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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3482 products of "Cell Cycle/Checkpoint"

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  • 2′-OMe-GDP

    CAS:
    <p>2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.</p>
    Formula:C11H17N5O11P2
    Color and Shape:Solid
    Molecular weight:457.23
  • ddCTP trisodium


    <p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>
    Formula:C9H13N3Na3O12P3
    Color and Shape:Solid
    Molecular weight:517.1
  • CDK1-IN-5


    <p>CDK1-IN-5 is a selective inhibitor for CDK1 (IC50: 42.19 nM), CDK2, CDK5, halting cancer cell growth.</p>
    Formula:C27H26ClN5OS
    Color and Shape:Solid
    Molecular weight:504.05
  • CDK9-IN-11

    CAS:
    <p>CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].</p>
    Formula:C20H25N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:371.43
  • CHK1-IN-4

    CAS:
    <p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>
    Formula:C18H18BrN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.29
  • TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Formula:C18H16ClN5
    Color and Shape:Solid
    Molecular weight:337.81
  • Ladirubicin

    CAS:
    <p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>
    Formula:C29H31NO11S
    Color and Shape:Solid
    Molecular weight:601.62
  • 2'-(2-Nitrobenzyl)-ATP

    CAS:
    <p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>
    Formula:C17H21N6O15P3
    Color and Shape:Solid
    Molecular weight:642.30
  • c-Myc inhibitor 4


    <p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>
    Formula:C26H33FN6O3
    Color and Shape:Solid
    Molecular weight:496.58
  • TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898
  • CDK/HDAC-IN-1


    <p>CDK/HDAC-IN-1 inhibits CDK2/4/6 &amp; HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.</p>
    Formula:C20H18N4O4
    Color and Shape:Solid
    Molecular weight:378.38
  • GTSE1-IN-1

    CAS:
    <p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>
    Formula:C21H24FN7
    Color and Shape:Solid
    Molecular weight:393.46
  • PD-L1-IN-7

    CAS:
    <p>PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.</p>
    Formula:C46H50N6O7
    Color and Shape:Solid
    Molecular weight:798.93
  • SR121566A

    CAS:
    <p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>
    Formula:C20H25N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.51
  • CDK2-IN-8


    <p>CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.</p>
    Formula:C22H25N5O3
    Color and Shape:Solid
    Molecular weight:407.47
  • MU147

    CAS:
    <p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>
    Formula:C19H13N3O3S
    Color and Shape:Solid
    Molecular weight:363.39
  • Dyrk1A-IN-1


    <p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>
    Formula:C23H20N4O3S
    Color and Shape:Solid
    Molecular weight:432.49
  • SCH-1473759

    CAS:
    <p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>
    Formula:C20H26N8OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.54
  • Cdc7-IN-11

    CAS:
    <p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>
    Formula:C20H22F2N4O2S
    Color and Shape:Solid
    Molecular weight:420.48
  • YKL-1-116

    CAS:
    <p>YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.</p>
    Formula:C34H38N8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:606.72