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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3493 products of "Cell Cycle/Checkpoint"

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  • RNA polymerase II-IN-1

    CAS:
    <p>RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.</p>
    Formula:C38H53N11O12S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:887.96
  • Bisindolylmaleimide X hydrochloride

    CAS:
    <p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>
    Formula:C26H25ClN4O2
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:460.96
  • Antifolate C1

    CAS:
    <p>Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.</p>
    Formula:C19H21N5O6S
    Color and Shape:Solid
    Molecular weight:447.46
  • α7β1 integrin modulator-1

    CAS:
    <p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>
    Formula:C23H29N3O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:475.56
  • AR-13503

    CAS:
    <p>AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.</p>
    Formula:C19H19N3O2
    Color and Shape:Solid
    Molecular weight:321.37
  • OXA-06 hydrochloride

    CAS:
    <p>OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].</p>
    Formula:C21H20Cl2FN3
    Color and Shape:Solid
    Molecular weight:404.31
  • Votoplam

    CAS:
    <p>Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].</p>
    Formula:C21H25N9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:419.48
  • Luvixasertib hydrochloride

    CAS:
    <p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>
    Formula:C28H31ClN6O3
    Color and Shape:Solid
    Molecular weight:535.04
  • CDK9-IN-9

    CAS:
    <p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>
    Formula:C22H23F2N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.51
  • SB-743921 free base

    CAS:
    <p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>
    Formula:C31H33ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.06
  • BVDU 5′-Triphosphate

    CAS:
    <p>BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.</p>
    Formula:C11H16BrN2O14P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:573.08
  • ASC-69

    CAS:
    <p>ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].</p>
    Formula:C19H19N7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:345.4
  • m-Se3

    CAS:
    <p>m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].</p>
    Formula:C29H23IN2Se
    Purity:98%
    Color and Shape:Solid
    Molecular weight:605.37
  • JNJ-26076713

    CAS:
    <p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>
    Formula:C29H38N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.64
  • PLK1-IN-4

    CAS:
    <p>PLK1-IN-4: strong PLK1 blocker (&lt;0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>
    Formula:C24H25F3N6O4S
    Color and Shape:Solid
    Molecular weight:550.55
  • 5-DACTHF

    CAS:
    <p>5,11-methenyltetrahydrohomofolate blocks GAR &amp; AIR transformylase; used as an anti-purine drug.</p>
    Formula:C19H24N6O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.43
  • αvβ6 integrin inhibitor 2

    CAS:
    <p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>
    Formula:C21H30N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:386.49
  • PVZB1194

    CAS:
    <p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>
    Formula:C13H9F4NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.28
  • DUB-IN-7

    CAS:
    <p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>
    Formula:C17H19N5O
    Color and Shape:Solid
    Molecular weight:309.37
  • Synstatin (92-119)

    CAS:
    <p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>
    Formula:C133H207N35O46
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3032.27