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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3477 products of "Cell Cycle/Checkpoint"

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  • BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Formula:C27H32N8O
    Color and Shape:Solid
    Molecular weight:484.596
  • Aurora inhibitor 1

    CAS:
    <p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>
    Formula:C23H25N9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.57
  • FR-β ligand 1

    CAS:
    <p>FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.</p>
    Formula:C22H25N5O6
    Color and Shape:Solid
    Molecular weight:455.46
  • DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.319
  • MY05

    CAS:
    <p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>
    Formula:C19H11ClN4O
    Color and Shape:Solid
    Molecular weight:346.77
  • Anticancer agent 30


    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81
  • TA-316

    CAS:
    <p>Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.</p>
    Formula:C28H25BrN4O5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:641.56
  • CDK4-IN-1

    CAS:
    <p>CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50&gt;15 uM) and CDK2/Cyclin A (IC50</p>
    Formula:C22H29ClN8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:440.97
  • SGC-CLK-1

    CAS:
    <p>SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.</p>
    Formula:C19H15F3N6O2
    Color and Shape:Solid
    Molecular weight:416.36
  • MTH1 activator-1

    CAS:
    <p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>
    Formula:C29H23F3N4O2
    Color and Shape:Solid
    Molecular weight:516.514
  • GFB-12811

    CAS:
    <p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>
    Formula:C22H23F4N5O
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:449.44
  • HRO761

    CAS:
    <p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>
    Formula:C31H31ClF3N9O5
    Purity:98.74% - 99.62%
    Color and Shape:Solid
    Molecular weight:702.08
  • Elacytarabine

    CAS:
    <p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>
    Formula:C27H45N3O6
    Purity:97.69%
    Color and Shape:Solid
    Molecular weight:507.66
  • CTPS1-IN-1

    CAS:
    <p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>
    Formula:C21H22N6O4S2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:486.57
  • LY3143921 hydrate

    CAS:
    <p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>
    Formula:C16H14FN5O2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:327.31
  • SR 11302

    CAS:
    <p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>
    Formula:C26H32O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:376.53
  • INCB086550

    CAS:
    <p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 &lt;= 10 nM.</p>
    Formula:C41H39N7O4
    Purity:98.49%
    Color and Shape:Solid
    Molecular weight:693.79
  • Troxacitabine

    CAS:
    <p>Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.</p>
    Formula:C8H11N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:213.19

    Ref: TM-T17175

    1mg
    Discontinued
    Discontinued product
  • Bicyclomycin benzoate

    CAS:
    <p>Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.</p>
    Formula:C19H22N2O8
    Color and Shape:Solid
    Molecular weight:406.39

    Ref: TM-T10541

    1mg
    Discontinued
    Discontinued product
  • Tanuxiciclib

    CAS:
    <p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>
    Formula:C15H13FN6O
    Color and Shape:Solid
    Molecular weight:312.308

    Ref: TM-T39404

    ne
    Discontinued
    Discontinued product