Bcr-Abl
Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.
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Dasatinib monohydrate
CAS:863127-77-9
Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.
Formula:
C22H28ClN7O3S
Purity:
100% - 99.89%
Color and Shape:
Solid
Molecular weight:
506.03
Ref: TM-T1448L
| 50mg | 44.00 € | ||
| 100mg | 59.00 € | ||
| 200mg | 77.00 € | ||
| 500mg | 103.00 € | ||
| 1mL*10mM (DMSO) | 48.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Dasatinib
CAS:302962-49-8
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and …
Formula:
C22H26ClN7O2S
Purity:
99.62% - 99.89%
Color and Shape:
Pale-Yellow Solid
Molecular weight:
488.01
Ref: TM-T1448
| 1g | 137.00 € | ||
| 50mg | 44.00 € | ||
| 100mg | 58.00 € | ||
| 200mg | 69.00 € | ||
| 500mg | 95.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Lyn-IN-1
CAS:887650-05-7
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn
Formula:
C30H31F3N8O
Purity:
97% - 99.33%
Color and Shape:
Solid
Molecular weight:
576.62
Ref: TM-T11916
| 1mg | 46.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 82.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 385.00 € | ||
| 100mg | 550.00 € | ||
| 200mg | 799.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Imatinib Mesylate
CAS:220127-57-1
Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, …
Formula:
C29H31N7O·CH4SO3
Purity:
100% - 98.92%
Color and Shape:
White Crystalline Powder
Molecular weight:
589.71
Ref: TM-T1621
| 1u | 163.20 € | ||
| 200mg | 59.00 € | ||
| 500mg | 89.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
N-Desmethyl imatinib
CAS:404844-02-6
N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target …
Formula:
C28H29N7O
Purity:
98.60%
Color and Shape:
Off-White To Pale-Yellow Solid
Molecular weight:
479.58
Ref: TM-T11641
| 1mg | 91.00 € | ||
| 5mg | 167.00 € | ||
| 10mg | 316.00 € | ||
| 25mg | 534.00 € | ||
| 50mg | 768.00 € | ||
| 100mg | 1,060.00 € | ||
| 1mL*10mM (DMSO) | 177.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Bosutinib
CAS:380843-75-4
Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl …
Formula:
C26H29Cl2N5O3
Purity:
98.98% - 99.9%
Color and Shape:
Yellowish-Orange Or Pink To Brownish Solid Solid Powder
Molecular weight:
530.45
Ref: TM-T0152
| 5mg | 44.00 € | ||
| 10mg | 54.00 € | ||
| 25mg | 68.00 € | ||
| 50mg | 89.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 140.00 € | ||
| 500mg | 225.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
LXH254
CAS:1800398-38-2
LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM …
Formula:
C25H25F3N4O4
Purity:
98.3% - 99.92%
Color and Shape:
Solid
Molecular weight:
502.49
Ref: TM-T11898
| 1mg | 52.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 355.00 € | ||
| 50mg | 555.00 € | ||
| 100mg | 675.00 € | ||
| 200mg | 927.00 € | ||
| 500mg | 1,413.00 € | ||
| 1mL*10mM (DMSO) | 134.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Nilotinib
CAS:641571-10-0
Nilotinib (AMN107) is a Bcr-Abl tyrosine kinase inhibitor. Nilotinib has antitumor activity and may be …
Formula:
C28H22F3N7O
Purity:
99.61% - 99.83%
Color and Shape:
Off-White Solid
Molecular weight:
529.52
Ref: TM-T1524
| 50mg | 46.00 € | ||
| 100mg | 54.00 € | ||
| 200mg | 59.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
AKE-72
CAS:2566525-18-4
AKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of Ba/F3 cells expressing …
Formula:
C30H29F3N6O
Purity:
98.3%
Color and Shape:
Soild
Molecular weight:
546.59
Ref: TM-T80676
| 1mg | 152.00 € | ||
| 5mg | 363.00 € | ||
| 10mg | 532.00 € | ||
| 25mg | 819.00 € | ||
| 50mg | 1,100.00 € | ||
| 100mg | 1,507.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
DPH
CAS:484049-04-9
DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular …
Formula:
C18H13FN4O2
Purity:
99.72%
Color and Shape:
Solid
Molecular weight:
336.32
Ref: TM-T15164
| 1mg | 36.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 366.00 € | ||
| 100mg | 547.00 € | ||
| 1mL*10mM (DMSO) | 83.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
AD57
CAS:1093380-42-7
AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM …
Formula:
C22H20F3N7O
Purity:
98.23%
Color and Shape:
Soild
Molecular weight:
455.44
Ref: TM-T22552L
| 1mg | 34.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 112.00 € | ||
| 10mg | 205.00 € | ||
| 25mg | 346.00 € | ||
| 50mg | 494.00 € | ||
| 100mg | 672.00 € | ||
| 200mg | 906.00 € | ||
| 1mL*10mM (DMSO) | 129.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
c-ABL-IN-5
C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier …
Formula:
C19H17F2N3O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
341.35
Ref: TM-T79716
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 3 Dec 2024
Imatinib impurities3
CAS:404844-11-7
Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for …
Formula:
C24H20ClN5O
Purity:
97.05%
Color and Shape:
Liquid
Molecular weight:
429.9
Ref: TM-T67847
| 10mg | 43.00 € | ||
| 25mg | 70.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 133.00 € | ||
| 200mg | 185.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
Bosutinib hydrate
CAS:918639-08-4
Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for …
Formula:
C26H31Cl2N5O4
Purity:
99.87%
Color and Shape:
Solid
Molecular weight:
548.46
Ref: TM-T63875
| 5mg | 39.00 € | ||
| 10mg | 58.00 € | ||
| 25mg | 86.00 € | ||
| 50mg | 105.00 € | ||
| 100mg | 157.00 € | ||
| 500mg | 307.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
GNF-2
CAS:778270-11-4
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.
Formula:
C18H13F3N4O2
Purity:
99.08% - ≥95%
Color and Shape:
Solid
Molecular weight:
374.32
Ref: TM-T1817
| 5mg | 43.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 116.00 € | ||
| 50mg | 203.00 € | ||
| 100mg | 302.00 € | ||
| 200mg | 436.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
GMB-475
CAS:2490599-18-1
GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.
Formula:
C43H46F3N7O7S
Purity:
100% - 98.78%
Color and Shape:
Solid
Molecular weight:
861.93
Ref: TM-T8488
| 1mg | 95.00 € | ||
| 5mg | 196.00 € | ||
| 10mg | 343.00 € | ||
| 25mg | 580.00 € | ||
| 50mg | 822.00 € | ||
| 100mg | 1,112.00 € | ||
| 500mg | 2,270.00 € | ||
| 1mL*10mM (DMSO) | 273.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
KW-2449
CAS:1000669-72-6
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora …
Formula:
C20H20N4O
Purity:
98.43% - 99.89%
Color and Shape:
Solid
Molecular weight:
332.4
Ref: TM-T2341
| 2mg | 39.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 143.00 € | ||
| 50mg | 255.00 € | ||
| 100mg | 472.00 € | ||
| 500mg | 1,056.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BGG463
CAS:890129-26-7
BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 …
Formula:
C30H29F3N6O3
Purity:
100% - 95.05%
Color and Shape:
Solid
Molecular weight:
578.58
Ref: TM-T4618
| 1mg | 61.00 € | ||
| 2mg | 85.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 345.00 € | ||
| 50mg | 494.00 € | ||
| 100mg | 716.00 € | ||
| 1mL*10mM (DMSO) | 153.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Asciminib
CAS:1492952-76-7
Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5-0.8nM).
Formula:
C20H18ClF2N5O3
Purity:
97.93% - 99.45%
Color and Shape:
Solid
Molecular weight:
449.84
Ref: TM-T5177
| 1mg | 62.00 € | ||
| 2mg | 90.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 300.00 € | ||
| 50mg | 418.00 € | ||
| 100mg | 618.00 € | ||
| 500mg | 1,291.00 € | ||
| 1mL*10mM (DMSO) | 139.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Imatinib
CAS:152459-95-5
Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities …
Formula:
C29H31N7O
Purity:
100% - 99.94%
Color and Shape:
Off White Powder
Molecular weight:
493.6
Ref: TM-T6230
| 1g | 115.00 € | ||
| 5g | 196.00 € | ||
| 100mg | 42.00 € | ||
| 200mg | 56.00 € | ||
| 500mg | 85.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
