GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
TRV045
CAS:<p>TRV045 is a selective agonist of the sphingosine-1-phosphate (S1P) subtype 1 receptor and does not impact lymphocyte trafficking. It possesses antiepileptic properties.</p>Fórmula:C18H18N4O3Cor e Forma:SolidPeso molecular:338.36(±)14(15)-EpETE
CAS:<p>(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45Piperulin A
CAS:<p>Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,</p>Fórmula:C23H28O6Cor e Forma:SolidPeso molecular:400.465-HT7R antagonist 1 free base
CAS:<p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>Fórmula:C14H17ClN4Cor e Forma:SolidPeso molecular:276.77(S)-V-0219 hydrochloride
<p>(S)-V-0219 hydrochloride, a GLP-1R PAM, triggers calcium in hGLP-1R HEK cells, lowers glucose in mice, and reduces fasting hunger.</p>Fórmula:C20H26ClF3N4O2Cor e Forma:SolidPeso molecular:446.89GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Cor e Forma:Odour SolidALEPH hydrochloride
CAS:<p>ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.</p>Fórmula:C12H20ClNO2SCor e Forma:SolidPeso molecular:277.81Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Fórmula:C152H243N47O44S4Pureza:98%Cor e Forma:SolidPeso molecular:3561.1Synephrine hemitartrate
CAS:<p>Synephrine hemitartrate, an alkaloid from Citrus aurantium, is a sympathomimetic for weight loss, with α and β-adrenergic action.</p>Fórmula:C9H13NO2C4H6O6Cor e Forma:SolidPeso molecular:242.26Minaprine
CAS:<p>Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.</p>Fórmula:C17H22N4OPureza:98%Cor e Forma:SolidPeso molecular:298.38Antipsychotic agent-2
<p>Compound 11: potent antipsychotic, binds 5-HT1A/2A/2C, D2, H1 receptors; K is 56.6-1140 nM, BBB permeable.</p>Fórmula:C22H26FN5OCor e Forma:SolidPeso molecular:395.47(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)
CAS:<p>(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14), a bombesin (BBN) antagonist, holds potential for cancer research applications [1].</p>Fórmula:C49H69N13O9Cor e Forma:SolidPeso molecular:984.15Sauvagine
CAS:CRF receptor agonist; Ki: 9.4 nM (hCRF-R1), 9.9 nM (rCRF-R2a), 3.8 nM (mCRF-R2b) for 125I-[D-Tyr1]astressin binding inhibition.Fórmula:C202H346N56O63SPureza:98%Cor e Forma:SolidPeso molecular:4599.35Peptide YY (pig)
CAS:<p>Peptide YY (pig), a 36 amino acid gut peptide from porcine duodenum, reduces appetite via Y2 receptor, affecting digestion and the heart.</p>Fórmula:C190H288N54O57Cor e Forma:SolidPeso molecular:4240.72GLP-1 (9-36) amide
CAS:<p>GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor.</p>Fórmula:C140H214N36O43Pureza:97%Cor e Forma:SolidPeso molecular:3089.41Ethylpropyltryptamine
CAS:<p>Ethylpropyltryptamine (EPT) is an orally active novel psychoactive substance. It is predicted to act as a partial agonist of the 5-HT2A receptor.</p>Fórmula:C15H22N2Cor e Forma:SolidPeso molecular:230.35PSMA/GRPR ligand 1
<p>PSMA/GRPR ligand 1 (compound 3) is a bispecific ligand with dual targeting capabilities for tumors that express PSMA(+) and GRPR(+).</p>Cor e Forma:Odour SolidRoxatidine
CAS:<p>Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.</p>Fórmula:C17H26N2O3Cor e Forma:SolidPeso molecular:306.4UCM 549
CAS:<p>UCM 549 is a bioactive chemical.</p>Fórmula:C19H21NO2Cor e Forma:SolidPeso molecular:295.38Neuropeptide Y (22-36)
CAS:<p>Neuropeptide Y (22-36) is a 15-amino acid fragment of NPY, which is abundant in the mammalian brain and involved in multiple physiological functions.</p>Fórmula:C85H139N29O21Pureza:98%Cor e Forma:SolidPeso molecular:1903.19MM 07
CAS:<p>Biased agonist for apelin/G protein pathway, enhances eNOS and cell growth, reduces apoptosis, improves heart function, and dilates vessels.</p>Fórmula:C67H106N22O14S3Pureza:98%Cor e Forma:SolidPeso molecular:1539.9Adrenocorticotropic Hormone (ACTH) (4-10), human
CAS:<p>Adrenocorticotropic Hormone (ACTH) (4-10) is an agonist of potent melanocortin(MC4R) receptor .</p>Fórmula:C44H59N13O10SPureza:98%Cor e Forma:SolidPeso molecular:962.09Tienoxolol FA
<p>Tienoxolol FA, a beta-blocker for treating heart disease, hypertension, and ischemia.</p>Fórmula:C22H30N2O7SPureza:97.05% - 98.85%Cor e Forma:SoildPeso molecular:466.55FSLLRY-NH2
CAS:<p>PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.</p>Fórmula:C39H60N10O8Pureza:98%Cor e Forma:SolidPeso molecular:796.97Terazosin dimer impurity dihydrochloride
CAS:<p>Terazosin dimer impurity dihydrochloride is a chemical byproduct of the α1-antagonist Terazosin, derived from quinazoline.</p>Fórmula:C24H30Cl2N8O4Cor e Forma:SolidPeso molecular:565.46ACTH (1-17)
CAS:<p>ACTH (1-17), a potent MC1 receptor agonist with a Ki of 0.21 nM, is a variant of corticotropin from the pituitary gland.</p>Fórmula:C95H145N29O23SPureza:98%Cor e Forma:SolidPeso molecular:2093.41β-CGRP (mouse)
<p>β-CGRP (mouse), a calcitonin gene-related peptide, induces vasodilation and is applicable in research areas including cardiovascular, pro-inflammatory, migraine, and metabolic studies.</p>Fórmula:C165H265N49O55S2Cor e Forma:SolidPeso molecular:3879.29PACAP (1-38) free acid TFA
<p>PACAP (1-38) free acid TFA, an endogenous neuropeptide, effectively enhances antral motility and somatostatin secretion, while concurrently suppressing gastrin</p>Cor e Forma:Odour SolidProtease-Activated Receptor-1 antagonist 2
CAS:<p>Orally active PAR-1 antagonist with 7 nM IC50; potential for CVD research.</p>Fórmula:C24H23F2N3O2Cor e Forma:SolidPeso molecular:423.46Tocrifluor T1117
CAS:<p>Fluorescent form of AM 251, CB1 receptor antagonist</p>Fórmula:C56H53Cl2N7O5Pureza:98%Cor e Forma:SolidPeso molecular:974.97Cortistatin-8 acetate
<p>Cortistatin-8 acetate: synthetic corticosteroid analog, GHS-R antagonist; doesn't affect acyl GH release or hesperidin response.</p>Fórmula:C49H72N12O11S2Pureza:99.01%Cor e Forma:SoildPeso molecular:1069.3FR167344 free base
CAS:<p>FR167344 free base: oral, nonpeptide B2 bradykinin receptor antagonist, high-affinity (IC50: 65 nM), no B1 affinity.</p>Fórmula:C30H28BrCl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:673.38MK-0493 HCl
CAS:<p>MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R).</p>Fórmula:C30H39Cl2F2N3O2Cor e Forma:SolidPeso molecular:582.5515(S)-15-methyl Prostaglandin F2α methyl ester
CAS:<p>15(S)-15-methyl Prostaglandin F2α methyl ester can be used in related research in the field of life sciences.</p>Fórmula:C22H38O5Cor e Forma:SolidPeso molecular:382.53BMS-193885
CAS:<p>BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.</p>Fórmula:C33H42N4O6Pureza:99.73%Cor e Forma:SolidPeso molecular:590.71INCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Fórmula:C29H34F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:577.59Spantide acetate
<p>Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.</p>Fórmula:C77H112N20O15Pureza:98.9200%Cor e Forma:SolidPeso molecular:1557.84Samelisant
CAS:<p>Samelisant (SUVN-G3031), a selective H3 inverse agonist, Ki=8.7/9.8 nM in humans/rats, has anti-narcoleptic properties.</p>Fórmula:C21H31N3O3Pureza:99.59%Cor e Forma:SolidPeso molecular:373.49rac Desmethyl Citalopram Hydrochloride
CAS:<p>rac Desmethyl Citalopram Hydrochloride is a 5-hydroxy tryptamine uptake inhibitor with IC50 value of 0.013 μM.</p>Fórmula:C19H20ClFN2OPureza:99.24%Cor e Forma:SolidPeso molecular:346.8311-deoxy Prostaglandin E2
CAS:<p>11-deoxy PGE2 is a synthetic PGE2 analog, a potent bronchoconstrictor, 5-30x stronger than PGF2α on human respiratory muscles.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47AC-264613
CAS:<p>AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.</p>Fórmula:C19H18BrN3O2Pureza:98%Cor e Forma:SolidPeso molecular:400.28Amylin (IAPP), feline
<p>Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.</p>Fórmula:C165H270N52O54S2Pureza:98%Cor e Forma:SolidPeso molecular:3910.45EP4 receptor antagonist 3
CAS:<p>EP4 receptor antagonist 3 from patent WO2010019796 A1 targets EP4 for research on pain, arthritis, and cancer.</p>Fórmula:C26H21F3N2O3SCor e Forma:SolidPeso molecular:498.52Norisoboldine hydrochloride
CAS:<p>Norisoboldine hydrochloride: an oral AhR agonist from Radix Linderae, for Rheumatoid arthritis and Ulcerative colitis research.</p>Fórmula:C18H20ClNO4Cor e Forma:SolidPeso molecular:349.81VVZ-149
<p>VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.</p>Cor e Forma:SolidIlatreotide
CAS:<p>Ilatreotide is a Amadori compound of octreotide.</p>Fórmula:C61H86N10O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1343.53RWJ 676070
CAS:<p>RWJ 676070 is an antagonist of vasopressin V1A/V2 receptor.</p>Fórmula:C30H26ClFN2O5Cor e Forma:SolidPeso molecular:548.99Drinabant
CAS:<p>Drinabant (AVE-1625) is an orally active CB1 receptor antagonist.</p>Fórmula:C23H20Cl2F2N2O2SPureza:99.8%Cor e Forma:SolidPeso molecular:497.38GB-6
CAS:<p>GB-6, a short linear peptide that selectively binds to the gastrin releasing peptide receptor (GRPR), shows potential as a high-contrast imaging probe due to</p>Fórmula:C32H45N11O8Pureza:98%Cor e Forma:SolidPeso molecular:711.77EB1002
CAS:<p>EB1002 is a selective NK2R agonist that has demonstrated significant enhancements in the expression levels of genes associated with mitochondrial biogenesis (such as PGC-1α) in obese mice. This suggests that EB1002 promotes energy expenditure by enhancing mitochondrial activity. Additionally, EB1002 has improved insulin sensitivity and glucose-lipid metabolism in mice. Therefore, EB1002 holds potential for research into obesity and type 2 diabetes.</p>Fórmula:C73H124N12O23Cor e Forma:SolidPeso molecular:1537.83
