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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3482 products of "Cell Cycle/Checkpoint"

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  • 8-Oxo-dATP

    CAS:
    <p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>
    Formula:C10H12Li4N5O13P3
    Color and Shape:Solid
    Molecular weight:530.913
  • CDK12/13 ligand 1

    CAS:
    <p>ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.</p>
    Formula:C26H26BrN5O
    Color and Shape:Solid
    Molecular weight:504.42
  • Sovesudil hydrochloride


    <p>Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.</p>
    Formula:C23H23ClFN3O3
    Color and Shape:Solid
    Molecular weight:443.9
  • Polθ-IN-6

    CAS:
    <p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>
    Formula:C25H23N3O3S
    Color and Shape:Solid
    Molecular weight:445.53
  • NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Formula:C18H13NO3
    Color and Shape:Solid
    Molecular weight:291.301
  • NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Formula:C28H24FN5O5
    Color and Shape:Solid
    Molecular weight:529.519
  • Dyrk1A/B-IN-1


    <p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>
    Formula:C21H17N3O2S2
    Color and Shape:Solid
    Molecular weight:407.51
  • WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Formula:C33H33ClF3N9O5
    Color and Shape:Solid
    Molecular weight:728.12
  • Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Formula:C11H15N5O3
    Color and Shape:Solid
    Molecular weight:265.27
  • D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Formula:C19H22N4O3
    Color and Shape:Solid
    Molecular weight:354.403
  • DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Formula:C15H21N3O3S
    Color and Shape:Solid
    Molecular weight:323.41
  • Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Formula:C22H16FN3O2S
    Color and Shape:Solid
    Molecular weight:405.445
  • BRD-7880

    CAS:
    <p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>
    Formula:C32H38N4O7
    Color and Shape:Solid
    Molecular weight:590.67
  • CDK2 degrader 4

    CAS:
    <p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>
    Formula:C23H26ClN3O5
    Color and Shape:Solid
    Molecular weight:459.923
  • RMS-07

    CAS:
    <p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>
    Formula:C35H40N8O2
    Color and Shape:Solid
    Molecular weight:604.74
  • GSK3335103

    CAS:
    <p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>
    Formula:C27H36FN3O4
    Color and Shape:Solid
    Molecular weight:485.59
  • CDK7/12-IN-1

    CAS:
    <p>CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.</p>
    Formula:C25H34N8O
    Color and Shape:Solid
    Molecular weight:462.59
  • Rhodblock 1a

    CAS:
    <p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>
    Formula:C20H16N2O2
    Color and Shape:Solid
    Molecular weight:316.353
  • LZ9

    CAS:
    <p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>
    Formula:C17H11F3N4O2
    Color and Shape:Solid
    Molecular weight:360.29
  • (R)-CSN5i-3

    CAS:
    <p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>
    Formula:C28H29F2N5O2
    Purity:99.76% - 99.97%
    Color and Shape:Solid
    Molecular weight:505.56