CAS 13609-67-1

Hydrocortisone butyrate

Description:

Hydrocortisone butyrate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological formulations for the treatment of various skin conditions, such as eczema and psoriasis. It is characterized by its ability to reduce inflammation and alleviate symptoms like itching and redness. The substance is a white to off-white crystalline powder, which is typically soluble in organic solvents but has limited solubility in water. Hydrocortisone butyrate acts by binding to glucocorticoid receptors, modulating gene expression, and inhibiting the release of pro-inflammatory mediators. Its potency is enhanced by the butyrate ester, which improves skin penetration and bioavailability. The compound is often formulated in creams, ointments, or lotions for topical application, allowing for localized treatment with minimal systemic absorption. As with other corticosteroids, prolonged use may lead to side effects, including skin thinning and potential systemic effects, necessitating careful management and adherence to prescribed dosages.

Formula:C₂₅H₃₆O₆

InChI:InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1

InChI key:InChIKey=BMCQMVFGOVHVNG-TUFAYURCSA-N

SMILES:O(C(CCC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])[H]

Synonyms: