p>Fórmula:C196H340F3N63O56SPureza:98%Cor e Forma:SolidPeso molecular:4564.3CCR8 agonist 1
<p>CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.</p>Fórmula:C22H29NO3Cor e Forma:SolidPeso molecular:355.47Orforglipron hemicalcium hydrate
CAS:<p>Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes [1].</p>Fórmula:C48H48F2N10O5Ca·H2OCor e Forma:SolidPeso molecular:921.02α-MSH TFA
CAS:<p>α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the</p>Fórmula:C79H110F3N21O21SCor e Forma:SolidPeso molecular:1778.93INCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Fórmula:C29H34F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:577.59Gulgafafusp alfa
CAS:<p>Gulgafafusp alfa is a human IgG2κ monoclonal antibody that selectively binds to the glucagon-like peptide 1 receptor (GLP1R) [1].</p>Cor e Forma:LiquidApadenoson TFA
<p>Apadenoson TFA is a potent adenosine A2A receptor (A2AR) agonist that can be used to improve survival in patients infected with SARS.</p>Fórmula:C25H31F3N6O8Pureza:98.08%Cor e Forma:SoildPeso molecular:600.55Ceruletide Ammonium Salt
<p>Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and</p>Fórmula:C58H77N14O21S2Pureza:98.47% - 98.54%Cor e Forma:SoildPeso molecular:1370.44PD-149164
CAS:<p>PD-149164 is an agonist of the CCK-A receptor.</p>Fórmula:C33H38FN3O5Cor e Forma:SolidPeso molecular:575.67[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
CAS:<p>[Tyr22] CGRP (22-37), rat is a fragment of rat CGRP, targeting its receptor and adenylate cyclase, produced by thyroid and stored in the nervous system.</p>Fórmula:C82H120N20O25Cor e Forma:SolidPeso molecular:1785.95AZP-531
CAS:<p>Azp-531 is a disacylated ghrelin used to improve blood sugar control and weight loss.</p>Fórmula:C40H63N15O13Pureza:98%Cor e Forma:SolidPeso molecular:962.02[Ala2] Endothelin-3, human
CAS:<p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>Fórmula:C120H166N26O32S4Cor e Forma:SolidPeso molecular:2613.02Bz-Dab(nbd)-awfpp-nle-NH2
CAS:<p>Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2 is a fluorescent NK2 antagonist.</p>Fórmula:C56H65N13O11Cor e Forma:SolidPeso molecular:1096.2[Lys4] Sarafotoxin S6c
CAS:<p>[Lys4] Sarafotoxin S6c: potent partial endothelin receptor agonist; causes pig coronary contraction, EC50=1.5 nM.</p>Fórmula:C105H153N27O36S5Cor e Forma:SolidPeso molecular:2529.82Neurokinin A(4-10) TFA
<p>Neurokinin A (4-10) TFA is a tachykinin NK 2 receptor agonist [1] .</p>Fórmula:C36H55F3N8O12SCor e Forma:SolidPeso molecular:880.93P2Y14 antagonist 1
<p>P2Y14 antagonist 1 (compound 45) is a highly selective and orally active P2Y14 receptor antagonist with an IC50 value of 0.70 nM. It demonstrates significant anti-inflammatory effects by effectively reducing pulmonary infiltration of immune cells and inflammatory responses through the inhibition of the NLRP3 signaling pathway. P2Y14 antagonist 1 is suitable for studying acute lung injury.</p>Fórmula:C24H21N3O3Cor e Forma:SolidPeso molecular:399.442Tirzepatide TFA
<p>Tirzepatide TFA, a GIP and GLP-1 agonist, targets type 2 diabetes treatment.</p>Fórmula:C227H349F3N48O70Cor e Forma:SolidPeso molecular:4927.47Poly-D-lysine hydrobromide (MW 150000-300000)
<p>Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.</p>Cor e Forma:Odour SolidTezusomant
CAS:Tezusomant is an antagonist of the growth hormone receptor (growth hormone receptor). It is being investigated for potential use in conditions like acromegaly, which are caused by excessive secretion of growth hormone.Fórmula:C120H171N23O32SCor e Forma:SolidPeso molecular:2479.84PSMA/GRPR ligand 1
<p>PSMA/GRPR ligand 1 (compound 3) is a bispecific ligand with dual targeting capabilities for tumors that express PSMA(+) and GRPR(+).</p>Cor e Forma:Odour Solid[Ala1,3,11,15]-Endothelin
CAS:<p>Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).</p>Fórmula:C109H163N25O32SPureza:98%Cor e Forma:SolidPeso molecular:2368OXA(17-33) TFA
<p>OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).</p>Fórmula:C81H126F3N23O24Cor e Forma:SolidPeso molecular:1863Sibenadet hydrochloride
CAS:<p>Sibenadet, a D2/beta2-agonist, is potential useful for the treatment of symptoms of chronic obstructive pulmonary disease.</p>Fórmula:C22H29ClN2O5S2Cor e Forma:SolidPeso molecular:501.06Somatostatin-28 (1-14)
CAS:<p>Somatostatin-28 (1-14) is a truncated neuropeptide from prosomatostatin cleavage.</p>Fórmula:C61H105N23O21SPureza:98%Cor e Forma:SolidPeso molecular:1528.71Adenosine 3'-monophosphate (sodium salt hydrate)
<p>Adenosine 3'-monophosphate (sodium salt hydrate) (3'-AMP) is a nucleotide and cAMP-generating agonist that elevates cAMP levels in NG108-15 cells.</p>Fórmula:C10H15N5NaO8PCor e Forma:SolidPeso molecular:387.22BAM(8-22)
CAS:<p>Potent MRGPRX1 agonist peptide; first found in bovine adrenal glands. Non-opioid, lacking met-enkephalin motif. EC50: 8-150 nM.</p>Fórmula:C91H127N25O23SPureza:98%Cor e Forma:SolidPeso molecular:1971.22Spantide I TFA
<p>Spantide I TFA is a selective NK1 antagonist (230 nM); much less for NK2 (8150 nM); it modulates cytokines to prevent corneal perforation.</p>Fórmula:C77H109F3N20O15Cor e Forma:SolidPeso molecular:1611.81Parstatin(human) TFA
<p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>Fórmula:C193H331F3N64O55S3Cor e Forma:SolidPeso molecular:4581.28Levocarnitine propionate hydrochloride
CAS:<p>Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.</p>Fórmula:C10H20ClNO4Pureza:90% - 99.77%Cor e Forma:SolidPeso molecular:253.72
![[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1963.webp&w=3840&q=75)
![[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT76363.webp&w=3840&q=75)
![[Ala2] Endothelin-3, human](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT76305.webp&w=3840&q=75)
![[Lys4] Sarafotoxin S6c](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT76302.webp&w=3840&q=75)
![[Ala1,3,11,15]-Endothelin](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP2099.webp&w=3840&q=75)
