CAS 2135-17-3: Flumetasone

Description: Flumetasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological applications. It is characterized by its potent glucocorticoid activity, which helps in reducing inflammation and alleviating symptoms associated with various skin conditions, such as eczema and psoriasis. Flumetasone is typically formulated in topical preparations, allowing for localized treatment with minimal systemic absorption. Its chemical structure features a fluorinated steroid backbone, which enhances its anti-inflammatory efficacy compared to non-fluorinated corticosteroids. The substance is known for its relatively low systemic side effects when applied topically, making it a preferred choice in dermatology. Additionally, flumetasone exhibits a favorable pharmacokinetic profile, with a rapid onset of action and a duration of effect that supports its therapeutic use. As with all corticosteroids, caution is advised regarding prolonged use, as it may lead to skin atrophy or other local adverse effects. Overall, flumetasone serves as an effective option in managing inflammatory skin disorders.

Formula: C₂₂H₂₈F₂O₅

InChI: InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=WXURHACBFYSXBI-GQKYHHCASA-N

SMILES: O=C1C=CC2(C(=C1)C(F)CC3C4CC(C)C(O)(C(=O)CO)C4(C)CC(O)C32F)C

Synonyms:

• (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6Alpha,8Xi,11Beta,14Xi,16Alpha)-6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 6-Alpha,9-Alpha-Difluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 6α,9α-Difluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 6α,9α-Difluoro-16α-methylprednisolone
• 6α-Fluorodexamethasone
• 6α-Fluorodexamethazone
• Anaprime
• Aniprime
• Aniprome
• Cortexillar
• Flucort
• Flucorticin
• Flumetasone
• Flumethason
• Flutamethasone
• Fluvet
• Methagon
• NSC 5402
• NSC 54702
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-
• Rs 2177
• U 10974
• Vecort

Flumethasone

CAS: 2135-17-3

Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.

• Formula: C₂₂H₂₈F₂O₅
• Purity: 99.91%
• Color and Shape: White Crystalline Powder
• Molecular weight: 410.45

Flumethasone

CAS: 2135-17-3

• Formula: C₂₂H₂₈F₂O₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 410.46

Flumethasone

CAS: 2135-17-3

• Purity: ≥98%
• Molecular weight: 410.45g/mol

Flumethasone

CAS: 2135-17-3

• Purity: 98%
• Molecular weight: 410.45g/mol

Flumethasone

CAS: 2135-17-3

• Formula: C₂₂H₂₈F₂O₅
• Purity: ≤ 0.5%
• Color and Shape: White or to almost white powder
• Molecular weight: 410.45

Flumethasone

CAS: 2135-17-3

• Formula: C₂₂H₂₈F₂O₅
• Color and Shape: Neat
• Molecular weight: 410.45

Flumetasone

CAS: 2135-17-3

• Formula: C₂₂H₂₈F₂O₅
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 410.46

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

CAS: 105102-22-5 1177-87-3 124-94-7 13609-67-1 14484-47-0 1524-88-5 2135-17-32152-44-5 25122-46-7 25122-57-0 3093-35-4 33564-31-7 356-12-7 378-44-9 3801-06-7 3870-07-3 426-13-1 4419-39-0 50-02-2 50-03-3 50-04-4 50-23-7 50-24-8 51022-69-6 51333-22-3 514-36-3 53-06-5 53-36-1 5534-09-8 5593-20-4 57524-89-7 66734-13-2 67-78-7 73771-04-7 76-25-5 80474-14-2 83-43-2 987-24-6

• Color and Shape: Mixture

6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (Flumetasone)

CAS: 2135-17-3

• Formula: C₂₂H₂₈F₂O₅
• Color and Shape: Neat
• Molecular weight: 410.45

Flumethasone

CAS: 2135-17-3

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₂H₂₈F₂O₅
• Color and Shape: Powder, White to almost white
• Molecular weight: 410.46

Flumethasone

CAS: 2135-17-3

Applications A glucocorticoid. An anti-inflammatory. References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), …

• Formula: C₂₂H₂₈F₂O₅
• Color and Shape: White To Off-White
• Molecular weight: 410.45

Flumethasone-d3

CAS: 2135-17-3

Applications Labelled Flumethasone (F455000). A glucocorticoid. An anti-inflammatory. References Matuszewski, B, et al.: Anal. Chem., …

• Formula: C₂₂H₂₅D₃F₂O₅
• Color and Shape: Neat
• Molecular weight: 413.47

Flumethasone

CAS: 2135-17-3

Fluorinated corticosteroid; anti-inflammatory; antipruritic; vasoconstrictor

• Formula: C₂₂H₂₈F₂O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 410.45 g/mol