GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Kisspeptin 234
CAS:<p>Kisspeptin receptor antagonist; blocks kisspeptin-10 effects on IP (IC50 = 7 nM) and GnRH release.</p>Fórmula:C63H78N18O13Pureza:98%Cor e Forma:SolidPeso molecular:1295.42Sauvagine TFA
<p>Sauvagine TFA: frog-derived, 40-amino-acid CRF agonist; stimulates ACTH release, affects diuresis, cardiovascular system, endocrine glands.</p>Fórmula:C204H347F3N56O65S1Cor e Forma:SolidPeso molecular:4713.33Cortistatin-29 (rat) (trifluoroacetate salt)
CAS:<p>Cortistatin-29, similar to somatostatin-28, derives from preprocortistatin and binds to SST receptors 1-5 with varying IC50 values.</p>Fórmula:C161H240N46O41S2Cor e Forma:SolidPeso molecular:3540.09LY-53857 free base
CAS:<p>LY-53857 free base is a bioactive chemical.</p>Fórmula:C23H32N2O3Cor e Forma:SolidPeso molecular:384.51Galantide
CAS:<p>Galantide is a reversible and non-specific antagonist of galanin receptor.</p>Fórmula:C104H151N25O26SPureza:98%Cor e Forma:White Lyophilised SolidPeso molecular:2199.53HAEGTFTSDVS acetate
<p>HAEGTFTSDVS acetate is the first N-terminal 1-11 residues of GLP-1 which stimulates insulin secretion from pancreatic β-cells.</p>Fórmula:C50H75N13O22Pureza:97.47%Cor e Forma:SolidPeso molecular:1210.2Brexpiprazole S-oxide
CAS:<p>Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).</p>Fórmula:C25H27N3O3SPureza:98%Cor e Forma:SolidPeso molecular:449.57JNJ-10181457 (hydrochloride)
CAS:<p>JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations</p>Fórmula:C20H30Cl2N2OCor e Forma:SolidPeso molecular:385.37K-(D-1-Nal)-FwLL-NH2 TFA
<p>K-(D-1-Nal)-FwLL-NH2 TFA: potent ghrelin inverse agonist; Ki=4.9 nM (COS7), 31 nM (HEK293T); blocks Gq/G13 signaling.</p>Fórmula:C53H68F3N9O8Cor e Forma:SolidPeso molecular:1016.16Lobeline sulfate
CAS:<p>Lobeline sulfate, an alkaloid like nicotine, aids in smoking cessation, insomnia, and respiratory issues. Less potent on nicotinic receptors.</p>Fórmula:C22H29NO6SPureza:98%Cor e Forma:White PowderPeso molecular:435.54Pexopiprant
CAS:<p>Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.</p>Fórmula:C21H17Cl2F2NO4Cor e Forma:SolidPeso molecular:456.27NSC380324
<p>NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.</p>Fórmula:C31H24N4O4Cor e Forma:SolidPeso molecular:516.55(±)5(6)-EET
CAS:<p>5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.473SR142948A
CAS:<p>SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.</p>Fórmula:C39H52ClN5O6Pureza:98%Cor e Forma:SolidPeso molecular:722.31Tiaprost
CAS:<p>Tiaprost is a analog of prostaglandin F2α .</p>Fórmula:C20H28O6SPureza:98%Cor e Forma:SolidPeso molecular:396.55-HT1AR/5-HT6R ligand-1
<p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>Fórmula:C25H29ClN4O2SCor e Forma:SolidPeso molecular:485.04(-)-Eseroline fumarate
CAS:<p>(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.</p>Fórmula:C17H22N2O5Cor e Forma:SolidPeso molecular:334.37BMS-604992 dihydrochloride
CAS:<p>BMS-604992 dihydrochloride is a selective GHSR agonist with high affinity (Ki=2.3 nM) and potent activity (EC50=0.4 nM), stimulating rodent appetite.</p>Fórmula:C24H33Cl2N7O5Cor e Forma:SolidPeso molecular:570.47Etelcalcetide
CAS:<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Fórmula:C38H73N21O10S2Pureza:98%Cor e Forma:SolidPeso molecular:1048.26d[Cha4]-AVP TFA
<p>d[Cha4]-AVP TFA: potent, selective V1b agonist, K i 1.2 nM, favors V1b over V1a, V2, oxytocin receptors.</p>Fórmula:C52H72F3N13O13S2Cor e Forma:SolidPeso molecular:1208.33TRPV1/CB2 agonist 1
<p>TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.</p>Cor e Forma:Odour SolidP2Y14R antagonist 3
<p>P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases.</p>Fórmula:C26H25N5O5Cor e Forma:SolidPeso molecular:487.51Luseogliflozin hydrate
CAS:<p>Luseogliflozin hydrate: SGLT2 inhibitor, IC50 2.26 nM, oral, for type 2 diabetes research.</p>Fórmula:C23H32O7SCor e Forma:SolidPeso molecular:452.56LE 300
CAS:<p>LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.</p>Fórmula:C20H22N2Pureza:97.91% - 98.79%Cor e Forma:SolidPeso molecular:290.44-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS:<p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>Fórmula:C27H28ClFN2OSPureza:99.02%Cor e Forma:SoildPeso molecular:483.04MrgprX2 antagonist-3
CAS:<p>MrgprX2 antagonist-3 (compound E117) is a MrgprX2 antagonist applicable for investigating cutaneous inflammation.</p>Fórmula:C16H20FN3O2SPureza:98.06%Cor e Forma:SolidPeso molecular:337.41Orexin B, rat, mouse TFA
<p>Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.</p>Fórmula:C128H216F3N45O36SCor e Forma:SolidPeso molecular:3050.42Cloprostenol isopropyl ester
CAS:<p>(+)-Chloprostol is a PGF2α agonist, mimics prostaglandin F2α, induces luteal dissolution in mares without side effects or stress.</p>Fórmula:C25H35ClO6Cor e Forma:SolidPeso molecular:466.99G-Protein antagonist peptide
CAS:<p>Peptide inhibits G protein-receptor binding; competitively blocks M2 and β-adrenoceptor-induced Gs/Gi/Go activation.</p>Fórmula:C57H64N12O9SPureza:98%Cor e Forma:SolidPeso molecular:1093.27Piperulin A
CAS:<p>Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,</p>Fórmula:C23H28O6Cor e Forma:SolidPeso molecular:400.46Phenylethanolamine A
CAS:<p>Phenylethanolamine A is a β-adrenergic agonist and a byproduct of the Ractopamine synthesis process.</p>Fórmula:C19H24N2O4Cor e Forma:SolidPeso molecular:344.40CCK Octapeptide, non-sulfated acetate
<p>CCK Octapeptide, non-sulfated acetate is a synthetic desulfated peptide of cholecystokinin.</p>Fórmula:C51H66N10O15S2Pureza:98.9700%Cor e Forma:SolidPeso molecular:1123.26[D-Phe12,Leu14]-Bombesin
CAS:<p>Bombesin receptor blocker; stops binding in rat brain (IC50=2 μM), hinders amylase release (IC50=4 μM), reduces appetite suppression in vivo.</p>Fórmula:C77H113F3N22O20Pureza:98%Cor e Forma:SolidPeso molecular:1724.9CGRP antagonist 6
<p>CGRP Antagonist 6 (Compound 23) is a potent CGRP receptor antagonist (Ki: 0.84 nM). It is utilized in the study of migraines.</p>Cor e Forma:Odour Solid[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
CAS:<p>Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.</p>Fórmula:C79H109N19O12Pureza:98%Cor e Forma:SolidPeso molecular:1516.85AR-C126313
CAS:<p>AR-C126313 is a thiouracil derivative.</p>Fórmula:C28H23N7O3SCor e Forma:SolidPeso molecular:537.59Serazapine
CAS:<p>Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders.</p>Fórmula:C22H23N3O2Pureza:98.71% - 99.57%Cor e Forma:SolidPeso molecular:361.44GLP-2(1-33)(human)
CAS:GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.Fórmula:C165H254N44O55SPureza:98%Cor e Forma:SolidPeso molecular:3766.19GLP-1R agonist 27
<p>GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. It enhances the accumulation of cyclic adenosine monophosphate (cAMP), reduces blood glucose levels, and decreases food intake. GLP-1R agonist 27 shows potential for research in obesity and type 2 diabetes mellitus (T2DM).</p>Fórmula:C32H33N5O4SeCor e Forma:SolidPeso molecular:630.6Orforglipron hemicalcium hydrate
CAS:<p>Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes [1].</p>Fórmula:C48H48F2N10O5Ca·H2OCor e Forma:SolidPeso molecular:921.02Kassinin
CAS:<p>Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.</p>Fórmula:C59H95N15O18SPureza:98%Cor e Forma:SolidPeso molecular:1334.54Pasireotide
CAS:<p>Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).</p>Fórmula:C58H66N10O9Pureza:98%Cor e Forma:SolidPeso molecular:1047.21Cortagine
<p>Potent CRF1 agonist, EC50 = 0.18 nM in rats. Exhibits in vivo anxiolytic and antidepressant effects; reduces mouse defensive behavior.</p>Fórmula:C192H323N55O63SPureza:98%Cor e Forma:SolidPeso molecular:4442.06Hemopressin (human, mouse)
CAS:<p>Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.</p>Fórmula:C50H79N13O12Pureza:98%Cor e Forma:SolidPeso molecular:1054.269-deoxy-9-methylene Prostaglandin E2
CAS:<p>9-deoxy-9-methylene PGE2: stable PGE2 analog with similar effects, less side effects, equal potency in rats, gerbils, primates.</p>Fórmula:C21H34O4Cor e Forma:SolidPeso molecular:350.499(+)-Oxypeucedanin methanolate
CAS:<p>(+)-Oxypeucedanin methanolate (compound 9) is a natural compound that inhibits prostaglandin E2 production [1].</p>Fórmula:C17H18O6Cor e Forma:SolidPeso molecular:318.32DOTA-LM3 TFA
<p>DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2.</p>Fórmula:C71H94ClF3N16O21S2Cor e Forma:SolidPeso molecular:1664.18HAEGT
CAS:<p>HAEGT is the first N-terminal 1-5 residues of GLP-1 peptide.</p>Fórmula:C20H31N7O9Pureza:98%Cor e Forma:SolidPeso molecular:513.5Triazolomethylindole-3-acetic acid
CAS:<p>Triazolomethylindole-3-acetic acid is a metabolite of Rizatriptan, which acts as an agonist for the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.</p>Fórmula:C13H12N4O2Cor e Forma:SolidPeso molecular:256.26Pancreatic Polypeptide, human
CAS:<p>Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract.</p>Fórmula:C185H287N53O54S2Pureza:98%Cor e Forma:SolidPeso molecular:4181.71
![4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-me…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT60126.webp&w=3840&q=75)
![[D-Phe12,Leu14]-Bombesin](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1916.webp&w=3840&q=75)
![[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1931.webp&w=3840&q=75)
