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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • Logotipo do CymitQuimica
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    MrgprX2 antagonist-7

    <p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>
    Fórmula:C24H22ClF3N6O3
    Cor e Forma:Solid
    Peso molecular:534.92

    Ref: TM-T63766

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    SB 258741 hydrochloride

    <p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>
    Fórmula:C19H31ClN2O2S
    Cor e Forma:Solid
    Peso molecular:386.98

    Ref: TM-T61724

  • MRS2179 tetrasodium hydrate
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    MRS2179 tetrasodium hydrate

    <p>MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.</p>
    Fórmula:C11H15N5Na4O10P2
    Cor e Forma:Solid
    Peso molecular:576.21

    Ref: TM-T64078

  • CCR1 antagonist 13
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    CCR1 antagonist 13

    CAS:
    <p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>
    Fórmula:C25H27ClFN3O4
    Cor e Forma:Solid
    Peso molecular:487.95

    Ref: TM-T207224

  • 2,3-dinor-11β-Prostaglandin F2α
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    2,3-dinor-11β-Prostaglandin F2α

    CAS:
    <p>2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where</p>
    Fórmula:C18H30O5
    Cor e Forma:Solid
    Peso molecular:326.43

    Ref: TM-T37275

  • Dinoxyline
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    Dinoxyline

    CAS:
    <p>Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.</p>
    Fórmula:C15H13NO3
    Cor e Forma:Solid
    Peso molecular:255.27

    Ref: TM-T201856

  • Taranabant
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    Taranabant

    CAS:
    <p>Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.</p>
    Fórmula:C27H25ClF3N3O2
    Pureza:99.06% - 99.06%
    Cor e Forma:Solid
    Peso molecular:515.96

    Ref: TM-T13080L

  • WIN 62577
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    WIN 62577

    CAS:
    <p>WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.</p>
    Fórmula:C29H31N3O
    Cor e Forma:Solid
    Peso molecular:437.576

    Ref: TM-T206261

  • (S)-YNT-3708
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    (S)-YNT-3708

    CAS:
    <p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>
    Fórmula:C35H36N4O6S
    Cor e Forma:Solid
    Peso molecular:640.749

    Ref: TM-T206866

  • Logotipo do CymitQuimica
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    MrgprX2 antagonist-6

    <p>MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.</p>
    Fórmula:C24H23F3N6O3
    Cor e Forma:Solid
    Peso molecular:500.47

    Ref: TM-T63394

  • DHICA
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    DHICA

    CAS:
    <p>DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.</p>
    Fórmula:C9H7NO4
    Cor e Forma:Solid
    Peso molecular:193.16

    Ref: TM-T201499

  • AL 8810
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    AL 8810

    CAS:
    <p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>
    Fórmula:C24H31FO4
    Cor e Forma:Solid
    Peso molecular:402.5

    Ref: TM-T21752

  • AB-FUBINACA 3-fluorobenzyl isomer
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    AB-FUBINACA 3-fluorobenzyl isomer

    CAS:
    <p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>
    Fórmula:C20H21FN4O2
    Cor e Forma:Solid
    Peso molecular:368.41

    Ref: TM-T201486

  • GLP-1 receptor agonist 16
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    GLP-1 receptor agonist 16

    CAS:
    <p>GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.</p>
    Fórmula:C33H31ClFN3O4
    Cor e Forma:Solid
    Peso molecular:588.068

    Ref: TM-T204526

  • Methacycline
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    Methacycline

    CAS:
    <p>Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.</p>
    Fórmula:C22H22N2O8
    Cor e Forma:Solid
    Peso molecular:442.42

    Ref: TM-T201726

  • RS 61756-007
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    RS 61756-007

    CAS:
    <p>RS 61756-007 is a selective thromboxane receptor (TP) agonist.</p>
    Fórmula:C23H28O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:384.47

    Ref: TM-T26141

  • ASN-1377642
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    ASN-1377642

    CAS:
    <p>ASN-1377642 is an NK1 receptor antagonist with a Ki value of 251 nM. It demonstrates antitumor activity in breast cancer cells with high expression of NK1R-Tr.</p>
    Fórmula:C21H16ClN5OS
    Cor e Forma:Solid
    Peso molecular:421.90

    Ref: TM-T207218

  • ZK118182 isopropyl ester
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    ZK118182 isopropyl ester

    CAS:
    <p>ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).</p>
    Fórmula:C23H37ClO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:428.99

    Ref: TM-T29225

  • U91356
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    U91356

    CAS:
    <p>U91356 is an agonist of the dopamine receptors.</p>
    Fórmula:C13H17N3O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:231.29

    Ref: TM-T13240

  • BMS-986104
    Targetmol
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    BMS-986104

    CAS:
    <p>BMS-986104 is an effective selective modulator of the S1P1 receptor. It demonstrates efficacy in the mouse EAE model, comparable to that of FTY720. Furthermore, BMS-986104 shows promising remyelination properties in three-dimensional brain cell cultures subjected to lysophosphatidylcholine (LPC)-induced demyelination.</p>
    Fórmula:C22H35NO
    Cor e Forma:Solid
    Peso molecular:329.52

    Ref: TM-T200882