
Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(94 products)
- CDK(500 products)
- Cell Cycle Arrest(4 products)
- Chk(42 products)
- DYRK(48 products)
- Dynamin(23 products)
- Ferroptosis(215 products)
- HSP(169 products)
- Integrin(224 products)
- Kinesin(66 products)
- LIM Kinase(19 products)
- Microtubule Associated(261 products)
- PKC(102 products)
- PLK(28 products)
- ROCK(69 products)
- Rho(2 products)
- Wee1(15 products)
- c-Myc(69 products)
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Found 3480 products of "Cell Cycle/Checkpoint"
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Antiviral agent 67
CAS:<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.374Dyrk1A/B-IN-1
<p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>Formula:C21H17N3O2S2Color and Shape:SolidMolecular weight:407.51CD 10899
CAS:<p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>Formula:C34H50N8O4Color and Shape:SolidMolecular weight:634.81iPAF1C
CAS:<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formula:C27H26BrFN4OColor and Shape:SolidMolecular weight:521.42Mps1-IN-8
CAS:<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Formula:C35H47N8O6PColor and Shape:SolidMolecular weight:706.77LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formula:C28H27N5O2Color and Shape:SolidMolecular weight:465.555'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
CAS:<p>5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.</p>Formula:C36H39N5O8Color and Shape:SolidMolecular weight:669.724BRD-7880
CAS:<p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>Formula:C32H38N4O7Color and Shape:SolidMolecular weight:590.67CDK8-IN-11 hydrochloride
<p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>Formula:C19H16ClF3N4O2Color and Shape:SolidMolecular weight:424.8(R)-CSN5i-3
CAS:<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formula:C28H29F2N5O2Purity:99.76% - 99.97%Color and Shape:SolidMolecular weight:505.56PLK1-IN-11
CAS:<p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>Formula:C12H11N5OColor and Shape:SolidMolecular weight:241.249CDK2-IN-8
<p>CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.</p>Formula:C22H25N5O3Color and Shape:SolidMolecular weight:407.47Bersiporocin
CAS:<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formula:C15H19Cl2N3OPurity:98.88% - 99.79%Color and Shape:SolidMolecular weight:328.24CDK9-IN-13
<p>CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.</p>Formula:C27H35N5O2Color and Shape:SolidMolecular weight:461.6Haspin-IN-1
<p>Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.</p>Formula:C12H8N4O2SColor and Shape:SolidMolecular weight:272.28AR-13324 M1 metabolite
CAS:<p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>Formula:C19H19N3O2Purity:98%Color and Shape:SolidMolecular weight:321.37Anticancer agent 30
<p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>Formula:C22H15ClFNOColor and Shape:SolidMolecular weight:363.81SCH-1473759
CAS:<p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54Polθ-IN-8
CAS:<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Formula:C22H22ClN7O3SColor and Shape:SolidMolecular weight:499.97CDK/HDAC-IN-1
<p>CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.</p>Formula:C20H18N4O4Color and Shape:SolidMolecular weight:378.38IRE1α kinase-IN-4
CAS:<p>IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].</p>Formula:C29H31N7O2Color and Shape:SolidMolecular weight:509.6WRN inhibitor 11
CAS:<p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>Formula:C34H35ClF3N9O5Color and Shape:SolidMolecular weight:742.15c-Myc inhibitor 4
<p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>Formula:C26H33FN6O3Color and Shape:SolidMolecular weight:496.58Antibacterial agent 110
<p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>Formula:C22H21N5O4SColor and Shape:SolidMolecular weight:451.52'-(2-Nitrobenzyl)-ATP
CAS:<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Formula:C17H21N6O15P3Color and Shape:SolidMolecular weight:642.30Ladirubicin
CAS:<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Formula:C29H31NO11SColor and Shape:SolidMolecular weight:601.62MtTMPK-IN-1
<p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>Formula:C22H24N4O3Color and Shape:SolidMolecular weight:392.45Dyrk1A-IN-1
<p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>Formula:C23H20N4O3SColor and Shape:SolidMolecular weight:432.49GR 122222X
CAS:<p>GR 122222X is an inhibitor of topoisomerase II.</p>Formula:C26H35N5O11SPurity:98%Color and Shape:SolidMolecular weight:625.65(E)-Antiviral agent 67
CAS:<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.374L 734217
CAS:<p>L 734217 is an antagonist of the fibrinogen receptor.</p>Formula:C18H31N3O4Purity:98%Color and Shape:SolidMolecular weight:353.46CDK9-IN-11
CAS:<p>CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].</p>Formula:C20H25N3O4Purity:98%Color and Shape:SolidMolecular weight:371.4311-Oxahomoaminopterin
CAS:<p>11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.</p>Formula:C20H21N7O6Purity:98%Color and Shape:SolidMolecular weight:455.42Dyrk1A/α-synuclein-IN-1
<p>Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).</p>Formula:C20H21N5O3SColor and Shape:SolidMolecular weight:411.48OSI-7904L free acid
CAS:<p>OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.</p>Formula:C27H24N4O6Purity:98%Color and Shape:SolidMolecular weight:500.5CDK7-IN-33
CAS:<p>CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.</p>Formula:C29H36N6O4SColor and Shape:SolidMolecular weight:564.699Adafosbuvir
CAS:<p>Adafosbuvir has antiviral activity.</p>Formula:C22H29FN3O10PColor and Shape:SolidMolecular weight:545.457CDK8-IN-5
CAS:<p>CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.</p>Formula:C26H22N2O4Color and Shape:SolidMolecular weight:426.46PROTAC CDK12/13 Degrader-1
<p>PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.</p>Color and Shape:SolidMtTMPK-IN-3
CAS:<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Formula:C23H23Cl2N3O3Color and Shape:SolidMolecular weight:460.35USP7-IN-10
CAS:<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Formula:C26H29ClN4O3SColor and Shape:SolidMolecular weight:513.05DIDS
CAS:<p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>Formula:C16H10N2O6S4Purity:98%Color and Shape:SolidMolecular weight:454.52SGC-CLK-1
CAS:<p>SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.</p>Formula:C19H15F3N6O2Color and Shape:SolidMolecular weight:416.36Xanthosine-5'-Triphosphate trisodium
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formula:C10H12N4Na3O15P3Color and Shape:SolidMolecular weight:590.111CLK1/2-IN-1
CAS:<p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>Formula:C21H20F3N7OPurity:98%Color and Shape:SolidMolecular weight:443.42LIMK1 inhibitor 2
CAS:<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Formula:C10H11N3OSColor and Shape:SolidMolecular weight:221.2795-Fluorouridine 5'-phosphate
CAS:<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formula:C9H12FN2O9PColor and Shape:SolidMolecular weight:342.172Cimpuciclib tosylate
CAS:<p>Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.</p>Formula:C37H43FN8O4SColor and Shape:SolidMolecular weight:714.852'-Deoxycytidine hydrate
CAS:<p>2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.</p>Formula:C9H15N3O5Color and Shape:SolidMolecular weight:245.23Dencatistat
CAS:<p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>Formula:C24H27N7O5SPurity:98.85%Color and Shape:SolidMolecular weight:525.58CLK1/4-IN-1
<p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>Formula:C18H14ClNO4SColor and Shape:SolidMolecular weight:375.83Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formula:C34H35N3O10Color and Shape:SolidMolecular weight:645.662′-OMe-ADP
CAS:<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Formula:C11H17N5O10P2Color and Shape:SolidMolecular weight:441.23Elacytarabine
CAS:<p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>Formula:C27H45N3O6Purity:97.69%Color and Shape:SolidMolecular weight:507.66HRO761
CAS:<p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>Formula:C31H31ClF3N9O5Purity:98.74% - 99.62%Color and Shape:SolidMolecular weight:702.08CTPS1-IN-1
CAS:<p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>Formula:C21H22N6O4S2Purity:99.46%Color and Shape:SolidMolecular weight:486.57GFB-12811
CAS:<p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>Formula:C22H23F4N5OPurity:98.88%Color and Shape:SolidMolecular weight:449.44SR 11302
CAS:<p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>Formula:C26H32O2Purity:98.65%Color and Shape:SolidMolecular weight:376.53LY3143921 hydrate
CAS:<p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>Formula:C16H14FN5O2Purity:98.43%Color and Shape:SolidMolecular weight:327.31INCB086550
CAS:<p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.</p>Formula:C41H39N7O4Purity:98.49%Color and Shape:SolidMolecular weight:693.79Troxacitabine
CAS:<p>Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.</p>Formula:C8H11N3O4Purity:98%Color and Shape:SolidMolecular weight:213.19Bicyclomycin benzoate
CAS:<p>Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.</p>Formula:C19H22N2O8Color and Shape:SolidMolecular weight:406.39Formycin A
CAS:<p>Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.</p>Formula:C10H13N5O4Purity:98%Color and Shape:SolidMolecular weight:267.245'-O-DMT-N6-ibu-dA
CAS:<p>5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.</p>Formula:C35H37N5O6Color and Shape:SolidMolecular weight:623.71PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formula:C28H37N9O3Color and Shape:SolidMolecular weight:547.65NSC639828
CAS:<p>NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.</p>Formula:C18H13BrClN5O3Color and Shape:SolidMolecular weight:462.69Ethynylcytidine
CAS:<p>Ethynylcytidine is a nucleoside antimetabolite.</p>Formula:C11H13N3O5Purity:98%Color and Shape:SolidMolecular weight:267.245'-O-TBDMS-dT
CAS:<p>5’-O-TBDMS-dT is a nucleoside with protective and modification effects.</p>Formula:C16H28N2O5SiColor and Shape:SolidMolecular weight:356.49Tanuxiciclib
CAS:<p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>Formula:C15H13FN6OColor and Shape:SolidMolecular weight:312.3082'-Deoxy-2'-fluoro-5-iodouridine
CAS:<p>2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.</p>Formula:C9H10FIN2O5Color and Shape:SolidMolecular weight:372.095'-DMT-3'-TBDMS-ibu-rG
CAS:<p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>Formula:C41H51N5O8SiColor and Shape:SolidMolecular weight:769.96N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:<p>N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.</p>Formula:C38H35N5O6Color and Shape:SolidMolecular weight:657.727GSK-3/CDK5/CDK2-IN-1
CAS:<p>GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].</p>Formula:C21H22N4O2Color and Shape:SolidMolecular weight:362.433Deoxypseudouridine
CAS:<p>Deoxypseudouridine is a nucleotide analog.</p>Formula:C9H12N2O5Color and Shape:SolidMolecular weight:228.2Ref: TM-T13645
Discontinued productMitoE10
CAS:<p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>Formula:C42H55O5PSColor and Shape:SolidMolecular weight:702.92Ribocil-C
CAS:<p>Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.</p>Formula:C21H21N7OSPurity:98%Color and Shape:SolidMolecular weight:419.56-Amino-5-nitropyridin-2-one
CAS:<p>6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.</p>Formula:C5H5N3O3Purity:98%Color and Shape:SolidMolecular weight:155.11Tibremciclib
CAS:<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formula:C28H32F2N8Purity:98%Color and Shape:SolidMolecular weight:518.6PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formula:C19H19FN4O2SPurity:99.4%Color and Shape:SolidMolecular weight:386.44YK-2168
CAS:<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formula:C16H18ClN5Color and Shape:SolidMolecular weight:315.80Ref: TM-T200769
Discontinued product

