CAS 356-12-7: Fluocinonide
Description:Fluocinonide is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties, making it effective in treating various skin conditions such as eczema, psoriasis, and dermatitis. It is classified as a potent topical corticosteroid, which means it is designed for application directly to the skin. The chemical structure of fluocinonide includes a fluorinated steroid backbone, which enhances its potency and efficacy compared to non-fluorinated corticosteroids. It typically appears as a white to off-white crystalline powder and is poorly soluble in water but soluble in organic solvents. Fluocinonide works by inhibiting the release of inflammatory mediators and reducing the proliferation of skin cells, thereby alleviating symptoms like redness, itching, and swelling. Due to its potency, it is important to use fluocinonide under medical supervision to avoid potential side effects, such as skin thinning or systemic absorption, especially with prolonged use. As with all medications, proper dosage and application guidelines should be followed to ensure safety and effectiveness.
Formula:C26H32F2O7
InChI:InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
InChI key:InChIKey=WJOHZNCJWYWUJD-IUGZLZTKSA-N
SMILES:O=C1C=CC2(C(=C1)C(F)CC3C4CC5OC(OC5(C(=O)COC(=O)C)C4(C)CC(O)C32F)(C)C)C
- Synonyms:
- (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
- 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
- Biscosal
- Dermaplus
- Flucetonide
- Flucinar
- Fluocinolide
- Fluocinolide acetate
- Fluocinolone acetonide 21-acetate
- Fluocinolone acetonide acetate
- See more synonyms
- Fluocinonid
- Fluocinonide
- Fluocinonido
- Lidex
- Lidex E
- Metosyn
- Nsc 101791
- Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate
- Straderm
- Topsym
- Topsymin
- Topsyn
- Topsyne
- Vanos
- 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl acetate
- Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
- 2-(4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate
