CAS 53-06-5

Cortisone

Description:

Cortisone, with the CAS number 53-06-5, is a steroid hormone that belongs to the class of glucocorticoids. It is produced naturally in the adrenal cortex and plays a crucial role in the regulation of metabolism, immune response, and stress response. Cortisone is characterized by its anti-inflammatory and immunosuppressive properties, making it valuable in medical treatments for conditions such as arthritis, allergies, and autoimmune disorders. Chemically, cortisone is a derivative of cortisol, differing primarily in its ketone structure at the C11 position. It has a molecular formula of C21H28O5 and a molecular weight of approximately 360.45 g/mol. Cortisone is typically administered in its acetate form for therapeutic purposes, enhancing its solubility and bioavailability. Its pharmacological effects are mediated through the binding to glucocorticoid receptors, influencing gene expression and cellular activity. While effective in treating various conditions, cortisone can also have side effects, particularly with long-term use, including potential impacts on metabolism, bone density, and immune function.

Formula: C₂₁H₂₈O₅

InChI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=MFYSYFVPBJMHGN-ZPOLXVRWSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(C(=O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (8Xi,9Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,11,20-Trione
• 11-Dehydro-17-hydroxycorticosterone
• 17,21-Dihydroxypregn-4-Ene-3,11,20-Trione
• 17-Alpha,21-Dihydroxypregn-4-Ene-3,11,20-Trione
• 17-Hydroxy-11-dehydrocorticosterone
• 17α,21-Dihydroxy-4-pregnene-3,11,20-trione
• 17α,21β-Dihydroxy-4-pregnene-3,11,20-trione
• 17α-Hydroxy-11-dehydrocorticosterone
• Adrenalex
• Compound E
• Cortisate
• Cortison
• Cortisona
• Cortivite
• Cortogen
• Cortone
• KE
• Kendall's compound E
• Nsc 9703
• Pregn-4-en-17α,21-diol-3,11,20-trione
• Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-
• Reichstein's substance Fa
• Wintersteiner's compound F
• Δ4-Pregnene-17α,21-diol-3,11,20-trione
• Δ⁴-Pregnene-17α,21-diol-3,11,20-trione
• Cortisone

Cortisone

CAS: 53-06-5

Color and Shape: Neat

Ref: 61-FOR0214.00

Cortisone

CAS: 53-06-5

Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity.

Formula: C₂₁H₂₈O₅

Purity: 95.48% - 99.5%

Color and Shape: Solid

Molecular weight: 360.44

Ref: TM-T2884

Cortisone (Hydrocortisone EP Impurity B)

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Molecular weight: 360.45

Ref: 4Z-C-491003

Cortisone

Controlled Product

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Color and Shape: Neat

Molecular weight: 360.44

Ref: 04-C11705400

Cortisone

Controlled Product

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Color and Shape: Neat

Molecular weight: 360.44

Ref: 86-MM0214.00

Cortisone

CAS: 53-06-5

Color and Shape: Neat

Ref: LP-COR-1633-10

Cortisone

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 360.45

Ref: 3B-C1317

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Controlled Product

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Color and Shape: Mixture

Ref: 04-A50000094ME

Cortisone 0.1 mg/ml in Methanol

CAS: 53-06-5

Color and Shape: Single Solution

Ref: 61-AMP0214.00-02

Cortisone

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 360.44

Ref: 7W-GP7495

17a,21-Dihydroxypregn-4-ene-3,11,20-trione

CAS: 53-06-5

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 360.45

Ref: 10-F374672

Cortisone

CAS: 53-06-5

Purity: 97%

Molecular weight: 360.45001220703125

Ref: 10-F787616

Cortisone

CAS: 53-06-5

Impurity Hydrocortisone EP Impurity B
Applications Glucocorticoid, anti-inflammatory agent. Hydrocortisone EP Impurity B.
References Honda, A., et al.: J. Biol. Chem., 268, 7759 (1993); Narko, K., et al.: J. Clin. Endocrinol. Metab., 86, 1765 (2001); Michael, A., et al.: Reproduction, 126, 425 (2003);

Formula: C₂₁H₂₈O₅

Color and Shape: Beige

Molecular weight: 360.44

Ref: TR-C696500

Hydrocortisone EP Impurity B

CAS: 53-06-5

Formula: C₂₁H₂₈O₅

Molecular weight: 360.4

Ref: ST-EA-CP-H9002

Cortisone-d8 (Major)

Controlled Product

CAS: 53-06-5

Applications Labelled Cortisone (C696500). Glucocorticoid, anti-inflammatory agent.
References Honda, A., et al.: J. Biol. Chem., 268, 7759 (1993), Narko, K., et al.: J. Clin. Endocrinol. Metab., 86, 1765 (2001), Michael, A., et al.: Reproduction, 126, 425 (2003),

Formula: C₂₁D₈H₂₀O₅

Color and Shape: Off-White

Molecular weight: 368.4933

Ref: TR-C696502

Cortisone

Controlled Product

CAS: 53-06-5

Cortisone is a steroid hormone that belongs to the group of glucocorticoids. It is used in the treatment of inflammatory conditions, such as infectious diseases and asthma. Cortisone has been shown to have anti-inflammatory effects and can be used for the treatment of these conditions. Cortisone inhibits adipose tissue development by suppressing the expression of lipogenic enzymes and genes, which are involved in lipid synthesis. Cortisone has also been shown to have potential as a biomarker for identification of inflammation and infection, with higher levels found in patients with active inflammation or infection.

Formula: C₂₁H₂₈O₅

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 360.44 g/mol

Ref: 3D-FC20558