CAS 4419-39-0
:Beclomethasone
Description:
Beclomethasone is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is commonly administered in the form of inhalers, nasal sprays, or topical formulations to treat conditions such as asthma, allergic rhinitis, and various skin disorders. The substance functions by inhibiting the release of inflammatory mediators, thereby reducing swelling and irritation in affected tissues. Beclomethasone has a relatively low systemic bioavailability when inhaled, which minimizes potential side effects compared to systemic corticosteroids. Its chemical structure features a steroid backbone with specific functional groups that contribute to its potency and selectivity for glucocorticoid receptors. The compound is generally well-tolerated, although long-term use may lead to side effects such as adrenal suppression or local irritation. As with any medication, it is essential to use beclomethasone under medical supervision to ensure appropriate dosing and to monitor for any adverse effects.
Formula:C22H29ClO5
InChI:InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
InChI key:InChIKey=NBMKJKDGKREAPL-DVTGEIKXSA-N
SMILES:Cl[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:- (11β,16β)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- (8S,10S,11S,13S,16S)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- 4419-39-0
- 9-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
- 9-Chloro-11β,17,21-trihydroxy-16β-methyl-pregna-1,4-diene-3,20-dione
- 9-Chloro-16β-methylprednisolone
- 9α-Chloro-16β-methylprednisolone
- Beclometason
- Beclometasona
- Beclometasone
- Beclometasone 17,21-Dipropionate
- Becolvent
- Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-
- See more synonyms
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Found 10 products.
Beclomethasone (9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione)
CAS:Halogenated derivatives of adrenal cortical hormonesFormula:C22H29ClO5Color and Shape:White PowderMolecular weight:408.17035Beclometasone (Beclomethasone)
CAS:Formula:C22H29ClO5Color and Shape:White To Off-White SolidMolecular weight:408.92GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol
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Color and Shape:Mixture9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Beclometasone)
CAS:Controlled ProductFormula:C22H29ClO5Color and Shape:NeatMolecular weight:408.92Beclometasone
CAS:Beclometasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.Formula:C22H29ClO5Purity:99.41% - 99.68%Color and Shape:White To Off-White Crystalline PowderMolecular weight:408.92Beclomethasone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).<br>References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),<br></p>Formula:C22H29ClO5Color and Shape:Off-WhiteMolecular weight:408.92Beclomethasone - 98% min
CAS:Controlled Product<p>Beclomethasone is a synthetic glucocorticoid that has significant effects on the bronchial system. It is used for the treatment of bronchial asthma and other diseases of the airways. Beclomethasone may be administered by inhalation, orally, or topically. Beclomethasone binds to cytoplasmic receptors in target cells and inhibits phospholipases, which are enzymes that release arachidonic acid from cell membranes. This process inhibits the production of leukotrienes, prostaglandins, and thromboxanes-all compounds that have been implicated in inflammation and bronchial asthma. The pharmacokinetic profile of Beclomethasone includes a high volume of distribution and low protein binding. Beclomethasone has been shown to inhibit nuclear receptors such as PPARα and GR, which regulate gene transcription for lipid metabolism.</p>Formula:C22H29ClO5Purity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:408.92 g/molBeclomethasone - 95% min
CAS:Controlled ProductBeclomethasone is a synthetic glucocorticoid that has been approved for the treatment of asthma and inflammatory bowel disease. It reduces inflammation by suppressing the immune system response. Beclomethasone has also been used in clinical studies to treat bronchial, bowel disease, and natriuretic effects due to its ability to increase magnesium levels in the body. Clinical trials have shown that beclomethasone can be used as an effective therapy for asthma. This drug also has anti-inflammatory properties and may be useful in treating infectious diseases such as tuberculosis. Beclomethasone has been shown to be effective against many different types of bacteria including Mycobacterium tuberculosis and Streptococcus pneumoniae.Formula:C22H29ClO5Purity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:408.92 g/mol
