CAS 426-13-1

Fluorometholone

Description:

Fluorometholone is a synthetic corticosteroid primarily used in ophthalmic formulations for its anti-inflammatory properties. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with various eye conditions, such as allergic conjunctivitis and post-operative inflammation. The chemical structure of fluorometholone includes a fluorine atom, which enhances its potency and reduces systemic side effects compared to other corticosteroids. It is typically administered as an eye drop solution, allowing for localized treatment with minimal systemic absorption. Fluorometholone exhibits a relatively low solubility in water, which can influence its formulation and delivery methods. The substance is known for its effectiveness in managing ocular inflammation while maintaining a favorable safety profile, making it a valuable option in ophthalmology. As with all corticosteroids, its use should be monitored to avoid potential side effects, including increased intraocular pressure and potential for cataract formation with prolonged use.

Formula: C₂₂H₂₉FO₄

InChI: InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1

InChI key: InChIKey=FAOZLTXFLGPHNG-KNAQIMQKSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(C)=O)(O)CC3)[H])(C[C@H](C)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
• 21-Desoxy-9α-fluoro-6-methylprednisolone
• 6α-Methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione
• 6α-Methyl-9α-fluoro-21-desoxyprednisolone
• 9α-Fluoro-11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione
• Cortilet
• Delmeson
• Efflumidex
• FML
• FML Forte
• FML Liquifilm
• Fluaton
• Fluaton PVA
• Flumetholon
• Flumetholone
• Fluor-Op
• Fluormetholon
• Fluorometholon
• Fluorometholone
• Fluorometolona
• Fml Sop
• Loticort
• Nsc-33001
• Oxylone
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-6α-methyl-
• U 8614
• Ursnon

Fluorometholone

CAS: 426-13-1

Fluorometholone

Formula: C₂₂H₂₉FO₄

Purity: 99.8%

Color and Shape: White To Off-White

Molecular weight: 376.20499

Ref: 47-573

Fluorometholone

CAS: 426-13-1

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₂H₂₉FO₄

Color and Shape: White Light Yellow Crystalline Powder

Molecular weight: 376.20499

Ref: 45-1278007

(6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 376.4617

Ref: IN-DA003QM3

Fluorometholone

CAS: 426-13-1

Fluorometholone

Purity: ≥98%

Molecular weight: 376.46g/mol

Ref: 54-BUP11691

Fluoromethalone

CAS: 426-13-1

Fluoromethalone

Purity: 99%

Molecular weight: 376.46g/mol

Ref: 54-PC109068

Fluorometholone

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 376.46

Ref: 7W-GP8238

Fluorometholone

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Color and Shape: White To Off-White Solid

Molecular weight: 376.47

Ref: 4Z-F-641

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Controlled Product

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Color and Shape: Mixture

Ref: 04-A50000094ME

Fluorometholone

Controlled Product

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Color and Shape: Neat

Molecular weight: 376.46

Ref: 04-C13793500

Fluorometholone

Controlled Product

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Color and Shape: Neat

Molecular weight: 376.46

Ref: 86-MM0870.00

Fluorometholone

CAS: 426-13-1

Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery.

Formula: C₂₂H₂₉FO₄

Purity: 99% - 99.15%

Color and Shape: Solid

Molecular weight: 376.46

Ref: TM-T3316

Fluorometholone RS

CAS: 426-13-1

Color and Shape: White To Light Yellow-White Solid Crystalline Powder

Ref: 2K-1134000021

Fluorometholone

Controlled Product

CAS: 426-13-1

Applications Fluorometholone is a glucocorticoid; anti-inflammatory.
References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),

Formula: C₂₂H₂₉FO₄

Color and Shape: White To Off-White

Molecular weight: 376.46

Ref: TR-F593145

Fluorometholone

Controlled Product

CAS: 426-13-1

Fluorometholone is a fluorocorticoid that is used to treat inflammatory conditions of the skin, eye, and airways. It has been shown to be effective against microbial infections in animals by inhibiting the production of fatty acids and reducing inflammation. Fluorometholone has also been shown to inhibit glucocorticoid receptors in cells, which may lead to less side effects when compared with other corticosteroids.
The drug is injected into the affected area, or taken orally as an injection solution. In cases of severe inflammation, it can be administered intravenously or intramuscularly. Fluorometholone can also be given topically, but this is not common due to its high potency.

Formula: C₂₂H₂₉FO₄

Purity: Min. 97 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 376.46 g/mol

Ref: 3D-FF23440

Fluorometholone

CAS: 426-13-1

Formula: C₂₂H₂₉FO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 376.47

Ref: 3B-F0414