CAS 480-81-9: Seneciphylline

Description: Seneciphylline is an alkaloid derived from plants in the Senecio genus, particularly known for its presence in certain species of the Asteraceae family. It is characterized by its complex bicyclic structure, which includes a pyrrolidine ring. Seneciphylline exhibits hepatotoxic properties, primarily due to its ability to form reactive metabolites that can damage liver cells. This compound has garnered interest in pharmacological research due to its potential effects on various biological systems, including its role in traditional medicine. However, its toxicity raises concerns regarding safety and therapeutic use. Seneciphylline is typically studied in the context of its effects on liver function and its potential implications in toxicology. As with many plant-derived alkaloids, the extraction and purification processes are critical for obtaining this compound in a laboratory setting, and its handling requires caution due to its toxic nature. Overall, while seneciphylline may have interesting biological activities, its safety profile necessitates careful consideration in any applications.

Formula: C₁₈H₂₃NO₅

InChI: InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1

InChI key: InChIKey=FCEVNJIUIMLVML-QPSVUOIXSA-N

SMILES: O=C1OC2CCN3CC=C(COC(=O)C(O)(C(=C)CC1=CC)C)C32

Synonyms:

• (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, (3Z,6R,14aR,14bR)-
• (15Z)-12-hydroxy-13,19-didehydrosenecionan-11,16-dione
• (3Z,6R,14aR,14bR)-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
• 13,19-Didehydro-12-hydroxysenecionan-11,16-dione
• Ccris 4336
• Hsdb 5188
• Jacodine
• Nci-C61165
• Nsc 30622
• Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-
• Seneciophylline
• Seneciphyllin
• Seniciphylline
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, [6R-(3Z,6R*,14aR*,14bR*)]-
• trans-15-Ethylidene-12beta-hydroxy-12alpha-methyl-13-methylenesenec-1-enine
• α-Longilobine
• Seneciphylline

Seneciphylline

CAS: 480-81-9

Seneciphylline analytical standard provided with chromatographic purity, to be used as reference material for qualitative …

• Formula: C₁₈H₂₃NO₅
• Purity: (GC) ≥90%
• Color and Shape: Powder
• Molecular weight: 333.39

[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, (3Z,6R,14aR,14bR)-

CAS: 480-81-9

• Formula: C₁₈H₂₃NO₅
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 333.37891999999994

Seneciphylline

CAS: 480-81-9

• Formula: C₁₈H₂₃NO₅
• Molecular weight: 333.38

Seneciphylline

CAS: 480-81-9

• Purity: ≥98%
• Molecular weight: 333.38g/mol

Seneciphylline 100 µg/mL in Methanol

CAS: 480-81-9

• Color and Shape: Single Solution

Pyrrolizidine alkaloids Mixture 661 100 µg/mL in Methanol

CAS: 101687-28-9 10285-06-0 10285-07-1 127-30-0 130-01-8 13268-67-2 15503-86-3 2318-18-5 303-33-3 303-34-4 38710-26-8 41093-89-4 480-54-6 480-81-9520-68-3 570-19-4 6209-65-0 65582-53-8 72755-25-0 95462-14-9 95462-15-0

• Color and Shape: Mixture

Seneciphylline

CAS: 480-81-9

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer …

• Formula: C₁₈H₂₃NO₅
• Purity: 95%~99%
• Molecular weight: 333.384

Seneciphylline

CAS: 480-81-9

• Formula: C₁₈H₂₃NO₅
• Molecular weight: 333.38

Seneciphylline-d3

CAS: 480-81-9

• Formula: C₁₈H₂₀D₃NO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 336.40

Seneciphylline

CAS: 480-81-9

Seneciphylline: hepatotoxic, mutagenic in Drosophila, passes into rat milk, affects key enzymes in rats.

• Formula: C₁₈H₂₃NO₅
• Purity: 99.53% - 99.84%
• Color and Shape: White Powder
• Molecular weight: 333.38

Seneciphylline

CAS: 480-81-9

Natural alkaloid

• Formula: C₁₈H₂₃NO₅
• Purity: ≥ 98.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 333.39

Seneciphylline

CAS: 480-81-9

Seneciphylline is a pyrrolizidine alkaloid, which is a naturally occurring compound derived from plants of …

• Formula: C₁₈H₂₃NO₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 333.38 g/mol

Seneciphylline 100 µg/mL in Water

CAS: 480-81-9

• Formula: C₁₈H₂₃NO₅
• Color and Shape: Single Solution
• Molecular weight: 333.38