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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3480 products of "Cell Cycle/Checkpoint"

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  • Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Formula:C11H15N5O3
    Color and Shape:Solid
    Molecular weight:265.27
  • Antiangiogenic agent 2


    <p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>
    Formula:C26H26FN3O4
    Color and Shape:Solid
    Molecular weight:463.5
  • D-G23

    CAS:
    <p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>
    Formula:C19H22N4O3
    Color and Shape:Solid
    Molecular weight:354.403
  • 2'-F-CDP

    CAS:
    <p>2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.</p>
    Formula:C9H14FN3O10P2
    Color and Shape:Solid
    Molecular weight:405.17
  • Cdc7-IN-11

    CAS:
    <p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>
    Formula:C20H22F2N4O2S
    Color and Shape:Solid
    Molecular weight:420.48
  • Dmf-dg

    CAS:
    <p>Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.</p>
    Formula:C13H18N6O4
    Color and Shape:Solid
    Molecular weight:322.32
  • Rhodblock 1a

    CAS:
    <p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>
    Formula:C20H16N2O2
    Color and Shape:Solid
    Molecular weight:316.353
  • Hesperadin hydrochloride


    <p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>
    Formula:C29H33ClN4O3S
    Color and Shape:Solid
    Molecular weight:553.12
  • CYP2C19-IN-1


    <p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>
    Formula:C26H26N2O6S
    Color and Shape:Solid
    Molecular weight:494.56
  • CDK9-IN-38

    CAS:
    <p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>
    Formula:C22H23N5O3S
    Color and Shape:Solid
    Molecular weight:437.515
  • Chk1-IN-5

    CAS:
    <p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>
    Formula:C18H18FN7O2
    Color and Shape:Solid
    Molecular weight:383.38
  • N-Isobutyryl-2', 3'-acetyl-guanosine

    CAS:
    <p>N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.</p>
    Formula:C18H23N5O8
    Color and Shape:Solid
    Molecular weight:437.404
  • Epolactaene

    CAS:
    <p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases &amp; human DNA topoisomerase II.</p>
    Formula:C21H27NO6
    Color and Shape:Solid
    Molecular weight:389.44
  • DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Formula:C15H21N3O3S
    Color and Shape:Solid
    Molecular weight:323.41
  • 8-Oxo-dATP

    CAS:
    <p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>
    Formula:C10H12Li4N5O13P3
    Color and Shape:Solid
    Molecular weight:530.913
  • UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Formula:C15H22N4O5S
    Color and Shape:Solid
    Molecular weight:370.424
  • 5-Methylcytosine hydrochloride

    CAS:
    <p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>
    Formula:C5H8ClN3O
    Color and Shape:Solid
    Molecular weight:161.59
  • 2-CEES

    CAS:
    <p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>
    Formula:C4H9ClS
    Color and Shape:Solid
    Molecular weight:124.632
  • 2'-O-MOE-GMP

    CAS:
    <p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>
    Formula:C13H20N5O9P
    Color and Shape:Solid
    Molecular weight:421.30
  • CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Formula:C23H19ClN4O3
    Color and Shape:Solid
    Molecular weight:434.88