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CAS 480-81-9

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Seneciphylline

Description:
Seneciphylline is an alkaloid derived from plants in the Senecio genus, particularly known for its presence in certain species of the Asteraceae family. It is characterized by its complex bicyclic structure, which includes a pyrrolidine ring. Seneciphylline exhibits hepatotoxic properties, primarily due to its ability to form reactive metabolites that can damage liver cells. This compound has garnered interest in pharmacological research due to its potential effects on various biological systems, including its role in traditional medicine. However, its toxicity raises concerns regarding safety and therapeutic use. Seneciphylline is typically studied in the context of its effects on liver function and its potential implications in toxicology. As with many plant-derived alkaloids, the extraction and purification processes are critical for obtaining this compound in a laboratory setting, and its handling requires caution due to its toxic nature. Overall, while seneciphylline may have interesting biological activities, its safety profile necessitates careful consideration in any applications.
Formula:C18H23NO5
InChI:InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1
InChI key:InChIKey=FCEVNJIUIMLVML-QPSVUOIXSA-N
SMILES:O=C/1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)C(=C)C\C1=C\C)[H])[H]
Synonyms:
  • (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, (3Z,6R,14aR,14bR)-
  • (15Z)-12-hydroxy-13,19-didehydrosenecionan-11,16-dione
  • (3Z,6R,14aR,14bR)-3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
  • 13,19-Didehydro-12-hydroxysenecionan-11,16-dione
  • Ccris 4336
  • Hsdb 5188
  • Jacodine
  • Nci-C61165
  • Nsc 30622
  • Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-
  • See more synonyms
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