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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • COX-2-IN-6
    Targetmol
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    COX-2-IN-6

    CAS:
    <p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>
    Fórmula:C20H27NO6S
    Pureza:99.29% - 99.69%
    Cor e Forma:Soild
    Peso molecular:409.5

    Ref: TM-T62061

  • PF-07054894
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    PF-07054894

    CAS:
    <p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>
    Fórmula:C24H30N6O4
    Cor e Forma:Solid
    Peso molecular:466.53

    Ref: TM-T73005

  • UTPγS trisodium salt
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    UTPγS trisodium salt

    CAS:
    <p>P2Y2 and P2Y4 receptor agonist</p>
    Fórmula:C9H12N2Na3O14P3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:566.15

    Ref: TM-T23499

  • AA 497 (Free Base)
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    AA 497 (Free Base)

    CAS:
    <p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>
    Fórmula:C14H21NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:251.32

    Ref: TM-T26359

  • Ophiobolin C
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    Ophiobolin C

    CAS:
    <p>inhibitor of human CCR5 binding to HIV-1 gp120</p>
    Fórmula:C25H38O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:386.57

    Ref: TM-T23108

  • Logotipo do CymitQuimica
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    SB 258741 hydrochloride

    <p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>
    Fórmula:C19H31ClN2O2S
    Cor e Forma:Solid
    Peso molecular:386.98

    Ref: TM-T61724

  • LY210073
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    LY210073

    CAS:
    <p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>
    Fórmula:C30H28O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:516.54

    Ref: TM-T15801

  • Disulergine
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    Disulergine

    CAS:
    <p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>
    Fórmula:C17H24N4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:348.46

    Ref: TM-T24003

  • Pexacerfont
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    Pexacerfont

    CAS:
    <p>Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).</p>
    Fórmula:C18H24N6O
    Pureza:99.77%
    Cor e Forma:Solid
    Peso molecular:340.42

    Ref: TM-T16475

  • TAK-075
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    TAK-075

    CAS:
    <p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>
    Fórmula:C36H46N4O4S
    Cor e Forma:Solid
    Peso molecular:630.84

    Ref: TM-T206506

  • RS 12254
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    RS 12254

    CAS:
    <p>RS 12254 is a dopamine agonist and antihypertensive agent.</p>
    Fórmula:C28H40N2O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:468.63

    Ref: TM-T26131

  • SR 140333
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    SR 140333

    CAS:
    <p>SR 140333 is a NK1 receptor antagonist.</p>
    Fórmula:C37H45Cl3N2O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:656.12

    Ref: TM-T23385

  • BMS-741672
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    BMS-741672

    CAS:
    <p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>
    Fórmula:C25H33F3N6O2
    Cor e Forma:Solid
    Peso molecular:506.56

    Ref: TM-T71640

  • F 14679
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    F 14679

    CAS:
    <p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>
    Fórmula:C21H25ClF2N4O
    Pureza:99.09%
    Cor e Forma:Solid
    Peso molecular:422.9

    Ref: TM-T62269

  • Logotipo do CymitQuimica
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    PAR4 antagonist 3

    CAS:
    <p>PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.</p>
    Fórmula:C22H16FN3O5S
    Peso molecular:453.44

    Ref: TM-T209701

  • Ro-24-4736
    Targetmol
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    Ro-24-4736

    CAS:
    <p>Ro 24-4736 is an effective and selective platelet-activating factor antagonist.</p>
    Fórmula:C31H20ClN5OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:546.04

    Ref: TM-T16768

  • Zafirlukast metabolite M1
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    Zafirlukast metabolite M1

    CAS:
    <p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>
    Fórmula:C25H25N3O4S
    Cor e Forma:Solid
    Peso molecular:463.549

    Ref: TM-T204861

  • SGLT1/2-IN-8
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    SGLT1/2-IN-8

    CAS:
    <p>SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.</p>
    Fórmula:C22H26O6
    Cor e Forma:Solid
    Peso molecular:386.438

    Ref: TM-T204130

  • Arpromidine
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    Arpromidine

    CAS:
    <p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>
    Fórmula:C21H25FN6
    Cor e Forma:Solid
    Peso molecular:380.462

    Ref: TM-T204236

  • Opipramol dihydrochloride
    Targetmol
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    Opipramol dihydrochloride

    CAS:
    <p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>
    Fórmula:C23H31Cl2N3O
    Cor e Forma:Solid
    Peso molecular:436.418

    Ref: TM-T204660