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Caspase

Caspase

Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.

Found 125 products of "Caspase"

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  • p-nitro-Pifithrin-α
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    p-nitro-Pifithrin-α

    CAS:
    <p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>
    Formula:C15H16BrN3O3S
    Color and Shape:Solid
    Molecular weight:398.27

    Ref: TM-T21978

  • SDZ 224-015
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    SDZ 224-015

    CAS:
    <p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>
    Formula:C30H35Cl2N3O9
    Purity:95.49% - 95.49%
    Color and Shape:Solid
    Molecular weight:652.52

    Ref: TM-T36534

  • VRT-043198
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    VRT-043198

    CAS:
    <p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>
    Formula:C22H29ClN4O6
    Color and Shape:Solid
    Molecular weight:480.94

    Ref: TM-T69632

  • QM31
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    QM31

    CAS:
    <p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>
    Formula:C39H38Cl4N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:768.56

    Ref: TM-T12599

  • N1,N11-Diethylnorspermine
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    N1,N11-Diethylnorspermine

    CAS:
    <p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT &amp; H2O2.</p>
    Formula:C13H32N4
    Color and Shape:Solid
    Molecular weight:244.42

    Ref: TM-T60348

  • GRI977143
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    GRI977143

    CAS:
    <p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>
    Formula:C22H17NO4S
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:391.44

    Ref: TM-T22812

  • OT-82
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    OT-82

    CAS:
    <p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>
    Formula:C26H21FN4O
    Purity:98.91% - 99.315%
    Color and Shape:Solid
    Molecular weight:424.47

    Ref: TM-T12330

  • ML132
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    ML132

    CAS:
    <p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>
    Formula:C22H28ClN5O5
    Color and Shape:Solid
    Molecular weight:477.94

    Ref: TM-T16105

  • CZL55
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    CZL55

    CAS:
    <p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>
    Formula:C20H22N2O6
    Purity:98.19%
    Color and Shape:Solid
    Molecular weight:386.4

    Ref: TM-T73556

  • NLRP3 agonist 1
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    NLRP3 agonist 1

    CAS:
    <p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>
    Formula:C15H16N6
    Purity:99.01%
    Color and Shape:Solid
    Molecular weight:280.33

    Ref: TM-T81668

  • M190S
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    M190S

    CAS:
    <p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>
    Formula:C21H21N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T79747

  • Ac-YVAD-pNA
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    Ac-YVAD-pNA

    CAS:
    <p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>
    Formula:C29H36N6O10
    Color and Shape:Solid
    Molecular weight:628.639

    Ref: TM-T84839

  • GDC-2394
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    GDC-2394

    CAS:
    <p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>
    Formula:C20H25N5O4S
    Color and Shape:Solid
    Molecular weight:431.51

    Ref: TM-T69745

  • CIL62
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    CIL62

    CAS:
    <p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>
    Formula:C23H26O5
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:382.45

    Ref: TM-T8468

  • EP1013
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    EP1013

    CAS:
    <p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>
    Formula:C18H23FN2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:382.38

    Ref: TM-T11210

  • M867
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    M867

    CAS:
    <p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>
    Formula:C27H43N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:561.67

    Ref: TM-T79498

  • Ac-VAD-CHO
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    Ac-VAD-CHO

    CAS:
    <p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>
    Formula:C14H23N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:329.35

    Ref: TM-T80624

  • Z-YVAD-CMK
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    Z-YVAD-CMK

    CAS:
    <p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>
    Formula:C30H37ClN4O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:633.09

    Ref: TM-T80659

  • ZIF-8
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    ZIF-8

    CAS:
    <p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>
    Formula:C4H6N2Zn
    Color and Shape:Solid
    Molecular weight:147.513

    Ref: TM-T205703

  • Caspase-3-IN-2
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    Caspase-3-IN-2

    CAS:
    <p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>
    Formula:C10H6ClNO5
    Color and Shape:Solid
    Molecular weight:255.611

    Ref: TM-T205720

  • CymitQuimica logo
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    N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride

    CAS:
    <p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>
    Formula:C14H22Cl2N2O3S
    Molecular weight:369.31

    Ref: TM-T210015

  • CymitQuimica logo
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    M826

    <p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7

    Ref: TM-T79497

  • Ac-DMLD-CMK
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    Ac-DMLD-CMK

    CAS:
    <p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>
    Formula:C22H35ClN4O9S
    Color and Shape:Solid
    Molecular weight:567.053

    Ref: TM-TP3236

  • (2R,3S)-Emricasan
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    (2R,3S)-Emricasan

    CAS:
    <p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>
    Formula:C26H27F4N3O7
    Color and Shape:Solid
    Molecular weight:569.5

    Ref: TM-T89856

  • Z-VA-DL-D-FMK
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    Z-VA-DL-D-FMK

    CAS:
    <p>Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.</p>
    Formula:C21H28FN3O7
    Color and Shape:Solid
    Molecular weight:453.46

    Ref: TM-T88570