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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3482 products of "Cell Cycle/Checkpoint"

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  • 5-Iminodaunorubicin hydrochloride

    CAS:
    <p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>
    Formula:C27H31ClN2O9
    Color and Shape:Solid
    Molecular weight:563.00
  • Kolavenic acid analog

    CAS:
    <p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57
  • MtTMPK-IN-7


    <p>MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.</p>
    Formula:C27H29ClN6O3
    Color and Shape:Solid
    Molecular weight:521.01
  • CDK2/4-IN-2

    CAS:
    <p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>
    Formula:C18H20F3N7O3S2
    Color and Shape:Solid
    Molecular weight:503.52
  • MtTMPK-IN-9


    <p>MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.</p>
    Formula:C25H26N6O7
    Color and Shape:Solid
    Molecular weight:522.51
  • Epolactaene

    CAS:
    <p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases &amp; human DNA topoisomerase II.</p>
    Formula:C21H27NO6
    Color and Shape:Solid
    Molecular weight:389.44
  • DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Formula:C13H8FN3O3
    Color and Shape:Solid
    Molecular weight:273.219
  • Anticancer agent 30


    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81
  • 4,5'-Dimethylangelicin-NHS


    <p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity &amp; photosensitivity.</p>
    Formula:C21H19NO7S
    Color and Shape:Solid
    Molecular weight:429.44
  • DYRKs-IN-1 hydrochloride

    CAS:
    <p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) &amp; DYRK1B (8 nM IC50) with antitumor properties.</p>
    Formula:C30H31Cl2N7O4
    Color and Shape:Solid
    Molecular weight:624.52
  • LNA-GTP

    CAS:
    <p>LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.</p>
    Formula:C11H16N5O14P3
    Color and Shape:Solid
    Molecular weight:535.19
  • DNA gyrase B-IN-1


    <p>DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.</p>
    Formula:C23H18ClF3N6O4S
    Color and Shape:Solid
    Molecular weight:566.94
  • Zalunfiban dihydrochloride


    <p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>
    Formula:C16H20Cl2N8O2S
    Color and Shape:Solid
    Molecular weight:459.35
  • α5β1 integrin agonist-1

    CAS:
    <p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>
    Formula:C24H26FN5O9
    Color and Shape:Solid
    Molecular weight:547.49
  • (R)-Atuveciclib

    CAS:
    <p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>
    Formula:C18H18FN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.43
  • FT3967385


    <p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>
    Formula:C21H19N5O2
    Color and Shape:Solid
    Molecular weight:373.41
  • WRN inhibitor 11

    CAS:
    <p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>
    Formula:C34H35ClF3N9O5
    Color and Shape:Solid
    Molecular weight:742.15
  • AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Formula:C19H19N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.37
  • RAD51-IN-7

    CAS:
    <p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>
    Formula:C25H31N5O4S2
    Color and Shape:Solid
    Molecular weight:529.67
  • LY 254155

    CAS:
    <p>LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.</p>
    Formula:C19H23N5O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:449.48