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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3482 products of "Cell Cycle/Checkpoint"

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  • CDK2-IN-40
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    CDK2-IN-40

    CAS:
    <p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>
    Formula:C16H21N7O2
    Color and Shape:Solid
    Molecular weight:343.384

    Ref: TM-T205452

  • CDK2-IN-39
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    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Formula:C14H15N3O4S
    Color and Shape:Solid
    Molecular weight:321.352

    Ref: TM-T204890

  • MKLP2-IN-1
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    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Formula:C23H19BrFN3O2
    Color and Shape:Solid
    Molecular weight:468.318

    Ref: TM-T205538

  • CLK1/2-IN-1
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    CLK1/2-IN-1

    CAS:
    <p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>
    Formula:C21H20F3N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:443.42

    Ref: TM-T23896

  • LN-439A
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    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Formula:C24H26FN3O4
    Color and Shape:Solid
    Molecular weight:439.48

    Ref: TM-T200435

  • p38α inhibitor 9
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    p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Formula:C27H24FN3O3
    Color and Shape:Solid
    Molecular weight:457.496

    Ref: TM-T206722

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    CDK8-IN-11 hydrochloride

    <p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>
    Formula:C19H16ClF3N4O2
    Color and Shape:Solid
    Molecular weight:424.8

    Ref: TM-T62293

  • USP7-IN-10
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    USP7-IN-10

    CAS:
    <p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>
    Formula:C26H29ClN4O3S
    Color and Shape:Solid
    Molecular weight:513.05

    Ref: TM-T73136

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Formula:C26H27Cl2N3O
    Color and Shape:Solid
    Molecular weight:468.42

    Ref: TM-T200443

  • FT709
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    FT709

    CAS:
    <p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>
    Formula:C23H22N4O7S
    Color and Shape:Solid
    Molecular weight:498.51

    Ref: TM-T63375

  • CymitQuimica logo
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    CDK1-IN-3

    <p>CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.</p>
    Formula:C28H25ClF3N5O2
    Color and Shape:Solid
    Molecular weight:555.98

    Ref: TM-T63933

  • DNA polymerase-IN-6
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    DNA polymerase-IN-6

    CAS:
    <p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>
    Formula:C26H28ClFN8O4
    Color and Shape:Solid
    Molecular weight:571.003

    Ref: TM-T204284

  • WRN inhibitor 13
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    WRN inhibitor 13

    CAS:
    <p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>
    Formula:C16H20N2O5S
    Color and Shape:Solid
    Molecular weight:352.405

    Ref: TM-T204389

  • L-I-OddU
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    L-I-OddU

    CAS:
    <p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>
    Formula:C8H9IN2O5
    Color and Shape:Solid
    Molecular weight:340.07

    Ref: TM-T61080

  • SF0166
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    SF0166

    CAS:
    <p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>
    Formula:C23H27F2N5O4
    Color and Shape:Solid
    Molecular weight:475.49

    Ref: TM-T70368

  • LIMK1 inhibitor 1
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    LIMK1 inhibitor 1

    CAS:
    <p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>
    Formula:C12H15N3S2
    Color and Shape:Solid
    Molecular weight:265.398

    Ref: TM-T204784

  • GR 83895
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    GR 83895

    CAS:
    <p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>
    Formula:C29H39N9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.74

    Ref: TM-T25460

  • PD-1-IN-17
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    PD-1-IN-17

    CAS:
    <p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>
    Formula:C13H22N6O7
    Purity:99.6%
    Color and Shape:Solid
    Molecular weight:374.35

    Ref: TM-T12377

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    DNA Gyrase-IN-1

    <p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>
    Formula:C24H24FN7O6
    Color and Shape:Solid
    Molecular weight:525.49

    Ref: TM-T63681

  • KL-50
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    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Formula:C7H7FN6O2
    Color and Shape:Solid
    Molecular weight:226.17

    Ref: TM-T200136