GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(1.025 produtos)
- Receptor de adenosina(249 produtos)
- Receptor adrenérgico(3.022 produtos)
- Receptor de Bombesina(35 produtos)
- Receptor de Bradicinina(61 produtos)
- CXCR(158 produtos)
- CaSR(34 produtos)
- Receptor de Canabinóides(217 produtos)
- Colecistocinina(1 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor Endotelina(86 produtos)
- Receptor GNRH(84 produtos)
- GPCR19(33 produtos)
- GRK(33 produtos)
- GTPase(23 produtos)
- Receptor Glucagon(194 produtos)
- Hedgehog/Smoothened(49 produtos)
- Receptor de Histamina(385 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
- PAFR(14 produtos)
- PKA(60 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 19 mais subcategorias
Foram encontrados 5984 produtos de "GPCR/Proteína-G"
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CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Fórmula:C21H28ClN5O3Cor e Forma:SolidPeso molecular:433.93Org-6906
CAS:DCB-3503, a tylophorine analog, may treat cancer and suppress immunity by blocking protein synthesis and modulating HSC70's ATPase activity.Fórmula:C13H16ClNPureza:98%Cor e Forma:SolidPeso molecular:221.73Methacycline
CAS:Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.Fórmula:C22H22N2O8Cor e Forma:SolidPeso molecular:442.42Toladryl
CAS:Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.Fórmula:C18H23NOCor e Forma:SolidPeso molecular:269.38LPA2 antagonist 6
CAS:LPA2 antagonist 6 (example 2) acts as an antagonist of Lp(a). It inhibits the formation of Lp(a) with an IC50 value of 2.33 nM, making it useful for cardiovascular disease research.Fórmula:C26H34Cl2N2O6Cor e Forma:SolidPeso molecular:541.464LTD4 antagonist 1
CAS:LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).Fórmula:C31H32F3N3O5SPureza:98%Cor e Forma:SolidPeso molecular:615.66SGL5213
CAS:SGL5213 is a potent oral SGLT1 inhibitor (IC50: 29 nM) with potential for treating type 2 diabetes.Fórmula:C37H55N3O8Pureza:98%Cor e Forma:SolidPeso molecular:669.85EP-3945
CAS:EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.Fórmula:C24H26N4O3Cor e Forma:SolidPeso molecular:418.488GLP-1 receptor agonist 15
CAS:GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.Fórmula:C32H31ClFN3O5Cor e Forma:SolidPeso molecular:592.057MK-3207 Hydrochloride
CAS:MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Fórmula:C31H30ClF2N5O3Pureza:98.19%Cor e Forma:SolidPeso molecular:594.05CB2R/5-HT1AR agonist 1
CAS:Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].Fórmula:C24H33NO3Cor e Forma:SolidPeso molecular:383.52Pexacerfont
CAS:Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).Fórmula:C18H24N6OPureza:99.77%Cor e Forma:SolidPeso molecular:340.42MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54MrgprX2 antagonist-7
MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.Fórmula:C24H22ClF3N6O3Cor e Forma:SolidPeso molecular:534.92GLP-1 receptor agonist 11
CAS:GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].Fórmula:C31H31ClFN3O4Cor e Forma:SolidPeso molecular:564.05WIN 62577
CAS:WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Fórmula:C29H31N3OCor e Forma:SolidPeso molecular:437.576Vibegron
CAS:Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53AFP-07
CAS:AFP-07 is a highly selective and potent agonist. It was used for the prostacyclin receptor.Fórmula:C22H29F2NaO5Pureza:98%Cor e Forma:SolidPeso molecular:434.45Abarelix acetate
CAS:Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Fórmula:C72H95ClN14O14·xC2H4O2Cor e Forma:SolidPeso molecular:1476.14RU 52583
CAS:RU 52583 is an alpha 2-adrenergic receptor antagonist.Fórmula:C18H20N2Pureza:98%Cor e Forma:SolidPeso molecular:264.36
