GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(1.025 produtos)
- Receptor de adenosina(251 produtos)
- Receptor adrenérgico(3.025 produtos)
- Receptor de Bombesina(35 produtos)
- Receptor de Bradicinina(61 produtos)
- CXCR(158 produtos)
- CaSR(34 produtos)
- Receptor de Canabinóides(218 produtos)
- Colecistocinina(1 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor Endotelina(86 produtos)
- Receptor GNRH(84 produtos)
- GPCR19(36 produtos)
- GRK(33 produtos)
- GTPase(23 produtos)
- Receptor Glucagon(195 produtos)
- Hedgehog/Smoothened(49 produtos)
- Receptor de Histamina(385 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
- PAFR(14 produtos)
- PKA(60 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 19 mais subcategorias
Foram encontrados 6011 produtos de "GPCR/Proteína-G"
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LAB687
CAS:LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.Fórmula:C26H23F3N2O3Cor e Forma:SolidPeso molecular:468.47GLP-1R modulator-1
CAS:GLP-1R modulator-1 (Compound 384) is a potent and orally active selective agonist of the glucagon-like peptide-1 receptor (GLP-1R). It activates G protein-coupled signaling, leading to increased intracellular cAMP levels, enhanced insulin secretion, delayed gastric emptying, and reduced appetite. GLP-1R modulator-1 holds potential for research in type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).Fórmula:C41H38ClFN6O4Cor e Forma:SolidPeso molecular:733.23Metrazoline
CAS:Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.
Fórmula:C14H16N2O4Cor e Forma:SolidPeso molecular:276.288Rimegepant sulfate hydrate
CAS:Rimegepant (BMS-927711/BHV-3000): oral CGRP blocker for migraines, effective without vasoconstriction, beats placebo, well-tolerated.Fórmula:C56H64F4N12O13SCor e Forma:SolidPeso molecular:1221.2526SST1 receptor antagonist-1
CAS:SST1 receptor antagonist-1 (Compound 23) is a selective antagonist of the somatostatin receptor 1 (SST1), showing a pKd of 9.11 for rSST1 and 8.79 for hSST1. This compound is applicable in research related to retinal and endocrine dysfunction, cancer, and neuropsychiatric disorders.Fórmula:C29H31F2N3O2Cor e Forma:SolidPeso molecular:491.57Ac-Atovaquone
CAS:Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Fórmula:C24H21ClO4Cor e Forma:SolidPeso molecular:408.87Pexacerfont
CAS:Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).Fórmula:C18H24N6OPureza:99.77%Cor e Forma:SolidPeso molecular:340.42MRGPRX2 modulator-3
CAS:MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and an MRGPRX2 regulator. It is utilized in the investigation of MRGPRX2-related conditions, including allergies, itching, pain, inflammation, and autoimmune diseases.Fórmula:C21H21ClF3N5OCor e Forma:SolidPeso molecular:451.87SGL5213
CAS:SGL5213 is a potent oral SGLT1 inhibitor (IC50: 29 nM) with potential for treating type 2 diabetes.Fórmula:C37H55N3O8Pureza:98%Cor e Forma:SolidPeso molecular:669.85GPR183 inverse agonist-1
CAS:GPR183 inverse agonist-1 (Compound 78) is an inverse agonist of GPR183. It inhibits GPR183-mediated Gi activation and β-arrestin2 recruitment while blocking PBMC migration. This compound is utilized in research concerning inflammation, autoimmune, and cancer-related diseases.Fórmula:C20H20BrN5O2Cor e Forma:SolidPeso molecular:442.31SphK2-IN-2
SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).Fórmula:C21H25ClN10OCor e Forma:SolidPeso molecular:468.94MDMB-FUBICA
CAS:MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.Fórmula:C23H25FN2O3Cor e Forma:SolidPeso molecular:396.455Dopamine D4 receptor ligand 3
CAS:Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Fórmula:C28H31N3O5Cor e Forma:SolidPeso molecular:489.56KARI 201 hydrochloride
CAS:KARI 201 hydrochloride is a selective, brain-penetrant, competitive inhibitor of acid sphingomyelinase (ASM) with an IC50 of 338.3 nM. It also acts as an agonist for the growth hormone-releasing peptide receptor (ghrelin receptor). Additionally, KARI 201 hydrochloride can enhance the neuropathological features of Alzheimer's disease.Fórmula:C14H29ClN4O2Cor e Forma:SolidPeso molecular:320.86Tipelukast
CAS:Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.Fórmula:C29H38O7SPureza:>99.99%Cor e Forma:SolidPeso molecular:530.67SSTR5 antagonist 2 TFA
CAS:Potent, oral SSTR5 antagonist 2 TFA may treat type 2 diabetes.Fórmula:C34H36F4N2O7Pureza:98%Cor e Forma:SolidPeso molecular:660.65Taprostene
CAS:Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.Fórmula:C24H30O5Cor e Forma:SolidPeso molecular:398.49CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:452.48OP-2507
CAS:OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.Fórmula:C25H41NO4Pureza:98%Cor e Forma:SolidPeso molecular:419.6U91356
CAS:U91356 is an agonist of the dopamine receptors.Fórmula:C13H17N3OPureza:98%Cor e Forma:SolidPeso molecular:231.29
