Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3477 products of "Cell Cycle/Checkpoint"

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N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.
Formula:C₄₁H₄₃N₃O₉
Color and Shape:Solid
Molecular weight:721.79
Ref: TM-T75224
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HSDVHK-NH2 TFA
HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [
Formula:C₃₂H₄₉F₃N₁₂O₁₁
Color and Shape:Solid
Molecular weight:834.8
Ref: TM-T75835
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5-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:
- 51549-36-1
5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.
Formula:C₂₂H₃₁N₃O₅Si
Color and Shape:Solid
Molecular weight:445.58
Ref: TM-T36972
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Erythromycin thiocyanate
CAS:
- 7704-67-8
Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.
Formula:C₃₈H₆₈N₂O₁₃S
Purity:98%
Color and Shape:Solid
Molecular weight:793.02
Ref: TM-T11233
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Integrin Binding Peptide
CAS:
- 278792-07-7
Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.
Formula:C₄₂H₆₃N₁₅O₁₆S
Color and Shape:Solid
Molecular weight:1066.12
Ref: TM-T40361
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m7GpppUmpG
CAS:
- 2638447-87-5
m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.
Formula:C₃₁H₄₂N₁₂O₂₆P₄
Color and Shape:Solid
Molecular weight:1122.63
Ref: TM-T74478
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2'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent
Formula:C₂₂H₄₃FN₇O₇P
Color and Shape:Solid
Molecular weight:567.59
Ref: TM-T75197
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LEB-03-146
CAS:
- 2858812-91-4
LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.
Formula:C₄₆H₅₇N₁₁O₈
Color and Shape:Solid
Molecular weight:892.01
Ref: TM-T74371
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O-Glycoprotease
O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.
Color and Shape:Odour Solid
Ref: TM-TRP-00267
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5'-O-DMT-N2-DMF-dG
CAS:
- 40094-22-2
5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.
Formula:C₃₄H₃₆N₆O₆
Color and Shape:Solid
Molecular weight:624.698
Ref: TM-T40500
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13-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.
Formula:C₁₂H₁₉F₂N₆O₁₂P₃
Color and Shape:Solid
Molecular weight:570.23
Ref: TM-T205409
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Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.
Formula:C₂₉H₄₂N₆O₉
Color and Shape:Odour Solid
Molecular weight:618.68
Ref: TM-TN9153
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Xylocytidine
CAS:
- 3530-56-1
Xylocytidine is a biochemical.
Formula:C₉H₁₃N₃O₅
Color and Shape:Solid
Molecular weight:243.22
Ref: TM-T35201
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GSK270822A
CAS:
- 864082-23-5
GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.
Formula:C₂₄H₂₀N₄O₂
Purity:98.64% - 99.78%
Color and Shape:Solid
Molecular weight:396.44
Ref: TM-T27467
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Endo-1,4-β-xylanase
CAS:
- 9025-57-4
Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.
Color and Shape:Solid
Ref: TM-T76179
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CDK12-IN-6
CAS:
- 2651196-71-1
CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).
Formula:C₂₀H₂₁F₂N₉
Color and Shape:Solid
Molecular weight:425.448
Ref: TM-T40289
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GSK299423
CAS:
- 1352149-24-6
GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.
Formula:C₂₅H₂₇N₅O₂S
Purity:97.34%
Color and Shape:Solid
Molecular weight:461.58
Ref: TM-T32008
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Biotin-PEG7-C2-S-Vidarabine
Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.
Formula:C₃₆H₆₀N₈O₁₂S₂
Color and Shape:Solid
Molecular weight:861.04
Ref: TM-T74385
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CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.
Formula:C₃₂H₃₄FN₇O₄
Color and Shape:Solid
Molecular weight:599.655
Ref: TM-T204550
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PP-C8
PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.
Formula:C₄₃H₅₁FN₁₂O₇
Color and Shape:Solid
Molecular weight:866.94
Ref: TM-T74359
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Guanosine triphosphate
CAS:
- 86-01-1
Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].
Formula:C₁₀H₁₆N₅O₁₄P₃
Color and Shape:Solid
Molecular weight:523.18
Ref: TM-T73596
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Ceftriaxone
CAS:
- 73384-59-5
Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.
Formula:C₁₈H₁₈N₈O₇S₃
Purity:96.08%
Color and Shape:Solid
Molecular weight:554.58
Ref: TM-T75295
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Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.
Color and Shape:Odour Solid
Ref: TM-T206879
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3'-Deoxy-GTP trisodium
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.
Color and Shape:Odour Solid
Ref: TM-T206808
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CDK9 inhibitor HH1
CAS:
- 204188-41-0
CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.
Formula:C₁₃H₁₅N₃OS
Purity:99.92%
Color and Shape:Solid
Molecular weight:261.34
Ref: TM-T118066
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Ficellomycin
CAS:
- 59458-27-4
Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.
Formula:C₁₃H₂₄N₆O₃
Color and Shape:Solid
Molecular weight:312.37
Ref: TM-T24063
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HSDVHK-NH2
CAS:
- 848644-86-0
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
Formula:C₃₀H₄₈N₁₂O₉
Purity:98%
Color and Shape:Solid
Molecular weight:720.78
Ref: TM-TP1879
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5'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.
Formula:C₄₄H₄₉F₂N₄O₇P
Color and Shape:Solid
Molecular weight:814.85
Ref: TM-T75190
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PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.
Formula:C₁₇H₁₂F₃NO₂
Color and Shape:Solid
Molecular weight:319.278
Ref: TM-T204195
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Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.
Formula:C₂₁H₂₅FN₄O₂
Color and Shape:Solid
Molecular weight:384.45
Ref: TM-T205260
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α2β1 Integrin Ligand Peptide
CAS:
- 134580-64-6
The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular
Formula:C₁₄H₂₂N₄O₉
Purity:98%
Color and Shape:Solid
Molecular weight:390.35
Ref: TM-TP1484
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5'-O-DMT-N4-Bz-2'-F-dC
CAS:
- 146954-77-0
5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.
Formula:C₃₇H₃₄FN₃O₇
Color and Shape:Solid
Molecular weight:651.68
Ref: TM-T37137
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RA-V
RA-V is a natural product that can be used as a reference standard.
Formula:C₁₆₀H₂₀₂N₂₄O₄₁
Color and Shape:Solid
Molecular weight:3117.5
Ref: TM-T124482
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N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.
Formula:C₁₅H₁₇N₃O₆
Color and Shape:Solid
Molecular weight:335.31
Ref: TM-T75237
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GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.
Formula:C₂₁H₂₂N₆O₂
Color and Shape:Solid
Molecular weight:390.44
Ref: TM-T75182
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UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.
Formula:C₃₉H₃₅NO₁₀C₆H₁₅N
Color and Shape:Solid
Molecular weight:778.34655
Ref: TM-TSW-00947
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Censavudine
CAS:
- 634907-30-5
Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.
Formula:C₁₂H₁₂N₂O₄
Purity:98%
Color and Shape:Solid
Molecular weight:248.23
Ref: TM-T30791
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CDK7-IN-5
CAS:
- 1817006-50-0
CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).
Formula:C₃₄H₄₅N₉O₂
Color and Shape:Solid
Molecular weight:611.795
Ref: TM-T39247
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PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.
Color and Shape:Odour Solid
Ref: TM-T200724
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CDK6/9-IN-1
CAS:
- 2414373-55-8
CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).
Formula:C₂₂H₂₅ClN₈O
Color and Shape:Solid
Molecular weight:452.95
Ref: TM-T40047
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N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.
Formula:C₁₄H₂₁N₅O₆
Color and Shape:Solid
Molecular weight:355.35
Ref: TM-T75060
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Ac-dA Phosphoramidite
CAS:
- 1027734-01-5
Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.
Formula:C₄₂H₅₀N₇O₇P
Color and Shape:Solid
Molecular weight:795.878
Ref: TM-T38425
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Fuzapladib
CAS:
- 141283-87-6
Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.
Formula:C₁₅H₂₀F₃N₃O₃S
Purity:99.87%
Color and Shape:Soild
Molecular weight:379.4
Ref: TM-T67749
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Filanesib TFA
CAS:
- 1781834-99-8
Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Formula:C₂₂H₂₃F₅N₄O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:534.5
Ref: TM-T25418
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Dihydro-5-azacytidine
CAS:
- 62488-57-7
Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
Formula:C₈H₁₄N₄O₅
Purity:>99.99%
Color and Shape:Solid
Molecular weight:246.22
Ref: TM-T40713
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Garenoxacin
CAS:
- 194804-75-6
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
Formula:C₂₃H₂₀F₂N₂O₄
Purity:98%
Color and Shape:Solid
Molecular weight:426.41
Ref: TM-T7179
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5'-O-DMT-ibu-dC
CAS:
- 100898-62-2
5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
Formula:C₃₄H₃₇N₃O₇
Color and Shape:Solid
Molecular weight:599.67
Ref: TM-T38405
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Carboxy-pyridostatin
CAS:
- 1417638-60-8
Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Formula:C₃₅H₃₄N₁₀O₇
Color and Shape:Solid
Molecular weight:706.71
Ref: TM-T30745
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CDK12-IN-2
CAS:
- 2244987-03-7
CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.
Formula:C₃₂H₃₂N₆O₂
Purity:99.31%
Color and Shape:Solid
Molecular weight:532.64
Ref: TM-T39752
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Py-MAA-Val-Cit-PAB-DX8951
CAS:
- 2504068-37-3
Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].
Formula:C₅₇H₆₆FN₁₁O₁₃S
Color and Shape:Solid
Molecular weight:1164.26
Ref: TM-T75117