CAS 130-01-8

senecionine

Description:

Senecionine is a pyrrolizidine alkaloid, a class of compounds known for their complex bicyclic structures and potential toxicity. It is primarily derived from plants in the Asteraceae family, particularly those in the genus Senecio. Senecionine is characterized by its molecular formula, which typically includes nitrogen and various carbon and hydrogen atoms, contributing to its unique structural properties. This compound is known for its hepatotoxic effects, which can lead to liver damage upon ingestion, making it a subject of concern in herbal medicine and toxicology. Senecionine can also exhibit mutagenic properties, raising further health concerns. Its presence in certain plants can lead to accidental poisoning in livestock and humans, particularly when consumed in large quantities or over extended periods. As a result, understanding its chemical behavior, potential interactions, and effects on biological systems is crucial for assessing risks associated with exposure to this alkaloid.

Formula: C₁₈H₂₅NO₅

InChI: InChI=1/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-/m1/s1

InChI key: InChIKey=HKODIGSRFALUTA-JTLQZVBZSA-N

SMILES: O=C/1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)[C@H](C)C\C1=C\C)[H])[H]

Synonyms:

• (15Z)-12-hydroxysenecionan-11,16-dione
• (3Z,5R,6R,14aR,14bR)-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
• 12-Hydroxysenecionan-11,16-Dione
• Aureine
• NSC 89935
• Senecionan-11,16-dione, 12-hydroxy-
• Senecionin
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,14aR,14bR)-
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, [5R-(3Z,5R*,6R*,14aR*,14bR*)]-
• Senecionine
• (15cis)-12-Hydroxysenecionan-11,16-dione
• 16-dione,12-hydroxy-senecionan-1
• qlgn
• Senecionine/Aureine

Senecionine

CAS: 130-01-8

Senecionine analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₁₈H₂₅NO₅

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 335.41

Ref: 11-1828

(5R,6R,9a1R,14aR,Z)-3-Ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 335.3948

Ref: IN-DA000TUW

Senecionine

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Molecular weight: 335.40

Ref: 7W-GY5116

Senecionine

CAS: 130-01-8

Senecionine

Purity: ≥95%

Molecular weight: 335.39g/mol

Ref: 54-BUP04516

Senecionine 100 µg/mL in Methanol:Water

Controlled Product

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Color and Shape: Single Solution

Molecular weight: 335.39

Ref: 04-A16934000MW-100

Senecionine

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Purity: 95%~99%

Molecular weight: 335.4

Ref: BP-BP1283

Pyrrolizidine alkaloids Mixture 661 100 µg/mL in Methanol

Controlled Product

CAS: 101687-28-9, 10285-06-0, 10285-07-1, 127-30-0, 130-01-8, 13268-67-2, 15503-86-3, 2318-18-5, 303-33-3, 303-34-4, 38710-26-8, 41093-89-4, 480-54-6, 480-81-9, 520-68-3, 570-19-4, 6209-65-0, 65582-53-8, 72755-25-0, 95462-14-9, 95462-15-0

Color and Shape: Mixture

Ref: 04-A50000661ME

Senecionine

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Molecular weight: 335.40

Ref: 4Z-S-110001

Senecionine-d3

CAS: 130-01-8

Formula: C₁₈H₂₂D₃NO₅

Molecular weight: 338.42

Ref: 4Z-S-110003

Senecionine

CAS: 130-01-8

Senecionine (Senecionin) is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.

Formula: C₁₈H₂₅NO₅

Purity: 97.8% - 98.82%

Color and Shape: Solid

Molecular weight: 335.39

Ref: TM-TQ0192

Senecionine

CAS: 130-01-8

Natural alkaloid

Formula: C₁₈H₂₅NO₅

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 335.4

Ref: 5G-89789

Senecionine-D3

Controlled Product

CAS: 130-01-8

Formula: C₁₈H₂₂D₃NO₅

Color and Shape: White To Beige

Molecular weight: 338.41

Ref: TR-S258652

Senecionine

CAS: 130-01-8

Formula: C₁₈H₂₅NO₅

Color and Shape: Neat

Molecular weight: 335.39

Ref: TR-S258650

Senecionine

CAS: 130-01-8

Senecionine is a n-oxide that is found in the plant Senecio jacobaea. It has been shown to have insecticidal, antiparasitic, and anticancer activity. The mechanism of senecionine's cytotoxicity is not well understood, but it may be due to its ability to cause mitochondrial dysfunction and cell lysis. Senecionine also binds to p2y receptors, which are a family of G protein-coupled receptors that are involved in inflammation and immunity. The binding of senecionine to these receptors leads to the activation of phospholipase C and inhibition of adenylate cyclase. This results in an increase in intracellular calcium levels and subsequent cell lysis.

Formula: C₁₈H₂₅NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 335.39 g/mol

Ref: 3D-FS161593