GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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GFB-024
<p>GFB-024 is a humanized antibody targeting CB1, which can be used to study obesity.</p>Cor e Forma:LiquidPeso molecular:145.5kDaDexchlorpheniramine free base
CAS:<p>Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.</p>Fórmula:C16H19ClN2Pureza:98%Cor e Forma:Oily Liquid SolidPeso molecular:274.791-(4-Fluorobenzyl)-1H-indazole-3-carboxylic acid
CAS:<p>1-(4-Fluorobenzyl)-1H-indazole-3-carboxylic acid (Compound 31) is a metabolite of AB-FUBINACA. It acts as an MRGPRX4 antagonist with an IC50 greater than 2.5 μM.</p>Fórmula:C15H11FN2O2Cor e Forma:SolidPeso molecular:270.26Antibiotic Sch 60057
CAS:<p>Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.</p>Fórmula:C45H84O6Cor e Forma:SolidPeso molecular:721.161Antisauvagine-30 TFA
<p>aSvg-30 TFA: potent CRF2 receptor antagonist, Kd 1.4 nM (mCRFR2β), 150 nM (CRFR1).</p>Fórmula:C163H275N48F3O49SCor e Forma:SolidPeso molecular:3764.284-Hydroxy MET
CAS:<p>4-Hydroxy MET (4-HO-MET) is a tryptamine-based new psychoactive substance (NPS), structurally similar to the endogenous neurotransmitter serotonin. It has hallucinogenic properties that affect mood, movement, and cognitive functions.</p>Fórmula:C13H18N2OCor e Forma:SolidPeso molecular:218.3Prosaptide TX14(A)
CAS:<p>GPR37L1/GPR37 agonist with EC50 of 5/7 nM, activates G proteins, enhances ERK, myelin synthesis, neuro/glioprotection.</p>Fórmula:C69H110N16O26Pureza:98%Cor e Forma:SolidPeso molecular:1579.72FR 113680
CAS:<p>FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.</p>Fórmula:C35H39N5O6Pureza:98%Cor e Forma:SolidPeso molecular:625.726Angiopeptin
CAS:<p>Angiopeptin is a synthetic octapeptide analog of somatostatin; suppresses accelerated transplant atherosclerosis in rabbit heart arteries.</p>Fórmula:C54H71N11O10S2Cor e Forma:SolidPeso molecular:1098.34Sauvagine
CAS:<p>CRF receptor agonist; Ki: 9.4 nM (hCRF-R1), 9.9 nM (rCRF-R2a), 3.8 nM (mCRF-R2b) for 125I-[D-Tyr1]astressin binding inhibition.</p>Fórmula:C202H346N56O63SPureza:98%Cor e Forma:SolidPeso molecular:4599.35Calcitonin (human)
CAS:<p>Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.</p>Fórmula:C151H226N40O45S3Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:3417.87Isobutyryl-L-carnitine
CAS:<p>Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.</p>Fórmula:C11H21NO4Pureza:98%Cor e Forma:SolidPeso molecular:231.29Tienoxolol FA
<p>Tienoxolol FA, a beta-blocker for treating heart disease, hypertension, and ischemia.</p>Fórmula:C22H30N2O7SPureza:97.05% - 98.85%Cor e Forma:SoildPeso molecular:466.55Tabernanthalog
CAS:<p>TBG is a 5-HT2A agonist reducing alcohol/heroin cravings and promoting neuroplasticity with antidepressant effects in rodents.</p>Fórmula:C14H18N2OPureza:99.82% - 99.89%Cor e Forma:SoildPeso molecular:230.31Antidepressant agent 4
<p>Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.</p>Fórmula:C19H38ClN5O2SCor e Forma:SolidPeso molecular:436.06PD 142893
CAS:<p>PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.</p>Fórmula:C50H65N7O10Pureza:98%Cor e Forma:SolidPeso molecular:924.09GLP-1 (9-36) amide
CAS:<p>GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor.</p>Fórmula:C140H214N36O43Pureza:97%Cor e Forma:SolidPeso molecular:3089.41(Hyp³)-Bradykinin acetate
<p>(Hyp³)-Bradykinin acetate is an agonist of bradykinin B2 receptor and stimulates inositol phosphate production in cultured human fibroblasts.</p>Fórmula:C52H77N15O14Pureza:99.46%Cor e Forma:SolidPeso molecular:1136.26K1-70
<p>K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.</p>Cor e Forma:LiquidPeso molecular:145.5kDaGRPP (human)
CAS:<p>GRPP (human), a 30-amino-acid peptide derived from Gcg, modestly elevates plasma insulin levels while reducing plasma glucagon concentrations.</p>Fórmula:C136H215N41O58SCor e Forma:SolidPeso molecular:3384.47Seglitide acetate
CAS:<p>Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor.</p>Fórmula:C46H60N8O9Pureza:98.87%Cor e Forma:SolidPeso molecular:869.025-HT1AR/5-HT6R ligand-1
<p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>Fórmula:C25H29ClN4O2SCor e Forma:SolidPeso molecular:485.04Spantide I
CAS:<p>Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.</p>Fórmula:C75H108N20O13Pureza:98%Cor e Forma:SolidPeso molecular:1497.79MrgprX2 antagonist-4
CAS:<p>MrgprX2 antagonist-4, from patent US20210128561A1, inhibits MrgprX2 receptor; useful for skin inflammation studies.</p>Fórmula:C16H19N3OCor e Forma:SolidPeso molecular:269.348Tirzepatide TFA
<p>Tirzepatide TFA, a GIP and GLP-1 agonist, targets type 2 diabetes treatment.</p>Fórmula:C227H349F3N48O70Cor e Forma:SolidPeso molecular:4927.47N-Desmethyl Pimavanserin
CAS:<p>N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin and is used in the treatment of insomnia and other sleep disorders.</p>Fórmula:C24H32FN3O2Pureza:98.02%Cor e Forma:SolidPeso molecular:413.53GPR55 agonist 4
<p>GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].</p>Fórmula:C19H16FN5O2Cor e Forma:SolidPeso molecular:365.36Surfagon
CAS:<p>Surfagon is an effective LHRH agonist.</p>Fórmula:C56H78N16O12Pureza:98%Cor e Forma:SolidPeso molecular:1167.34ONO-0300302
CAS:<p>ONO-0300302: LPA1 antagonist, treats Benign Prostatic Hyperplasia, IC50 = 0.16 nM, reduces IUP in rats and dogs for 12h.</p>Fórmula:C29H35NO5Pureza:98%Cor e Forma:SolidPeso molecular:477.59Guanylin TFA (mouse,rat)
<p>Guanylin (mouse, rat) TFA is a peptide composed of 15 amino acids and acts as an activator of intestinal guanylate cyclase. This compound is utilized in research related to diarrhea.</p>Fórmula:C60H90N16O22S4·xC2HF3O2Cor e Forma:SolidPeso molecular:1515.71 (free base)isomer-Cilansetron
CAS:<p>isomer-Cilansetron is an isomer of Cilansetron.</p>Fórmula:C20H21N3OPureza:99.92% - 99.96%Cor e Forma:SoildPeso molecular:319.4Galanin (1-19), human
CAS:<p>Galanin (1-19), human: a fragment of GAL neuropeptide influencing hormone release, pain response, and eating behavior.</p>Fórmula:C89H130N26O25Pureza:98%Cor e Forma:SolidPeso molecular:1964.14PSA1 (141-150)
CAS:<p>This Prostate Specific Antigen 1 peptide was used in the immunotherapy of cancer experiments.</p>Fórmula:C55H93N13O13SPureza:98%Cor e Forma:SolidPeso molecular:1176.47Survodutide
CAS:<p>Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.</p>Fórmula:C192H289N47O61Pureza:99.83%Cor e Forma:SolidPeso molecular:4229.0957Misoprostol acid
CAS:<p>Misoprostol acid is an active metabolite of Misoprostol,can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.</p>Fórmula:C21H36O5Pureza:98%Cor e Forma:SolidPeso molecular:368.51KwFwLL-NH2
CAS:<p>KwFwLL-NH2 is a hexapeptide that serves as a ligand for the ghrelin receptor (ghrelin receptor). This compound acts as a specific inverse agonist for the ghrelin receptor, exhibiting moderate potency (EC50=45.6 nM).</p>Fórmula:C49H66N10O6Cor e Forma:SolidPeso molecular:891.11Orexin B, rat, mouse TFA
<p>Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.</p>Fórmula:C128H216F3N45O36SCor e Forma:SolidPeso molecular:3050.42Alosetron
CAS:<p>Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.</p>Fórmula:C17H18N4OPureza:98%Cor e Forma:Crystalline PowderPeso molecular:294.36Spantide acetate
<p>Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.</p>Fórmula:C77H112N20O15Pureza:98.9200%Cor e Forma:SolidPeso molecular:1557.84Y1 receptor antagonist 1 formic
<p>H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.</p>Fórmula:C29H35N5O5Cor e Forma:SolidPeso molecular:533.62Sphingosine-1-phosphate (d16:1)
CAS:<p>C16 S1P binds S1P1/EDG-1 (115%), S1P3/EDG-3 (83%), S1P2/EDG-5 (103%) receptors; elevated in glaucoma.</p>Fórmula:C16H34NO5PCor e Forma:SolidPeso molecular:351.424Prostaglandin J2
CAS:<p>PGJ2, a PGD2 metabolite, is a DP agonist (Ki: 0.9 nM hDP, 6.6 nM hCRTH2), induces cAMP (EC50: 1.2 nM), oxidative stress, neuronal apoptosis, and neurotoxicity.</p>Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.45PY-60
CAS:<p>PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2).Cost-effective and quality-assured.</p>Fórmula:C16H15N3O2SPureza:99.5% - 99.67%Cor e Forma:SolidPeso molecular:313.37Neuropeptide W-30 (human)
CAS:<p>Neuropeptide W-30 (human) serves as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It acts as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8, binding and activating them at comparable effective doses [1] [2] [3].</p>Fórmula:C165H249N49O37SCor e Forma:SolidPeso molecular:3543.11(+)-Oxypeucedanin methanolate
CAS:<p>(+)-Oxypeucedanin methanolate (compound 9) is a natural compound that inhibits prostaglandin E2 production [1].</p>Fórmula:C17H18O6Cor e Forma:SolidPeso molecular:318.32Adrogolide HCl
CAS:<p>Adrogolide Hydrochloride is a selective dopamine receptor D1 agonist.</p>Fórmula:C22H26ClNO4SCor e Forma:SolidPeso molecular:435.96Pasireotide pamoate
CAS:<p>Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.</p>Fórmula:C81H82N10O15Pureza:98%Cor e Forma:SolidPeso molecular:1435.58PACAP-38 (16-38), human, mouse, rat
CAS:<p>PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production</p>Fórmula:C123H215N39O28SPureza:98%Cor e Forma:SolidPeso molecular:2720.33CB1R agonist 1
<p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>Fórmula:C20H18F3N3O3SCor e Forma:SolidPeso molecular:437.435ACT-1016-0707
CAS:<p>ACT-1016-0707 is a selective, insurmountable LPA1 antagonist with antifibrotic and anti-inflammatory activity in lung fibrosis models</p>Fórmula:C19H23ClN4O4SPureza:99.905%Cor e Forma:SolidPeso molecular:438.93
