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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3477 products of "Cell Cycle/Checkpoint"

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  • SNX7
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    SNX7

    CAS:
    <p>SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.</p>
    Formula:C15H14N2O
    Purity:99.05%
    Color and Shape:Solid
    Molecular weight:238.28

    Ref: TM-T77613

  • GS-443902 trisodium
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    GS-443902 trisodium

    CAS:
    <p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>
    Formula:C12H16N5O13P3·xNa
    Color and Shape:Solid

    Ref: TM-T38761

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    Catumaxomab

    CAS:
    <p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>
    Purity:95%
    Color and Shape:Liquid

    Ref: TM-T78307

  • Uridine triphosphate 13C9,15N2 sodium
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    Uridine triphosphate 13C9,15N2 sodium

    CAS:
    <p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>
    Formula:C9H1415N2NaO15P3
    Color and Shape:Solid
    Molecular weight:517.04

    Ref: TM-T36299

  • 11H-Benzo[a]carbazole
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    11H-Benzo[a]carbazole

    CAS:
    <p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>
    Formula:C16H11N
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:217.27

    Ref: TM-TN9686

  • Nogalamycin
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    Nogalamycin

    CAS:
    <p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>
    Formula:C39H49NO16
    Purity:98%
    Color and Shape:Solid
    Molecular weight:787.812

    Ref: TM-T28185

  • Erythromycin lactobionate
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    Erythromycin lactobionate

    CAS:
    <p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>
    Formula:C49H89NO25
    Color and Shape:Solid
    Molecular weight:1092.233

    Ref: TM-T37433

  • SMS 121
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    SMS 121

    CAS:
    <p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>
    Formula:C20H21NO5
    Purity:98.29%
    Color and Shape:Soild
    Molecular weight:355.38

    Ref: TM-T205876

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    CDK12/13-IN-2

    <p>CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.</p>
    Formula:C24H22FN7O2
    Color and Shape:Solid
    Molecular weight:459.48

    Ref: TM-T205272

  • JB300
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    JB300

    CAS:
    <p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>
    Formula:C43H45ClFN7O10S
    Color and Shape:Solid
    Molecular weight:906.375

    Ref: TM-T204223

  • TAS-119
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    TAS-119

    CAS:
    <p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>
    Formula:C23H22Cl2FN5O3
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:506.36

    Ref: TM-T34787

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    Farletuzumab

    CAS:
    <p>Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.</p>
    Purity:> 95%
    Color and Shape:Liquid
    Molecular weight:145.36 kDa

    Ref: TM-T76720

  • CTP Synthetase-IN-1 Ammonium salt
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    CTP Synthetase-IN-1 Ammonium salt

    <p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>
    Formula:C20H22F3N7O3S2
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:529.56

    Ref: TM-T72505L

  • pNP-ADPr
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    pNP-ADPr

    CAS:
    <p>pNP-ADPr: Used in PARG &amp; ARH3 activity assays; aids in PARP enzyme research.</p>
    Formula:C21H26N6O16P2
    Color and Shape:Solid
    Molecular weight:680.41

    Ref: TM-T41083

  • (1S,3R,5R)-PIM447 dihydrochloride
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    (1S,3R,5R)-PIM447 dihydrochloride

    <p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>
    Formula:C24H25Cl2F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:513.38

    Ref: TM-T13425

  • (E/Z)-THZ1 2HCl
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    (E/Z)-THZ1 2HCl

    CAS:
    <p>THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.</p>
    Formula:C31H30Cl3N7O2
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:638.98

    Ref: TM-T35332

  • Clofarabine-5'-diphosphate
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    Clofarabine-5'-diphosphate

    CAS:
    <p>Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>
    Formula:C10H13ClFN5O9P2
    Color and Shape:Solid
    Molecular weight:463.64

    Ref: TM-T203181

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    PD-1/PD-L1-IN-50

    <p>Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200687

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    DSPE-PEG2000-cRGD

    <p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>
    Color and Shape:Odour Solid

    Ref: TM-TCL-01138

  • Nusinersen
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    Nusinersen

    CAS:
    <p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>
    Purity:98.62%
    Color and Shape:Solid

    Ref: TM-T38656

  • 16,16-dimethyl Prostaglandin A1
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    16,16-dimethyl Prostaglandin A1

    CAS:
    <p>16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.</p>
    Formula:C22H36O4
    Color and Shape:Solid
    Molecular weight:364.526

    Ref: TM-T36040

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    Torvutatug

    CAS:
    <p>Torvutatug is a human IgG1κ monoclonal antibody that acts against FOLR1.</p>
    Color and Shape:Liquid

    Ref: TM-T9901A-894

  • N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
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    N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium

    CAS:
    <p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>
    Formula:C21H35N12O17P3
    Color and Shape:Solid
    Molecular weight:820.49

    Ref: TM-T74135

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    STX-100

    <p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>
    Purity:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-062

  • JH-XVI-178
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    JH-XVI-178

    CAS:
    <p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>
    Formula:C22H22ClN7O
    Color and Shape:Solid
    Molecular weight:435.92

    Ref: TM-T40280

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    DNA Gyrase-IN-12

    <p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200599

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    N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine

    <p>N3-(2S)-propyluridine is a uridine analog with potential as an antiepileptic and for antihypertensive agent research.</p>
    Formula:C22H35N3O10
    Color and Shape:Solid
    Molecular weight:501.53

    Ref: TM-T75233

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    Nocarnickelamides B

    <p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>
    Formula:C29H42N6O9
    Color and Shape:Odour Solid
    Molecular weight:618.68

    Ref: TM-TN9153

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    IRE1-IN-2

    <p>IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.</p>
    Formula:C16H20O6
    Color and Shape:Solid
    Molecular weight:308.12599

    Ref: TM-T207625

  • 5'-O-DMT-Bz-rC
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    5'-O-DMT-Bz-rC

    CAS:
    <p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>
    Formula:C37H35N3O8
    Color and Shape:Solid
    Molecular weight:649.69

    Ref: TM-T37135

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    Clofarabine-5'-diphosphate trisodium

    <p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>
    Formula:C10H10ClFN5Na3O9P2
    Color and Shape:Solid
    Molecular weight:529.58

    Ref: TM-T203582

  • 5'-O-TBDMS-dA
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    5'-O-TBDMS-dA

    CAS:
    <p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>
    Formula:C16H27N5O3Si
    Color and Shape:Solid
    Molecular weight:365.509

    Ref: TM-T37143

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    Anti-c-myc Antibody (9E10)

    <p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-960

  • Erythromycin thiocyanate
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    Erythromycin thiocyanate

    CAS:
    <p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>
    Formula:C38H68N2O13S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:793.02

    Ref: TM-T11233

  • Viquidacin
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    Viquidacin

    CAS:
    <p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>
    Formula:C25H29FN2O4S2
    Color and Shape:Solid
    Molecular weight:504.64

    Ref: TM-T35064

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    DSPE-PEG3000-iRGD

    <p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>
    Color and Shape:Odour Solid

    Ref: TM-TCL-01149

  • α-Methyl-DL-aspartic acid
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    α-Methyl-DL-aspartic acid

    CAS:
    <p>α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.</p>
    Formula:C5H9NO4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:147.13

    Ref: TM-T78044

  • Chk1-IN-6
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    Chk1-IN-6

    CAS:
    <p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>
    Formula:C16H18F3N7
    Color and Shape:Solid
    Molecular weight:365.364

    Ref: TM-T40091

  • αVβ8-IN-1
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    αVβ8-IN-1

    CAS:
    <p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>
    Formula:C25H32ClN5O4
    Color and Shape:Solid
    Molecular weight:502.01

    Ref: TM-T200044

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    TC113

    <p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>
    Formula:C37H50F2N12O13
    Color and Shape:Solid
    Molecular weight:908.86

    Ref: TM-T74400

  • (+)-Glaucarubinone
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    (+)-Glaucarubinone

    <p>(+)-Glaucarubinone is a natural product that can be used as a reference standard.</p>
    Formula:C25H34O10
    Color and Shape:Solid
    Molecular weight:494.537

    Ref: TM-T126136

  • EC0488
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    EC0488

    CAS:
    <p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>
    Formula:C65H98N16O34S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1679.63

    Ref: TM-T11144

  • WRN inhibitor 17
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    WRN inhibitor 17

    CAS:
    <p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>
    Formula:C33H34F4N4O6S
    Color and Shape:Solid
    Molecular weight:690.71

    Ref: TM-T203305

  • Dihydro-5-azacytidine
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    Dihydro-5-azacytidine

    CAS:
    <p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>
    Formula:C8H14N4O5
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:246.22

    Ref: TM-T40713

  • CDK4/6-IN-5
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    CDK4/6-IN-5

    CAS:
    <p>CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) &amp; 4.4 nM (CDK6/D3). (WO2019207463A1, A93)</p>
    Formula:C22H28ClFN6O4S
    Color and Shape:Solid
    Molecular weight:527.01

    Ref: TM-T39956

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    DHFR-IN-11

    <p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>
    Color and Shape:Odour Solid

    Ref: TM-T82570

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    DSPE-PEG2000-iRGD

    <p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>
    Color and Shape:Odour Solid

    Ref: TM-TCL-01137

  • Clofarabine-5'-triphosphate
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    Clofarabine-5'-triphosphate

    CAS:
    <p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>
    Formula:C10H14ClFN5O12P3
    Color and Shape:Solid
    Molecular weight:543.62

    Ref: TM-T203136

  • NUAK1-IN-1
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    NUAK1-IN-1

    <p>NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.</p>
    Formula:C25H30N6O
    Color and Shape:Solid
    Molecular weight:430.545

    Ref: TM-T205625

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    HDAC-IN-85

    <p>HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.</p>
    Formula:C24H27FN4O5
    Color and Shape:Solid
    Molecular weight:470.49

    Ref: TM-T205411