CAS 480-54-6

Retrorsine

Description:

Retrorsine is a naturally occurring alkaloid primarily found in certain plants, particularly those in the Senecio genus. It is classified as a pyrrolizidine alkaloid, which is known for its potential hepatotoxicity and carcinogenic properties. Retrorsine has a complex bicyclic structure that includes a pyrrolizidine ring, contributing to its biological activity. The substance is often studied for its effects on liver function and its role in plant defense mechanisms. Retrorsine can be toxic to livestock and humans if ingested in significant amounts, leading to conditions such as veno-occlusive disease. Due to its toxicological profile, it is important to handle retrorsine with caution in laboratory settings. Additionally, its presence in herbal remedies and traditional medicines raises concerns regarding safety and regulation. Overall, retrorsine serves as an important subject of research in toxicology and pharmacology, highlighting the need for awareness regarding the consumption of plants containing this alkaloid.

Formula: C₁₈H₂₅NO₆

InChI: InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1

InChI key: InChIKey=BCJMNZRQJAVDLD-CQRYIUNCSA-N

SMILES: O=C/1O[C@]2([C@]3(C(COC(=O)[C@](CO)(O)[C@H](C)C\C1=C\C)=CCN3CC2)[H])[H]

Synonyms:

• (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3Z,5R,6S,14aR,14bR)-
• (15Z)-12,18-dihydroxysenecionan-11,16-dione
• (3Z,5R,6S,14aR,14bR)-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
• 12,18-Dihydroxy-senecionan-11,16-dione
• 3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
• Ccris 4338
• Hsdb 3530
• Nsc 107659
• Retrorsin
• Senecionan-11,16-dione, 12,18-dihydroxy-
• Senecionan-11,16-dione, 12,18-dihydroxy- (9CI)
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, [5R-(3Z,5R*,6S*,14aR*,14bR*)]-
• beta-Longilobine
• cis-Retronecic acid ester of retronecine
• trans-15-Ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-enine
• β-Longilobine

Retrorsine

CAS: 480-54-6

Formula: C₁₈H₂₅NO₆

Purity: 95%~99%

Molecular weight: 351.399

Ref: BP-BP1206

Pyrrolizidine alkaloids Mixture 661 100 µg/mL in Methanol

Controlled Product

CAS: 101687-28-9, 10285-06-0, 10285-07-1, 127-30-0, 130-01-8, 13268-67-2, 15503-86-3, 2318-18-5, 303-33-3, 303-34-4, 38710-26-8, 41093-89-4, 480-54-6, 480-81-9, 520-68-3, 570-19-4, 6209-65-0, 65582-53-8, 72755-25-0, 95462-14-9, 95462-15-0

Color and Shape: Mixture

Ref: 04-A50000661ME

Retrorsine 100 µg/mL in Water

Controlled Product

CAS: 480-54-6

Formula: C₁₈H₂₅NO₆

Color and Shape: Single Solution

Molecular weight: 351.39

Ref: 04-A16812500WA-100

Retrorsine

CAS: 480-54-6

Retrorsine hinders liver cell growth and aids research on liver damage by eliciting progenitor cells.

Formula: C₁₈H₂₅NO₆

Purity: 97.73%

Color and Shape: Solid

Molecular weight: 351.39

Ref: TM-TN2147

Retrorsine

CAS: 480-54-6

Formula: C₁₈H₂₅NO₆

Molecular weight: 351.40

Ref: 4Z-R-135001

Retrorsine-d3

CAS: 480-54-6

Formula: C₁₈H₂₂D₃NO₆

Molecular weight: 354.42

Ref: 4Z-R-135002

Retrorsine

CAS: 480-54-6

Natural alkaloid

Formula: C₁₈H₂₅NO₆

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Crystals

Molecular weight: 351.4

Ref: 5G-89775

Retrorsine

CAS: 480-54-6

Pyrrolizidine alkaloid

Formula: C₁₈H₂₅NO₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 351.39 g/mol

Ref: 3D-FR161611