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CAS 67-78-7

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triamcinolone diacetate

Description:
Triamcinolone diacetate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is characterized by its ability to inhibit the release of inflammatory mediators and modulate immune responses, making it effective in treating various conditions such as allergies, skin disorders, and certain autoimmune diseases. The compound is typically administered via injection or topical formulations, allowing for localized or systemic effects. Chemically, it is a derivative of triamcinolone, featuring two acetyl groups that enhance its lipophilicity and bioavailability. Triamcinolone diacetate is known for its relatively long duration of action compared to other corticosteroids, which can be advantageous in therapeutic settings. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through urine. As with other corticosteroids, potential side effects may include skin atrophy, hormonal imbalances, and increased susceptibility to infections, necessitating careful monitoring during treatment. Overall, triamcinolone diacetate is a valuable agent in the management of inflammatory and allergic conditions, reflecting the broader utility of corticosteroids in clinical practice.
Formula:C28H35FO8
InChI:InChI=1/C25H31FO8/c1-13(27)33-12-20(31)25(32)21(34-14(2)28)10-18-17-6-5-15-9-16(29)7-8-22(15,3)24(17,26)19(30)11-23(18,25)4/h7-9,17-19,21,30,32H,5-6,10-12H2,1-4H3/t17?,18?,19-,21+,22-,23-,24-,25+/m0/s1
InChI key:InChIKey=XGMPVBXKDAHORN-RBWIMXSLSA-N
SMILES:C[C@@]12[C@]([C@]3([C@](F)([C@@H](O)C1)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])(C[C@@H](OC(C)=O)[C@@]2(C(COC(C)=O)=O)O)[H]
Synonyms:
  • (11Beta,16Alpha)-9-Fluoro-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Diene-16,21-Diyl Diacetate
  • (11beta,16alpha)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
  • (11β,16α)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
  • (8Xi,11Beta,14Xi,16Alpha)-9-Fluoro-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Diene-16,21-Diyl Diacetate
  • 16-(Acetyloxy)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
  • 16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione
  • 16α-Hydroxy-9α-fluoroprednisolone diacetate
  • 21-Diacetate
  • 8357Rp
  • 9-Alpha-Fluoro-16-Alpha-Hydroxyprednisolonediacetate
  • See more synonyms
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