CAS 302-27-2: Aconitine

Description: Aconitine is a potent alkaloid derived from various species of the Aconitum plant, commonly known as monkshood or wolfsbane. It is classified as a bicyclic compound and is known for its complex structure, which includes a fused bicyclic system and a tertiary amine. Aconitine is characterized by its high toxicity, primarily affecting the cardiovascular and nervous systems. It acts as a sodium channel blocker, leading to symptoms such as arrhythmias, hypotension, and potentially fatal respiratory failure upon ingestion. The substance is typically found in the roots and tubers of Aconitum species and has been historically used in traditional medicine, although its use is highly restricted due to safety concerns. Aconitine is also notable for its lipophilicity, which allows it to easily cross biological membranes. Due to its toxic nature, handling aconitine requires caution, and it is subject to regulatory controls in many countries. Its chemical properties and biological effects make it a subject of interest in pharmacology and toxicology research.

Formula: C₃₄H₄₇NO₁₁

InChI: InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23?,24+,25-,26?,27+,28?,29+,31+,32-,33?,34-/m1/s1

InChI key: InChIKey=XFSBVAOIAHNAPC-WVHIKZTMSA-N

SMILES: O=C(OC1C2C3CC1(O)C(OC)C(O)C2(OC(=O)C)C4C(OC)C5C6(COC)CN(CC)C4C35C(OC)CC6O)C=7C=CC=CC7

Synonyms:

• (1Beta,3Alpha,5Xi,6Alpha,14Alpha,15Alpha,16Beta)-8-(Acetyloxy)-20-Ethyl-3,13,15-Trihydroxy-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitan-14-Yl Benzoate
• (3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-8-(Acetyloxy)-20-Ethyl-3,13,15-Trihydroxy-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitan-14-Yl Benzoate
• (3Alpha,6Alpha,9Alpha,10Alpha,13Alpha,14Alpha,15Alpha,16Beta)-8-(Acetyloxy)-20-Ethyl-3,13,15-Trihydroxy-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitan-14-Yl Benzoate
• 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv.
• 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine-4,8,9,11,11a(1H,7H)-pentol, 1-ethyldecahydro-6,10,13-trimethoxy-3-(methoxymethyl)-, 11a-acetate 8-benzoate
• Acetylbenzoylaconine
• Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1α,3α,6α,14α,15α,16β)-
• Aconitin
• Aconitina

Aconitine, 98%

CAS: 302-27-2

Opens tetrodotoxin-sensitive sodium channels. Useful for creating models of cardiac arrhythmia This Thermo Scientific Chemicals …

• Formula: C₃₄H₄₇NO₁₁
• Purity: 98%
• Color and Shape: White to off-white, Powder
• Molecular weight: 645.75

LC PestiMix 6 10 µg/mL in Acetonitrile

CAS: 1007-28-9 1114-71-2 113036-88-7 113136-77-9 114420-56-3 115086-54-9 115852-48-7 116255-48-2 119791-41-2 121776-33-8 126535-15-7 130000-40-7 136849-15-5 138164-12-2 139528-85-1 147150-35-4 149508-90-7 180409-60-3 181274-17-9 1929-88-0 199119-58-9 2008-41-5 210631-68-8 211867-47-9 221667-31-8 223580-51-6 23576-24-1 239110-15-7 2439-10-3 25606-41-1 27314-13-2 27605-76-1 2797-51-5 302-27-2321-54-0 32889-48-8 3337-71-1 335104-84-2 33820-53-0 35367-31-8 37019-18-4 372137-35-4 4151-50-2 422556-08-9 42609-52-9 4849-32-5 55861-78-4 57160-47-1 58011-68-0 6119-70-6 61432-55-1 64-10-8 66-81-9 69335-91-7 69806-50-4 74051-80-2 74222-97-2 76578-12-6 8065-36-9 81103-11-9 81335-77-5 82211-24-3 838-85-7 86811-58-7 88678-67-5 90982-32-4 91-22-5 93697-74-6 944-22-9 951659-40-8 96182-53-5 96525-23-4 97780-06-8 97886-45-8 99105-77-8

• Color and Shape: Mixture

Aconitine

CAS: 302-27-2

Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum …

• Formula: C₃₄H₄₇NO₁₁
• Purity: 95%~99%
• Molecular weight: 645.746

Aconitine 100 µg/mL in Acetonitrile

CAS: 302-27-2

• Formula: C₃₄H₄₇NO₁₁
• Color and Shape: Single Solution
• Molecular weight: 645.74

Aconitine

CAS: 302-27-2

• Formula: C₃₄H₄₇NO₁₁
• Color and Shape: Neat
• Molecular weight: 645.74

Aconitine

CAS: 302-27-2

• Formula: C₃₄H₄₇NO₁₁
• Color and Shape: White To Off-White Solid
• Molecular weight: 645.75

Aconitine

CAS: 302-27-2

• Formula: C₃₄H₄₇NO₁₁
• Purity: ≥ 98.0%
• Color and Shape: White to off-wihite crystalline powder
• Molecular weight: 645.75

Aconitine

CAS: 302-27-2

Natural alkaloid

• Formula: C₃₄H₄₇NO₁₁
• Purity: ≥ 95.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 645.75

Aconitine

CAS: 302-27-2

Applications Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential …

• Formula: C₃₄H₄₇NO₁₁
• Color and Shape: Neat
• Molecular weight: 645.74

Aconitine

CAS: 302-27-2

Toxin with analgesic and antipyretic activity

• Formula: C₃₄H₄₇NO₁₁
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 645.75 g/mol