CAS 14484-47-0
:Deflazacort
Description:
Deflazacort is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of various inflammatory and autoimmune conditions. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in managing diseases such as rheumatoid arthritis, lupus, and certain skin disorders. Deflazacort is known for its relatively lower side effects compared to other corticosteroids, particularly in terms of weight gain and adrenal suppression. The compound is typically administered orally and is metabolized in the liver to its active form. Its mechanism of action involves binding to glucocorticoid receptors, leading to the regulation of gene expression and subsequent modulation of inflammatory mediators. Deflazacort is also noted for its favorable pharmacokinetic profile, which allows for once-daily dosing in many cases. As with all corticosteroids, long-term use requires careful monitoring due to potential side effects, including osteoporosis, hypertension, and increased susceptibility to infections.
Formula:C25H31NO6
InChI:InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
InChI key:InChIKey=FBHSPRKOSMHSIF-GRMWVWQJSA-N
SMILES:C(COC(C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)=N2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]
Synonyms:- (11β,16β)-11-hydroxy-2-methyl-5β-H-progna-1,4-dieno[17,16-d]Oxazolo-3,20-dione
- (11β,16β)-21-(Acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
- (4Ar,4Bs,5S,6As,9Ar,10As,10Bs)-6B-Acetyl-5-Hydroxy-4A,6A,8-Trimethyl-4A,4B,5,6,6A,6B,9A,10,10A,10B,11,12-Dodecahydro-9-Oxa-7-Aza-Pentaleno[2,1-A]Phenanthren-2-One
- (4aR,4bS,5S,6aS,9aR,10aS,10bS)-6b-acetyl-5-hydroxy-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one
- 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
- 2-(5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl)-2-oxoethyl acetate
- 2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate
- 2H-Naphth[2′,1′:4,5]indeno[1,2-d]oxazole, 5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione deriv.
- 5′H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2′-methyl-, (11β,16β)-
- 5′β<span class="text-smallcaps">H</span>-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-, 21-acetate
- Azacort
- Azacortinol
- Calcort
- Deflan
- Deflazacort Intermediate
- Dezacor
- Dezacort
- Dl 458It
- Emflaza
- Flantadin
- L 5458
- Lantadin
- Mdl 458
- Oxazacort
- Pregna-1,4-Diene-11B-Ol-17A,16A-D-2-Methyl-Oxazoline-3,20-Dione
- Deflazacort
- DEFLAZACORT
- Deflazacort intermediate(D5)
- See more synonyms
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Found 11 products.
Deflazacort
CAS:Formula:C25H31NO6Purity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:441.52GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol
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Color and Shape:ColourlessDeflazacort
CAS:Formula:C25H31NO6Purity:≥ 98.0%Color and Shape:White to almost white powderMolecular weight:441.52Deflazacort
CAS:Controlled ProductApplications A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and lupus.
References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),Formula:C25H31NO6Color and Shape:NeatMolecular weight:441.52Deflazacort-d3
CAS:Controlled ProductApplications Deflazacort-d3, is the labeled analogue of Deflazacort (D228975), a systemic corticosteroid, and a derivative of prednisolone. Used for rheumatoid arthritis and lupus.
References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),Formula:C25H28D3NO6Color and Shape:NeatMolecular weight:444.54Deflazacort
CAS:Controlled ProductDeflazacort is a corticosteroid used to treat chronic inflammatory diseases of the bowel and skin. It has been shown to inhibit the growth of human tumor xenografts in mice, although it is not active against bacteria or fungi. Deflazacort has also been shown to have an antimicrobial effect on human cells in culture. The mechanism of action is not known, but may be due to its ability to stimulate production of an antimicrobial protein called defensin. Deflazacort has also been shown to be effective in treating rheumatoid arthritis, lupus erythematosus, and other autoimmune diseases. Deflazacort has a side-effect profile that includes hypertension, hyperglycemia, hypokalemia, and gastrointestinal ulceration.Formula:C25H31NO6Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:441.52 g/mol21-Deacetoxy-21-dimethoxy Deflazacort
CAS:Controlled ProductFormula:C25H33NO6Color and Shape:NeatMolecular weight:443.533Deflazacort-d3 (Major)
CAS:Controlled ProductFormula:C25H28D3NO6Color and Shape:NeatMolecular weight:444.54
