CAS 2135-17-3

Flumetasone

Description:

Flumetasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological applications. It is characterized by its potent glucocorticoid activity, which helps in reducing inflammation and alleviating symptoms associated with various skin conditions, such as eczema and psoriasis. Flumetasone is typically formulated in topical preparations, allowing for localized treatment with minimal systemic absorption. Its chemical structure features a fluorinated steroid backbone, which enhances its anti-inflammatory efficacy compared to non-fluorinated corticosteroids. The substance is known for its relatively low systemic side effects when applied topically, making it a preferred choice in dermatology. Additionally, flumetasone exhibits a favorable pharmacokinetic profile, with a rapid onset of action and a duration of effect that supports its therapeutic use. As with all corticosteroids, caution is advised regarding prolonged use, as it may lead to skin atrophy or other local adverse effects. Overall, flumetasone serves as an effective option in managing inflammatory skin disorders.

Formula: C₂₂H₂₈F₂O₅

InChI: InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=WXURHACBFYSXBI-GQKYHHCASA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6Alpha,8Xi,11Beta,14Xi,16Alpha)-6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 6-Alpha,9-Alpha-Difluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 6α,9α-Difluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 6α,9α-Difluoro-16α-methylprednisolone
• 6α-Fluorodexamethasone
• 6α-Fluorodexamethazone
• Anaprime
• Aniprime
• Aniprome
• Cortexillar
• Flucort
• Flucorticin
• Flumetasone
• Flumethason
• Flutamethasone
• Fluvet
• Methagon
• NSC 5402
• NSC 54702
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-
• Rs 2177
• U 10974

Flumetasone

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 410.46

Ref: 3B-F0945

Flumethasone

CAS: 2135-17-3

Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.

Formula: C₂₂H₂₈F₂O₅

Purity: 99.38% - 99.96%

Color and Shape: White Crystalline Powder

Molecular weight: 410.45

Ref: TM-T1124

Flumethasone

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 410.46

Ref: 4Z-F-701

Flumethasone

CAS: 2135-17-3

Flumethasone

Purity: ≥98%

Molecular weight: 410.45g/mol

Ref: 54-BUP14608

Flumethasone

CAS: 2135-17-3

Flumethasone

Purity: 98%

Molecular weight: 410.45g/mol

Ref: 54-PC109252

Flumethasone

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Purity: ≤ 0.5%

Color and Shape: White or to almost white powder

Molecular weight: 410.45

Ref: 7W-GA2414

6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (Flumetasone)

Controlled Product

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Color and Shape: Neat

Molecular weight: 410.45

Ref: 86-MM0427.01

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Controlled Product

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Color and Shape: Mixture

Ref: 04-A50000094ME

Flumethasone

Controlled Product

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Color and Shape: Neat

Molecular weight: 410.45

Ref: 04-C13718500

Flumethasone-d3

Controlled Product

CAS: 2135-17-3

Applications Labelled Flumethasone (F455000). A glucocorticoid. An anti-inflammatory.
References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

Formula: C₂₂H₂₅D₃F₂O₅

Color and Shape: Neat

Molecular weight: 413.47

Ref: TR-F455002

Flumethasone

Controlled Product

CAS: 2135-17-3

Applications A glucocorticoid. An anti-inflammatory.
References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

Formula: C₂₂H₂₈F₂O₅

Color and Shape: White To Off-White

Molecular weight: 410.45

Ref: TR-F455000

Flumethasone

CAS: 2135-17-3

Formula: C₂₂H₂₈F₂O₅

Ref: TR-TRC-F455000

Flumethasone

Controlled Product

CAS: 2135-17-3

Fluorinated corticosteroid; anti-inflammatory; antipruritic; vasoconstrictor

Formula: C₂₂H₂₈F₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 410.45 g/mol

Ref: 3D-FF23328