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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3485 products of "Cell Cycle/Checkpoint"

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  • Mps1-IN-6


    <p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>
    Formula:C35H39N9O3
    Color and Shape:Solid
    Molecular weight:633.74
  • 5-Methylcytidine 5′-triphosphate

    CAS:
    <p>5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate</p>
    Formula:C10H18N3O14P3
    Color and Shape:Solid
    Molecular weight:497.18
  • PDI-IN-4


    <p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>
    Formula:C17H12F3NO2
    Color and Shape:Solid
    Molecular weight:319.278
  • CDK4/6-IN-23


    <p>CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.</p>
    Formula:C32H34FN7O4
    Color and Shape:Solid
    Molecular weight:599.655
  • Anti-MRSA agent 7


    <p>Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.</p>
    Formula:C22H20BrF2N3O4
    Color and Shape:Solid
    Molecular weight:508.31
  • HSDVHK-NH2

    CAS:
    <p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>
    Formula:C30H48N12O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:720.78
  • Censavudine

    CAS:
    <p>Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.</p>
    Formula:C12H12N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:248.23
  • Filanesib TFA

    CAS:
    <p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>
    Formula:C22H23F5N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:534.5
  • dCeMM3 

    CAS:
    <p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>
    Formula:C14H11ClN4OS
    Purity:98.48% - 99.41%
    Color and Shape:Solid
    Molecular weight:318.78
  • α2β1 Integrin Ligand Peptide

    CAS:
    <p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>
    Formula:C14H22N4O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:390.35
  • 5'-O-DMT-N4-Bz-2'-F-dC

    CAS:
    <p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>
    Formula:C37H34FN3O7
    Color and Shape:Solid
    Molecular weight:651.68
  • RNA polymerase II-IN-2


    <p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>
    Formula:C41H58N10O12S
    Color and Shape:Solid
    Molecular weight:915.02
  • Fuzapladib

    CAS:
    <p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>
    Formula:C15H20F3N3O3S
    Purity:99.87%
    Color and Shape:Soild
    Molecular weight:379.4
  • Adenosine Dialdehyde (ADOX)

    CAS:
    <p>Adenosine Dialdehyde, a purine analogue, inhibits SAHH (Ki=3.3 nM), and shows strong anti-tumor effects in vivo.</p>
    Formula:C10H11N5O4
    Purity:95%
    Color and Shape:Solid
    Molecular weight:265.23
  • GK13S


    <p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>
    Formula:C21H22N6O2
    Color and Shape:Solid
    Molecular weight:390.44
  • UnyLinker 12 TEA


    <p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>
    Formula:C39H35NO10C6H15N
    Color and Shape:Solid
    Molecular weight:778.34655
  • CDK7-IN-5

    CAS:
    <p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>
    Formula:C34H45N9O2
    Color and Shape:Solid
    Molecular weight:611.795
  • DHFR-IN-11


    <p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>
    Color and Shape:Odour Solid
  • PD-1/PD-L1-IN-52


    <p>PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.</p>
    Color and Shape:Odour Solid
  • Mumefural

    CAS:
    <p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>
    Formula:C12H12O9
    Color and Shape:Solid
    Molecular weight:300.22